Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene.
|
2824415 |
1987 |
Mammary Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
|
21936542 |
2011 |
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
LHGDN |
The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells.
|
12841847 |
2003 |
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
BEFREE |
While overexpression of FGF-4 in the MCF-7 breast carcinoma cell line confers the ability to form spontaneously metastasizing tumors in ovariectomized nude mice without estrogen supplementation and in mice that receive tamoxifen pellets, the response of a cell to individual FGFs can be controlled at multiple levels, and the significance of FGF-1 expression in human breast tumors is uncertain.
|
9366526 |
1997 |
Mammary Neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Using this rapid PCR/HPIEX technique, we have identified amplification and deletion of the FGF-2 gene and the FGF-3, FGF-4 and c-erb-B2 oncogenes in human tumours of the breast, ovary and endometrium.
|
8962718 |
1996 |
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
|
21936542 |
2011 |
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.
|
21936542 |
2011 |
Neoplasm of uncertain or unknown behavior of breast
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Breast adenocarcinoma
|
0.300 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Case 1: A patient with locally unresectable HCC showed significant response induced by sorafenib, which allowed complete surgical resection.This tumor tested positive for FGF4.
|
29277815 |
2018 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HST/HER2 ratios did not predict the presence of HST protein, which was found in 46 (25%) of 187 tumors.
|
18592003 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
EMS1, CCND1, and FGF3/FGF4, which are all located on 11q13, were amplified in 7, 5, and 4 of 20 ESCC, respectively, and they were coamplified in 3 tumors.
|
14499691 |
2003 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
FGF3 and FGF4 showed a significantly higher frequency of amplification in hypopharyngeal tumors (P =.006 and P =.0002, respectively).
|
11568558 |
2001 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This makes uncertain its involvement in tumour aetiology, although several in-vitro studies link Fgf4 overexpression to malignant transformation and metastatization of culture cells.
|
11146552 |
2000 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The histopathology and neovascularization did not appreciably differ between xenograft tumors derived from FGF4 over-expressing versus control transfectants.
|
9715278 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have previously shown that fibroblast growth factor (FGF)-1-, FGF-4-, or vascular endothelial growth factor (VEGF/VPF)-transfected MCF-7 breast carcinoma cells growing as tumors in nude mice are tamoxifen resistant and/or estrogen independent.
|
9846989 |
1998 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To get more insight into the role of 11q13 amplification in bladder tumour development, we have studied the level of amplification and expression of 4 (protoonco)genes lying within the amplicon; cyclin D1, FGF3, FGF4 and EMS1 DNA amplification was found in 5/46 tumours.
|
8622895 |
1996 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The assessment was that hst-1 gene amplification within each individual primary tumor was identical in all 27 cases (100%) and that the intensity of amplification in the primary tumor matched that in the metastatic lesion in 18 of 22 cases (82%).
|
8523818 |
1995 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Survival rates for patients bearing tumors with and without hst-1 gene amplification were calculated by the Kaplan-Meier method and evaluated by the log-rank test.
|
8010723 |
1994 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Parental MCF-7 cells were transfected with an expression vector for beta-galactosidase, conferring the ability to convert the chromogenic substrate, 5-bromo-4-chloro-3-indoyl-beta-galactoside, to a blue color and allowing the detection of their presence within tumors developing after coinoculation with fibroblast growth factor 4-transfected cells.
|
8481920 |
1993 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Coamplification of GST pi, HSTF1 and INT2 was observed in five tumors, and coamplification of GST pi and HSTF1 without amplification of INT2 in another tumor.
|
1826346 |
1991 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, known genes within the amplified region, such as the FGF-related oncogenes INT-2 and HST-1, are very rarely expressed in these tumors.
|
2011398 |
1991 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, chi 2 test).
|
1706218 |
1991 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast to controls, K-fgf-transfected cells secrete significant amounts of biologically active K-fgf protein into the growth media, show up to 50-fold increased colony formation in soft agar, and grow into rapidly progressing, highly vascularized tumors in athymic nude mice.
|
1964794 |
1990 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Only four proto-oncogenes were found to be amplified in at least one tumor each: HST and INT2 (x3), MYC (x2-3), and FES (x greater than 10).
|
2177639 |
1990 |