CCNY, cyclin Y, 219771

N. diseases: 26; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease LHGDN Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease BEFREE Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 Biomarker disease CTD_human Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease LHGDN Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection. 18438405 2008
CUI: C0156147
Disease: Crohn's disease of large bowel
Crohn's disease of large bowel 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0678202
Disease: Regional enteritis
Regional enteritis 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0949272
Disease: IIeocolitis
IIeocolitis 		0.300 Biomarker disease CTD_human Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis. 18438405 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease BEFREE We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. 20176734 2010
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease BEFREE We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. 20176734 2010
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.040 AlteredExpression disease BEFREE The expression status of CCNY in lung cancer and its clinical significance remain unknown. 20596919 2010
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation. 20596919 2010
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.030 Biomarker disease BEFREE These studies suggest that CCNY may be a candidate biomarker of NSCLC and a possible therapeutic target for lung cancer treatment. 20596919 2010
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE The expression status of CCNY in lung cancer and its clinical significance remain unknown. 20596919 2010
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.030 AlteredExpression disease BEFREE The expression status of CCNY in lung cancer and its clinical significance remain unknown. 20596919 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE Overexpression of cyclin Y in non-small cell lung cancer is associated with cancer cell proliferation. 20596919 2010
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 GeneticVariation disease BEFREE We identified multiple previously unreported or unconfirmed disease associations, including known CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and IL26) that confer T1D risk and known UC loci (IL10 and CCNY) that confer CD risk. 20176734 2010
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE These data suggest that CCNY might play an important role in glioma tumorigenisis. 20441050 2010
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.430 GeneticVariation disease BEFREE Colon-only CD (n = 228) was compared with healthy controls: three of six UC SNPs (in MST1, HLA-DRA, and IL-23R) and 11 of 34 CD SNPs: in IRGM, NOD2 (rs2066845), CCNY, MST1, IL23R, PTPN22, C11orf30, ZNF365, PTPN2, PSMG1, and rs1456893 were significantly associated. 21830272 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease GWASCAT Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633 2011
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.420 GeneticVariation disease GWASDB Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. 21297633 2011
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.040 Biomarker disease BEFREE Hence, the aim of this study was to explore the potential role of CCNY in lung cancer. 21273179 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE CCNY mRNA expression associated with histologic types of NSCLC and promoted the malignant growth of lung cancer cell line in vivo and in vitro. 21273179 2011