|
Malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we first identified that melatonin selectively blocked activating transcription factor 6 (ATF-6) and then inhibited cyclooxygenase-2 (COX-2) expression, leading to enhanced liver cancer cell apoptosis under ER stress condition.
|
28246472 |
2017 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RSV promoted the expression of phosphorylated protein kinase R‑like endoplasmic reticulum kinase (p‑PERK), 78 kDa glucose‑regulated protein (GRP78) and activating transcription factor 6α (ATF6α), which accelerated the severity and process of fibrosis in bleomycin‑induced animal models.
|
28498407 |
2017 |
|
Retinal Dystrophies
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Here we report two siblings affected by an IRD phenotype and a novel homozygous c.1691A>G (p.(Asp564Gly)) ATF6 (activating transcription factor 6A) missense substitution identified by whole exome sequencing analysis.
|
28812650 |
2017 |
|
Endothelial dysfunction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Obese adults with vascular endothelial dysfunction have greater endothelial cells activation of unfolded protein response stress sensors, RNA-dependent protein kinase-like ER eukaryotic initiation factor-2alpha kinase (PERK) and activating transcription factor-6.
|
28585197 |
2017 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
We concluded that the ATF6 UPR branch is crucial to ischemic stroke outcome.
|
27217380 |
2017 |
|
Pancreatic intraepithelial neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The unfolded protein response proteins GRP78, ATF6 and XBP1s were found expressed in CP and PDAC peritumoral tissues, but in contrast to AGR2, their expression was switched off during TC and PanIN formation.
|
27941872 |
2017 |
|
Renal steatosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We combined gene expression profiling, biochemical assays, and untargeted lipidomics to understand the basis of stress-dependent lipid accumulation, taking advantage of enhanced hepatic and renal steatosis in mice lacking the ER stress sensor ATF6α.
|
28564599 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
|
26716508 |
2016 |
|
Hepatitis B
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic Variations in XRCC4 (rs1805377) and ATF6 (rs2070150) are not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.
|
26925648 |
2016 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with these observations, IFN-γ and chemotherapeutics failed to activate autophagy in CLL patient samples lacking ATF6 and/or C/EBP-β.
|
27590344 |
2016 |
|
Complete atrioventricular block
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The present study was conducted to evaluate any association between SNP frequencies in two genes, XRCC4 (rs1805377) and ATF6 (rs2070150), and the risk of CHB and HCC development in Thai patients.
|
26925648 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
|
26716508 |
2016 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
|
26716508 |
2016 |
|
Sjogren's Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Pro-inflammatory cytokines enhance ERAD and ATF6α pathway activity in salivary glands of Sjögren's syndrome patients.
|
27461470 |
2016 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma.
|
26716508 |
2016 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interferon regulatory factor 2 (IRF2) and cell death‑inducing DFFA‑like effector b (CIDEB), which are regulated by signal transducer and activator of transcription 3 and myc‑associated factor X, were identified as common DEGs for CAD. miR‑455‑5p, miR‑455‑3p and miR‑1257, which are involved in the major histocompatibility complex (MHC)protein assembly pathway and peptide antigen assembly with MHC class I protein complex pathway, may regulate various miRNAs and target genes, including pro‑opiomelancortin (POMC), toll‑like receptor 4 (TLR4), interleukin 10 (IL10), activating transcription factor 6 (ATF6) and calreticulin (CALR).
|
26936111 |
2016 |
|
Diabetic Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN. sXBP1 lies downstream of insulin signalling and attenuating podocyte insulin signalling by genetic ablation of the insulin receptor or the regulatory subunits phosphatidylinositol 3-kinase (PI3K) p85α or p85β impairs sXBP1 nuclear translocation and exacerbates DN.
|
25754093 |
2015 |
|
Lupus Vulgaris
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GRP78 and ER stress-signaling molecules, such as PERK, p-eIF2α, IRE1, and ATF6 decreased, whereas CHOP levels increased in lupus T cells in response to TG.
|
25516752 |
2015 |
|
Lupus Erythematosus, Discoid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GRP78 and ER stress-signaling molecules, such as PERK, p-eIF2α, IRE1, and ATF6 decreased, whereas CHOP levels increased in lupus T cells in response to TG.
|
25516752 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GRP78 and ER stress-signaling molecules, such as PERK, p-eIF2α, IRE1, and ATF6 decreased, whereas CHOP levels increased in lupus T cells in response to TG.
|
25516752 |
2015 |
|
Age-related cataract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the lens epithelium of the high myopia-related cataract group and the age related cataract group, the mRNA and soluble protein expression of αA- and αB-crystallin were both decreased; additionally, the protein levels of ATF6, p-eIF2α and p-IRE1α and the gene expression levels of spliced XBP1, GRP78, ATF6 and ATF4 were greatly increased relative to the normal control.
|
26351848 |
2015 |
|
Lupus Erythematosus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GRP78 and ER stress-signaling molecules, such as PERK, p-eIF2α, IRE1, and ATF6 decreased, whereas CHOP levels increased in lupus T cells in response to TG.
|
25516752 |
2015 |
|
Cone dysfunction syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Atf6(-/-) mice have normal retinal morphology and function at a young age but develop rod and cone dysfunction with increasing age.
|
26029869 |
2015 |
|
Inclusion Body Myopathy, Sporadic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we demonstrate for the first time that UPR is activated in s-IBM muscle biopsies, since there was 1) increased activating transcription factor 4 (ATF4) protein and increased mRNA of its target C/EBP homologous protein; 2) cleavage of the ATF6 and increased mRNA of its target glucose-regulated protein 78; and 3) an increase of the spliced form of X-box binding protein 1 and increased mRNA of ER degradation-enhancing α-mannosidase-like protein, target of heterodimer of cleaved ATF6 and spliced X-box binding protein 1.
|
25978849 |
2015 |
|
Photoreceptor degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
ATF6 Is Mutated in Early Onset Photoreceptor Degeneration With Macular Involvement.
|
26070061 |
2015 |