RRAS2, RAS related 2, 22800

N. diseases: 48; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.600 CausalMutation disease CGI
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.600 Biomarker disease GENOMICS_ENGLAND
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.600 GeneticVariation disease UNIPROT
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.500 Biomarker disease GENOMICS_ENGLAND
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.500 CausalMutation disease CGI
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.400 CausalMutation disease CGI
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.400 CausalMutation disease CLINVAR
CUI: C0496920
Disease: Neoplasm of uncertain or unknown behavior of ovary
Neoplasm of uncertain or unknown behavior of ovary 		0.300 CausalMutation disease CGI
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.300 Biomarker disease GENOMICS_ENGLAND
CUI: C4551602
Disease: Noonan Syndrome 1
Noonan Syndrome 1 		0.100 CausalMutation disease CLINVAR
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 GeneticVariation group BEFREE TC21 is a Ras-like GTPase with high oncogenic potential that is found mutated in some human tumors and overexpressed in breast cancer cell lines. 10557073 1999
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.030 AlteredExpression disease BEFREE TC21 is a Ras-like GTPase with high oncogenic potential that is found mutated in some human tumors and overexpressed in breast cancer cell lines. 10557073 1999
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 AlteredExpression disease BEFREE TC21 is a Ras-like GTPase with high oncogenic potential that is found mutated in some human tumors and overexpressed in breast cancer cell lines. 10557073 1999
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 AlteredExpression group BEFREE TC21 nuclear expression increased from normal oral tissues to leukoplakia and frank malignancy (P < 0.001). 20040018 2010
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 AlteredExpression group BEFREE TC21 nuclear expression increased from normal oral tissues to leukoplakia and frank malignancy (P < 0.001). 20040018 2010
CUI: C0023531
Disease: Leukoplakia
Leukoplakia 		0.010 AlteredExpression disease BEFREE TC21 overexpression was observed in 74.2% leukoplakia with no dysplasia, 75.9% dysplasias and 79.5% OSCCs in comparison with normal oral tissues. 20040018 2010
CUI: C0023269
Disease: leiomyosarcoma
leiomyosarcoma 		0.020 GeneticVariation disease BEFREE TC21 is a ras family member that shares close homology to H-, K- and N-ras, and activating mutations have been found in ovarian carcinoma and leiomyosarcoma cell lines. 9703274 1998
CUI: C0278607
Disease: Adult Leiomyosarcoma
Adult Leiomyosarcoma 		0.020 GeneticVariation disease BEFREE TC21 is a ras family member that shares close homology to H-, K- and N-ras, and activating mutations have been found in ovarian carcinoma and leiomyosarcoma cell lines. 9703274 1998
CUI: C0279986
Disease: Childhood Leiomyosarcoma
Childhood Leiomyosarcoma 		0.020 GeneticVariation disease BEFREE TC21 is a ras family member that shares close homology to H-, K- and N-ras, and activating mutations have been found in ovarian carcinoma and leiomyosarcoma cell lines. 9703274 1998
CUI: C0023269
Disease: leiomyosarcoma
leiomyosarcoma 		0.020 GeneticVariation disease BEFREE A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line. 7478545 1995
CUI: C0278607
Disease: Adult Leiomyosarcoma
Adult Leiomyosarcoma 		0.020 GeneticVariation disease BEFREE A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line. 7478545 1995
CUI: C0279986
Disease: Childhood Leiomyosarcoma
Childhood Leiomyosarcoma 		0.020 GeneticVariation disease BEFREE A novel insertional mutation in the TC21 gene activates its transforming activity in a human leiomyosarcoma cell line. 7478545 1995
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.030 GeneticVariation disease BEFREE A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. 19047159 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.030 GeneticVariation disease BEFREE A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. 19047159 2008
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.020 Biomarker phenotype BEFREE Aberrant function of RRAS2 drives malignant transformation in a various of cancers. 31517733 2019