FGF4, fibroblast growth factor 4, 2249

N. diseases: 86; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 GeneticVariation group BEFREE Although hst gene rearrangements and deletions of 11q13 are not associated with sporadic PRL-cell adenoma formation, a single patient was detected with a partial loss of chromosome 11, including the putative MEN-1 site. 8100831 1993
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.010 GeneticVariation group BEFREE Here, we report coamplification of the cyclin D and hst-1 genes in 5 of 20 (25%) human squamous esophageal tumors. 1533816 1992
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 GeneticVariation disease BEFREE We report the independent isolation of a rearranged FGF-4 gene from a patient with chronic myeloid leukaemia. 7994085 1994
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 GeneticVariation group BEFREE Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene. 2824415 1987
CUI: C0027533
Disease: Neck Neoplasms
Neck Neoplasms 		0.010 GeneticVariation group BEFREE The CCND1-ORAOV1-FGF19-FGF4-FGF3-TMEM16A-FADD-PPFIA1-CTTN (EMS1) locus at human chromosome 11q13.3 is amplified in head and neck tumors, esophageal cancer, Kaposi's sarcoma, bladder tumors, breast cancer, and liver cancer. 15942670 2005
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 GeneticVariation disease BEFREE Five clones, containing the genomic hst gene, were isolated from a human cosmid library constructed from leukocyte DNA from a patient with acute leukemia. 3030292 1987
CUI: C0153685
Disease: Secondary malignant neoplasm of kidney
Secondary malignant neoplasm of kidney 		0.010 GeneticVariation disease BEFREE Although rearrangement of the gene was not detected in any of these samples, amplification of the hst-1 gene was found in 4 samples of tumors, including an invasive bladder cancer, both primary esophageal cancer and its lymph node metastasis, and kidney metastasis of an esophageal cancer. 3133332 1988
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE In an attempt to probe the significance of HST and INT-2 gene amplification in human breast carcinomas, we have surveyed the amplification status of five molecular markers located on the long arm of chromosome 11 (BCL-1, HST, INT-2 & SEA on 11q13, and ETS-1 on 11q23) in a population of 297 mammary tumors. 2181375 1990
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Because HST is described as an endogenous pan-HER inhibitor, the presence of this protein in breast carcinomas may portent the inefficiency of exogenous efforts to block HER2 dimerization, whereas its absence may justify such interventions. 18592003 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE The glutathione S-transferase gene (GST pi) is located on the same chromosome band (11q13) as proto-oncogenes INT2 and HSTF1 which are frequently amplified in breast cancer. 1826346 1991
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE The CCND1-FGF19-FGF4-FGF3 gene cluster in human chromosome 11q13 is amplified in breast cancer, squamous cell carcinoma of head and neck, and bladder tumors, and is also translocated in parathyroid tumors and B-cell lymphoma. 12429977 2002
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. 8481921 1993
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE Although evaluation of the clinical significance of HST amplification and expression must await long-term follow-up of the patients, we suggest that HST gene product could play a role in development and/or progression of human breast cancer. 2474139 1989
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.600 Biomarker disease BEFREE BCL1 and two proto-oncogenes, INT2 and HST, were previously found to be coamplified in approximately 1/5 breast carcinomas. 2071147 1991
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.560 Biomarker disease BEFREE GST pi gene is frequently coamplified with INT2 and HSTF1 proto-oncogenes in human breast cancers. 1826346 1991
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.560 Biomarker disease BEFREE The CCND1-FGF19-FGF4-FGF3 gene cluster in human chromosome 11q13 is amplified in breast cancer, squamous cell carcinoma of head and neck, and bladder tumors, and is also translocated in parathyroid tumors and B-cell lymphoma. 12429977 2002
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.560 Biomarker disease CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.560 Biomarker disease BEFREE Although evaluation of the clinical significance of HST amplification and expression must await long-term follow-up of the patients, we suggest that HST gene product could play a role in development and/or progression of human breast cancer. 2474139 1989
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.560 Biomarker disease BEFREE Quantitative demonstration of spontaneous metastasis by MCF-7 human breast cancer cells cotransfected with fibroblast growth factor 4 and LacZ. 8481921 1993
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease CTD_human Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. 25822088 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.340 Biomarker disease BEFREE We examined the mRNA expressions of FGF19, FGFR4, klotho-beta (KLB), cyclin D1 (CCND1) and FGF4 in 151 surgically resected, primary unifocal HCCs through quantitative real-time polymerase chain reaction. 30698907 2019
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.330 Biomarker group BEFREE Using this rapid PCR/HPIEX technique, we have identified amplification and deletion of the FGF-2 gene and the FGF-3, FGF-4 and c-erb-B2 oncogenes in human tumours of the breast, ovary and endometrium. 8962718 1996
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.330 Biomarker group CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2011
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker disease CTD_human Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase. 21936542 2011