Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A simple and fast method for the simultaneous detection of nine fibroblast growth factor receptor 3 mutations in bladder cancer and voided urine.
|
16278395 |
2005 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Several genetic changes may occur in bladder cancer, but activating mutations in the fibroblast growth factor receptor 3 (FGFR3) genes are the most common and most specific genetic abnormality in bladder cancer.
|
20822928 |
2013 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
PATIENT SUMMARY: We propose that APOBEC-mediated mutagenesis can generate clinically relevant driver mutations even within suboptimal motifs, such as in the case of FGFR3 S249C, one of the most common mutations in bladder cancer.
|
30975452 |
2019 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The GSE41035 dataset downloaded from Gene Expression Omnibus was used to identify the differentially expressed genes (DEGs) between bladder cancer cell line RT112 with or without depletion of FGFR3, and gene ontology enrichment analysis was performed.
|
28320388 |
2017 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results show a link between germline variants, somatic mutations of FGFR3 and risk of UBC.
|
20348956 |
2010 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
TP53 and FGFR3 Gene Mutation Assessment in Urine: Pilot Study for Bladder Cancer Diagnosis.
|
26254388 |
2015 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
An example of a TM domain pathogenic mutation is the Ala391-->Glu mutation in fibroblast growth factor receptor 3 (FGFR3), linked to Crouzon syndrome with acanthosis nigricans, as well as to bladder cancer.
|
16384584 |
2006 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Incidence of fibroblast growth factor receptor 3 gene (FGFR3) A248C, S249C, G372C, and T375C mutations in bladder cancer.
|
21264819 |
2011 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Silencing or inhibition of mutant FGFR3 in bladder cancer cell lines is associated with decreased malignant potential, confirming its important driver role in UC.
|
30952872 |
2019 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The two most important developments are the identification of a mutation in the fibroblast growth factor receptor 3 gene in more than 50% of urothelial carcinomas and the discovery of cDNA profiles characteristic of different subsets of bladder cancer.
|
19031931 |
2009 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
1-tert-butyl-3-[6-(3,5-dimethoxy-phenyl)-2-(4-diethylamino-butylamino)-pyrido[2,3-d]pyrimidin-7-yl]-urea (PD173074), a selective tyrosine kinase inhibitor of fibroblast growth factor receptor-3 (FGFR3), inhibits cell proliferation of bladder cancer carrying the FGFR3 gene mutation along with up-regulation of p27/Kip1 and G1/G0 arrest.
|
19955487 |
2010 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
FGFR3 analyses did not reveal any mutation in the urothelium from neither the control group nor the bladder cancer group.
|
19621447 |
2009 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The Diagnostic and Prognostic Performance of Urinary FGFR3 Mutation Analysis in Bladder Cancer Surveillance: A Prospective Multicenter Study.
|
26364695 |
2015 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
FGFR3 and Tp53 mutations have been proposed as defining two alternative pathways in the pathogenesis of transitional bladder cancer.
|
16061860 |
2005 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We carried out a meta-analysis of published findings for FGFR3 and TP53 mutations in bladder cancer (535 tumours, 6 publications) and additional unpublished data for 382 tumours.
|
23272046 |
2012 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Somatic FGFR3 Mutations Distinguish a Subgroup of Muscle-Invasive Bladder Cancers with Response to Neoadjuvant Chemotherapy.
|
29941343 |
2018 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Usefulness of droplet digital PCR and Sanger sequencing for detection of FGFR3 mutation in bladder cancer.
|
31377167 |
2019 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Recent developments in the field of molecular mutational pathway analyses based on next generation sequencing technology together with classic data derived from the description of mutations in the FGFR3 (fibroblast growth factor receptor 3) gene, mutations on TP53 gene, and cDNA technology profiling data gives support to a differentiated taxonomy of bladder cancer.
|
25654736 |
2015 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the possible prognostic value of the recently discovered fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer.
|
11245416 |
2001 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The detection of FGFR3 mutations in FUH further supports the role of this lesion as precursor of papillary bladder cancer.
|
16570285 |
2006 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression.All statistical tests were two-sided.
|
26374428 |
2015 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Massively parallel sequencing of sperm DNA showed that levels of the FGFR3 mutation increase with paternal age and that the mutation spectrum at the Lys650 codon is similar to that observed in bladder cancer.
|
19855393 |
2009 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In bladder carcinoma, we recently identified FGFR3 mutations in 41% of tumours, making this the most frequently mutated putative oncogene identified in bladder cancer to date.
|
11466624 |
2001 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Search terms included 'FGFR3 genomic alterations' and 'urothelial cancer' or 'bladder cancer'.
|
27271022 |
2016 |
Malignant neoplasm of urinary bladder
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we looked for FGFR3 mutations in these two animal models of bladder cancer.
|
15690367 |
2005 |