Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanism dissection revealed that infiltrating CD4(+) T cells might function through the modulation of FGF11→miRNA-541 signals to suppress PCa androgen receptor (AR) signals.
|
25135278 |
2015 |
Brugada Syndrome (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the basis of the recent demonstration that fibroblast growth factor (FGF) homologous factors (FHFs; FGF11-FGF14) regulate cardiac Na(+) and Ca(2+) channel currents, we hypothesized that FHFs are candidate BrS loci.
|
24096171 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, perturbation of miR-342-3p/FGF11 cascade by hyperinsulinemia plays a causative role in the induction of vascular dysfunction in T2DM.
|
29852165 |
2018 |
Diabetic Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, miR-24-3p inhibitor rescued the suppression of si-circ_0080425 on FGF11, suggesting that circ_0080425 competitive binding to miR-24-3p could release FGF11 from miR-24-3p suppression, which subsequently promoted DN progression.In conclusion, we have reported a novel circ_0080425-miR-24-3p-FGF11 axis, and explored the underlying mechanism in regulating DN pathogenesis.
|
31680239 |
2020 |
Giant Cell Tumor of Bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FGF11 was also abundantly expressed in osteoclasts within the rheumatoid synovium and in giant cell tumour of bone.
|
28097375 |
2017 |
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, perturbation of miR-342-3p/FGF11 cascade by hyperinsulinemia plays a causative role in the induction of vascular dysfunction in T2DM.
|
29852165 |
2018 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanism dissection revealed that infiltrating CD4(+) T cells might function through the modulation of FGF11→miRNA-541 signals to suppress PCa androgen receptor (AR) signals.
|
25135278 |
2015 |
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our findings suggest that exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in NPC.
|
27538493 |
2016 |
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling.
|
25135278 |
2015 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Collectively, our findings suggest that exosomal miR-24-3p is involved in tumour pathogenesis by mediating T-cell suppression via repression of FGF11, and may serve as a potential prognostic biomarker in NPC.
|
27538493 |
2016 |
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanism dissection revealed that infiltrating CD4(+) T cells might function through the modulation of FGF11→miRNA-541 signals to suppress PCa androgen receptor (AR) signals.
|
25135278 |
2015 |
Testosterone measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic Association Study of Eight Steroid Hormones and Implications for Sexual Dimorphism of Coronary Artery Disease.
|
31169883 |
2019 |