|
Acute exacerbation of chronic obstructive airways disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Additional ensemble feature selection revealed the possibility to distinguish between CAP and AECOPD even if the patient with CAP had COPD, with a panel of CD45, CD28, CTLA4 (cytotoxic T-lymphocyte-associated protein 4), tumor necrosis factor-R-II, and CD16.
|
31617573 |
2020 |
|
CATARACT, ANTERIOR POLAR
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additional ensemble feature selection revealed the possibility to distinguish between CAP and AECOPD even if the patient with CAP had COPD, with a panel of CD45, CD28, CTLA4 (cytotoxic T-lymphocyte-associated protein 4), tumor necrosis factor-R-II, and CD16.
|
31617573 |
2020 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Crosslinking of CD32A<sup>131R</sup> -CR on T cells by cetuximab or panitumumab and CD16<sup>158F</sup> -CR T cells by cetuximab induced elimination of triple negative breast cancer (TNBC) MDA-MB-468 cells, and the secretion of interferon gamma and tumor necrosis factor alpha.
|
31479522 |
2020 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Crosslinking of CD32A<sup>131R</sup> -CR on T cells by cetuximab or panitumumab and CD16<sup>158F</sup> -CR T cells by cetuximab induced elimination of triple negative breast cancer (TNBC) MDA-MB-468 cells, and the secretion of interferon gamma and tumor necrosis factor alpha.
|
31479522 |
2020 |
|
Anemia, Sickle Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Forty-two adults with sickle cell disease (SCD) were recruited, with data extracted from the electronic medical record and peripheral blood analyzed by flow cytometry for total monocytes, monocyte subsets (CD14 high/CD16 low+ classical monocytes, CD14 high/CD16 high+ intermediate monocytes, and CD14 intermediate/CD16 high+ non-classical/inflammatory monocytes), and FcγR1 (CD64) expression.
|
31355970 |
2019 |
|
Carotid Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, the aim of this study was to investigate CD14++CD16-, CD14++CD16+, and CD14+CD16++ cells in patients with Stanford-A AAD and in patients with carotid artery stenosis (CAS).<i>Methods</i>.
|
31467936 |
2019 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our results highlight the importance of FcγRIIIa-dependent IFN-γ release in preclinical cytokine release assay for the prediction of CRS risk associated with therapeutic IgG1 antibodies.
|
29953319 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
There were no significant differences in gender, age, or number of metastasis cases between the survival group and the nonsurvival group (p > 0.05), but significant differences in pre-chemotherapy, post-chemotherapy, and the differences between pre- and post-chemotherapy circulating CD16+ CD56+ NK cells between the survival group and the nonsurvival group (p < 0.01, p < 0.01, and p < 0.05, respectively) were observed.
|
31493232 |
2019 |
|
Parasitic Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we have analyzed whether chronic <i>T. gondii</i> infection impacts the subset distribution and the phenotype of peripheral human monocytes <i>in vivo</i> and their responses to parasite infection <i>in vitro</i>.CD14<sup>+</sup> monocytes from <i>T. gondii</i>-seropositive blood donors expressed significantly less FcγRIII (CD16) than those from seronegative controls, but they did not show a shift in the distribution of classical, intermediate and non-classical monocyte subpopulations.
|
31316920 |
2019 |
|
Situs Inversus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Acute SIV infection was associated with increased FcγRIII expression which subsequently declined with disease progression.
|
31333668 |
2019 |
|
Chronic berylliosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism of FCGR3A gene in chronic beryllium disease.
|
30245507 |
2019 |
|
Pelvic Inflammatory Disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Three lymphocyte subsets (T CD3/CD4, B CD19 and NK CD16/CD56) had p-value < 0.05 and Odds Ratio (OR) indicating a risk at least two times higher for the diagnosis of a PID phenotype.
|
30908772 |
2019 |
|
Autoimmune neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among these 25 patients, 5 (20%) met the criteria for chronic neutropenia and 4 (80%) received the final diagnosis of autoimmune neutropenia based on the identification of the serum anti-CD16 antibodies.
