|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the contribution of the FAAH gene variation in polygenic obesity and type 2 diabetes mellitus (T2DM) in the French population, we investigated the entire FAAH locus.
|
20054193 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Human FAAH gene mutations are associated with increased body weight and obesity.
|
22442717 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It has been demonstrated that the polymorphism 385 C/A of fatty acid amide hydrolase was associated with obesity.
|
20102775 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest a role for the FAAH 385 A/A missense polymorphism as an endocannabinoid risk factor in overweight/obesity and may provide indirect evidence to support cannabinoid antagonist treatment strategies in overweight disorders.
|
15809662 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship of the polymorphism (cDNA 385 C->A) of FAAH gene and insulin resistance in obese patients with and without metabolic syndrome.
|
22609216 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We first report loss-of-function mutations in DGAT2 and FAAH in one obese subject, which may interact with each other to affect the adiposity penetrance, providing a model of genetic interaction associated with human obesity.
|
28243972 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This may explain the greater vulnerability for addiction and obesity in individuals with C385A genetic variant and by extension, suggest that a D3 antagonism strategy in substance use disorders should consider FAAH C385A polymorphism.
|
31775159 |
2020 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An association between Pro129Thr variant of the FAAH gene and obesity has been described, but various studies have yielded conflicting results.
|
18819056 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was designed to investigate the FAAH gene polymorphisms and to compare the obesity indices between different genotypes in Iranian overweight/obese women.
|
31286394 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the relationship of polymorphism (cDNA 385 C-->A) of FAAH gene on obesity parameters in patients with diabetes mellitus type 2.
|
20056290 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related dyslipidemia associated with FAAH, independent of insulin response, in multigenerational families of Northern European descent.
|
19958092 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The FAAH SNP rs324420 was associated with increased obesity (three studies).
|
30129173 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study confirms previously published significant over-representations of the FAAH 385 A allele in overweight/obese subjects and presents new data in BED patients that the 385 mutation is not significantly associated with BED-related obesity.
|
18295974 |
2008 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although analyses of these variants in 235 independent obesity families did not result in statistically significant effects (two-sided p-values between 0.14 and 0.75), the combined analysis of all 603 obesity families supported the idea of an association of two SNPs in FAAH (rs324420 and rs2295632) with early onset extreme obesity (p-values between 0.02 and 0.03).
|
20044928 |
2010 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The fatty acid amide hydrolase C385A (P129T) missense variant in cannabis users: studies of drug use and dependence in Caucasians.
|
17290447 |
2007 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Cannabis group ∗ FAAH genotype interaction predicted WM integrity in bilateral ATR (FA, right: p = .05 and left: p = .001) and fMinor (FA, p = .02).
|
26106535 |
2015 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
These findings are in accord with earlier reported associations between CNR1 and FAAH and CD intermediate phenotypes, and suggest that the underlying mechanism of these genetic effects may be enhanced neural response in reward areas of the brain in carriers of the CNR1 G allele and FAAH C/C genotype in response to marijuana cues.
|
20010552 |
2010 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We investigated a potential interaction between genetically inherited variation in fatty acid amide hydrolase (FAAH, C385A), which metabolizes the cannabis-like endocannabinoid anandamide, and dopaminergic system, measured by dopamine receptor levels and mRNA.
|
31775159 |
2020 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
The SNP, FAAH C385A (rs324420), was examined to determine whether its variance was associated with changes in craving and withdrawal after marijuana abstinence, craving after cue exposure, or sensitivity to the acute effects of marijuana.
|
19002671 |
2009 |
|
Marijuana Abuse
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers.
|
18705688 |
2008 |
|
Cannabis Dependence
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We investigated in adult Caucasians (N = 749) whether this FAAH variant altered the risk for trying, regular use of or dependence on cannabis, alcohol or nicotine, traditional "gateway" drugs.
|
17290447 |
2007 |
|
Drug abuse
|
0.350 |
GeneticVariation
|
group |
BEFREE |
Although a link between the FAAH P129T variant and human drug abuse has been reported, the extent of risk and specific types of substance addiction vulnerability remain to be determined.
|
16972078 |
2006 |
|
Drug abuse
|
0.350 |
GeneticVariation
|
group |
BEFREE |
These findings indicate that the natural 385A SNP in the human FAAH gene produces a mutant enzyme with reduced cellular stability, thus fortifying a potential link between functional abnormalities in the endocannabinoid system and drug abuse and dependence.
|
15254019 |
2004 |
|
Drug abuse
|
0.350 |
GeneticVariation
|
group |
BEFREE |
Enhanced brain levels of anandamide after treatment with inhibitors of fatty acid amide hydrolase, the main enzyme responsible for its degradation, seem to affect the rewarding and reinforcing actions of many drugs of abuse.
|
30050084 |
2019 |
|
Drug abuse
|
0.350 |
GeneticVariation
|
group |
BEFREE |
Collectively, these results suggest that genetic mutations in FAAH may constitute important risk factors for problem drug use and support a potential link between functional abnormalities in the endogenous cannabinoid system and drug abuse and dependence.
|
12060782 |
2002 |