FGF4, fibroblast growth factor 4, 2249

N. diseases: 86; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 Biomarker disease BEFREE If these results translated favourably to humans, FGF-4 gene therapy may be a therapeutic option for patients with dilated heart failure. 11909005 2002
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE If these results translated favourably to humans, FGF-4 gene therapy may be a therapeutic option for patients with dilated heart failure. 11909005 2002
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.010 Biomarker disease LHGDN Adherent stromal layers from 13 patients with AML and from six non-leukemic controls were established with 3ng/ml of FGF-4, EGF or TGF-beta1. 12163055 2002
CUI: C0008497
Disease: Choriocarcinoma
Choriocarcinoma 		0.010 Biomarker disease BEFREE All cases of embryonal carcinoma (14 cases), yolk sac tumor (3 cases), and choriocarcinoma (3 cases) showed positive immunostaining for FGF8, FGF4, and FGFR1. 11764380 2001
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.010 AlteredExpression disease BEFREE FGF4 and INT2 oncogenes are amplified and expressed in Kaposi's sarcoma. 10786811 2000
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 Biomarker group BEFREE Amplification of Int-2 was detectable (7 of 9 cases) in 78% of the HPV-positive carcinomas, whereas no virus infection could be found in the five cases with amplified Hst-1 only. 11016685 2000
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.010 AlteredExpression phenotype BEFREE This makes uncertain its involvement in tumour aetiology, although several in-vitro studies link Fgf4 overexpression to malignant transformation and metastatization of culture cells. 11146552 2000
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.010 AlteredExpression disease BEFREE RA-treatment repressed endogenous but not exogenous FGF4 expression. 9715278 1998
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 AlteredExpression disease BEFREE RA-treatment repressed endogenous but not exogenous FGF4 expression. 9715278 1998
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.010 AlteredExpression disease BEFREE To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed. 8685603 1996
CUI: C0032227
Disease: Pleural effusion disorder
Pleural effusion disorder 		0.010 Biomarker group BEFREE FISH analysis with INT2/FGF3 and HST1/FGF4 probes revealed that these protooncogenes were coamplified in the hsrs of BHI and BHII. 8946196 1996
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.010 AlteredExpression disease BEFREE However, the levels of FGF-4 mRNA expression were significantly (p < 0.05) lower than those of FGF-1 and -2 mRNAs in both endometrial cancers and normal endometria. 8685603 1996
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 AlteredExpression phenotype BEFREE To investigate whether growth, invasion and metastasis of endometrial cancer cells is associated with neovascularization, the expressions of fibroblast growth factor-1 (acidic FGF), -2 (basic FGF) and -4 (hst-1) mRNAs and FGF-2 in endometrial cancers and normal endometria as controls were determined by reverse transcription-polymerase chain reaction-Southern blot and ELISA, respectively, and the relationships between their expressions and histological grades, grades of myometrial invasion or clinical stages of endometrial cancers were analyzed. 8685603 1996
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 GeneticVariation disease BEFREE We report the independent isolation of a rearranged FGF-4 gene from a patient with chronic myeloid leukaemia. 7994085 1994
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 GeneticVariation group BEFREE Although hst gene rearrangements and deletions of 11q13 are not associated with sporadic PRL-cell adenoma formation, a single patient was detected with a partial loss of chromosome 11, including the putative MEN-1 site. 8100831 1993
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.010 GeneticVariation group BEFREE Here, we report coamplification of the cyclin D and hst-1 genes in 5 of 20 (25%) human squamous esophageal tumors. 1533816 1992
CUI: C0206664
Disease: Teratocarcinoma
Teratocarcinoma 		0.010 AlteredExpression disease BEFREE Differentiation associated modulation of K-FGF expression in a human teratocarcinoma cell line and in primary germ cell tumours. 2009969 1991
CUI: C1335059
Disease: testicular nonseminoma
testicular nonseminoma 		0.010 AlteredExpression disease BEFREE A significant association between tumor stage and hst-1 expression in the nonseminoma group was found (P = 0.0002, chi 2 test). 1706218 1991
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 Biomarker disease BEFREE One of the integrated HBV DNAs was found to lie close to the hst-1, and the hst-1 and the integrated HBV DNA were found to be co-amplified. 2856253 1988
CUI: C0153685
Disease: Secondary malignant neoplasm of kidney
Secondary malignant neoplasm of kidney 		0.010 GeneticVariation disease BEFREE Although rearrangement of the gene was not detected in any of these samples, amplification of the hst-1 gene was found in 4 samples of tumors, including an invasive bladder cancer, both primary esophageal cancer and its lymph node metastasis, and kidney metastasis of an esophageal cancer. 3133332 1988
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 AlteredExpression disease BEFREE The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer. 3108211 1987
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.010 GeneticVariation group BEFREE Through hybridization with known oncogene probes, the transforming gene in one hepatoma was found to be the human hst gene. 2824415 1987
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 GeneticVariation disease BEFREE Five clones, containing the genomic hst gene, were isolated from a human cosmid library constructed from leukocyte DNA from a patient with acute leukemia. 3030292 1987
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 AlteredExpression disease BEFREE The hst gene was also responsible for acquisition of the transforming activity in DNA samples from 2 other stomach cancers and one colon cancer. 3108211 1987
CUI: C0238198
Disease: Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors 		0.020 AlteredExpression group BEFREE CRISPR-mediated excision of the corresponding CTCF motifs in an SDH-intact GIST model disrupted the boundary between enhancer and oncogene, and strongly upregulated FGF4 expression. 31666694 2019