|
29613972 |
2019 |
|
Hematologic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The use of tumor-specific antibodies that promote antibody-dependent cell-mediated cytotoxicity (ADCC) through the ligation of CD16 receptor on NK cells has become standard for many hematologic malignancies.
|
31569769 |
2019 |
|
Apraxia, Developmental Verbal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, the aim of this study was to investigate CD14++CD16-, CD14++CD16+, and CD14+CD16++ cells in patients with Stanford-A AAD and in patients with carotid artery stenosis (CAS).<i>Methods</i>.
|
31467936 |
2019 |
|
Multiple Sclerosis, Relapsing-Remitting
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we tested the hypothesis that FCGR3A and FCGR2A high-affinity polymorphisms predict clinical outcomes to alemtuzumab therapy in 85 patients with relapsing-remitting multiple sclerosis.
|
31682087 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GdA binds to blood CD16-CD56bright NK cells via its sialylated glycans and converts them to a dNK-like cells, which in turn regulate endothelial cell angiogenesis and trophoblast invasion via vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein 1 (IGFBP-1) secretion, respectively.
|
30597092 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this pilot study, circulating tumor cells (CTCs), CD16 positive atypical CTCs, and CTC clusters were captured and characterized in the blood of patients with PDAC before and after palliative first line chemotherapy by ScreenCell device, immunohistochemistry, and confocal microscopy analysis.
|
31552188 |
2019 |
|
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that both the PF/PB ratios of cytotoxic subpopulations CD57+ NK and CD16+ NK are useful as a prognostic factor of MPE.
|
30523401 |
2019 |
|
Venous Thromboembolism
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Monocyte subsets were assessed 12 (8.5-21.5) months after VTE using flow cytometry and were defined as classical (CD14++CD16-), intermediate (CD14++CD16+) and non-classical (CD14+CD16++).
|
30088349 |
2019 |
|
Deuteranomaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The FCGR3A V158F polymorphism is associated with CBD compared to BeS and controls and may impact lung function in CBD.
|
30245507 |
2019 |
|
Chordoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
RESULTS Here the authors demonstrate for the first time 1) that cetuximab in combination with NK cells can mediate ADCC of chordoma cells; 2) the influence of the NK CD16 polymorphism in cetuximab-mediated ADCC for chordoma cell lysis; 3) that engineered haNK cells-that is, cells transduced to express the CD16 V158 FcγRIIIa receptor-bind cetuximab with similar affinity to normal NK cells expressing the high-affinity VV allele; and 4) that irradiated haNK cells induce ADCC with cetuximab in chordoma cells.
|
28753113 |
2018 |
|
Cytomegalovirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Neither HCMV status, nor the extent of phenotypic evidence of adaptation to HCMV infection significantly affected mean levels of ADCC or CD16-mediated NK cell degranulation and IFN-γ production compared between the HIV-infected groups.
|
30483249 |
2018 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
anti-FCGR3: anti-FCGR3 with neutralizing antibody; Ctrl-ESC: untreated ESCs; CXCL8: C-X-C motif chemokine ligand 8; ectoESC: ESCs from ectopic lesion; ELM: ectopic lesion microenvironment; EMS: endometriosis; ESCs: endometrial stromal cells; eutoESC:eutopic ESCs; HCK: hematopoietic cellular kinase; HCK(OE): overexpression of HCK; IFNG: interferon gamma; IL23A (OE): overexpression of IL23A; KLRK1: Killer cell lectin like receptor K1; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; 3 -MA: 3-methyladenine; 3-MA-ESC: 3-MA-treated ESCs; MIR1185-1-3p<sup>+</sup>: overexpression of HsMIR1185-1-3p; NK: natural killer; normESCs: normal ESCs; Rap-ESC:rapamycin-treated ESCs; PCNA: proliferating cell nuclear antigen; PF: peritoneal fluid; SFKs: SRC family of cytoplasmic tyrosine kinases; si-HCK: silencing of HCK; siIL23A: silencing of IL23A; USCs: uterus stromal cells.
|
29962266 |
2018 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
The inflammation intensity in the liver decreased with IgG depletion and the lupus IgG-induced liver inflammation in FcγRIII-deficient mice was comparatively low; while, inflammation was increased in FcγRIIb-deficient mice.
|
29988500 |
2018 |