|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In an attempt to probe the significance of HST and INT-2 gene amplification in human breast carcinomas, we have surveyed the amplification status of five molecular markers located on the long arm of chromosome 11 (BCL-1, HST, INT-2 & SEA on 11q13, and ETS-1 on 11q23) in a population of 297 mammary tumors.
|
2181375 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The fact that we never observed amplification of HST & INT-2 independently of BCL-1, which in turn can be amplified solely, suggests the presence, between HST/INT-2 and BCL-1, of a genetic element which could be important in the development of a subset of mammary tumors.
|
2181375 |
1990 |
|
Carcinoma
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Concerning band q13: (i) 50 tumors (approximately 17%) were co-amplified for BCL-1, HST & INT-2; (ii) in 3 cases, amplification extended to the SEA gene; (iii) in 6 carcinomas, BCL-1 was the only amplified marker.
|
2181375 |
1990 |
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Although evaluation of the clinical significance of HST amplification and expression must await long-term follow-up of the patients, we suggest that HST gene product could play a role in development and/or progression of human breast cancer.
|
2474139 |
1989 |
|
Malignant neoplasm of breast
|
0.560 |
Biomarker
|
disease |
BEFREE |
Although evaluation of the clinical significance of HST amplification and expression must await long-term follow-up of the patients, we suggest that HST gene product could play a role in development and/or progression of human breast cancer.
|
2474139 |
1989 |
|
Bladder Neoplasm
|
0.020 |
Biomarker
|
disease |
BEFREE |
None of 37 hematopoietic neoplasms, one out of 13 melanomas (8%), three out of 43 bladder tumors (7%) and 41 out of 238 breast carcinomas (17%) contained amplified FGF-related sequences, namely HST and INT2.
|
2474139 |
1989 |
|
Carcinoma
|
0.060 |
GeneticVariation
|
group |
BEFREE |
No coamplification of the hst-1 and int-2 genes was detected in gastric carcinomas and colorectal carcinomas.
|
2529025 |
1989 |
|
Carcinogenesis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
These results suggest that amplification of chromosomal locus of the hst-1 and int-2 genes might participate in carcinogenesis, in progression, and particularly in metastasis of esophageal carcinomas.
|
2529025 |
1989 |
|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
No coamplification of the hst-1 and int-2 genes was detected in gastric carcinomas and colorectal carcinomas.
|
2529025 |
1989 |
|
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
(2) The human homolog of int-2, located on chromosome 11q13, is frequently amplified in human primary tumors and is comprised in an amplification unit encompassing the hst gene, which is often coamplified; the amplification at the 11q13 locus in breast carcinomas correlates with a poor outcome of the disease.
|
2677918 |
1989 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene.
|
2824415 |
1987 |
|
Liver neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene.
|
2824415 |
1987 |
|
Liver carcinoma
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.
|
2856253 |
1988 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
One of the integrated HBV DNAs was found to lie close to the hst-1, and the hst-1 and the integrated HBV DNA were found to be co-amplified.
|
2856253 |
1988 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
Here, cosmid clones containing the hst gene were isolated directly from normal human leukocyte DNA and from T361-2nd-1 cells, a secondary transformant of NIH3T3 cells induced by transfection of DNA from a stomach cancer.
|
2895649 |
1988 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, cosmid clones containing the hst gene were isolated directly from normal human leukocyte DNA and from T361-2nd-1 cells, a secondary transformant of NIH3T3 cells induced by transfection of DNA from a stomach cancer.
|
2895649 |
1988 |
|
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Restriction map of the hst gene from normal leukocyte DNA was identical with that from leukocyte DNA of a leukemia patient, while the hst gene from T361-2nd-1 cells was rearranged at the 168th nucleotide upstream of the TATA box.
|
2895649 |
1988 |
|
Childhood Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Restriction map of the hst gene from normal leukocyte DNA was identical with that from leukocyte DNA of a leukemia patient, while the hst gene from T361-2nd-1 cells was rearranged at the 168th nucleotide upstream of the TATA box.
|
2895649 |
1988 |
|
Malignant neoplasm of stomach
|
0.040 |
Biomarker
|
disease |
BEFREE |
The hst gene was originally identified as a transforming gene in DNAs from human stomach cancers and from a noncancerous portion of stomach mucosa by DNA-mediated transfection assay using NIH3T3 cells. cDNA clones of hst were isolated from the cDNA library constructed from poly(A)+ RNA of a secondary transformant induced by the DNA from a stomach cancer.
|
2953031 |
1987 |
|
Stomach Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The hst gene was originally identified as a transforming gene in DNAs from human stomach cancers and from a noncancerous portion of stomach mucosa by DNA-mediated transfection assay using NIH3T3 cells. cDNA clones of hst were isolated from the cDNA library constructed from poly(A)+ RNA of a secondary transformant induced by the DNA from a stomach cancer.
|
2953031 |
1987 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five clones, containing the genomic hst gene, were isolated from a human cosmid library constructed from leukocyte DNA from a patient with acute leukemia.
|
3030292 |
1987 |
|
Malignant neoplasm of stomach
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer.
|
3108211 |
1987 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer.
|
3108211 |
1987 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer.
|
3108211 |
1987 |
|
Secondary malignant neoplasm of kidney
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Although rearrangement of the gene was not detected in any of these samples, amplification of the hst-1 gene was found in 4 samples of tumors, including an invasive bladder cancer, both primary esophageal cancer and its lymph node metastasis, and kidney metastasis of an esophageal cancer.
|
3133332 |
1988 |