Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory.
|
2296596 |
1990 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Diabetes increases the amount of fibronectin in retinal vessels and upregulates its expression without changing the splicing pattern of the ED-A segment.
|
8603829 |
1996 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Since the inhibition of protein kinase C (PKC) effectively blocks not only phorbol ester-induced but also high glucose- and H2O2-induced fibronectin production, the activation of PKC under diabetic conditions may also have a modulatory role in oxidative stress-induced renal injury in diabetes mellitus.
|
10588367 |
1999 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, on the collagen fibril some potentially relevant relationships between binding sites were observed including the following: fibronectin- and certain integrin-binding regions are near neighbors, which may mechanistically relate to fibronectin-dependent cell-collagen attachment; proteoglycan binding may potentially impact upon collagen fibrillogenesis, cell-collagen attachment, and collagen glycation seen in diabetes and aging; and mutations associated with osteogenesis imperfecta and other disorders show apparently nonrandom distribution patterns within both the monomer and fibril, implying that mutation positions correlate with disease phenotype.
|
11704682 |
2002 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
The results of this study indicate that glucose-induced increased FN production in diabetes may be mediated via ET-dependent NF-kappaB and AP-1 activation.
|
12388107 |
2003 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The present study was aimed at elucidating the role and mechanism of endothelins (ETs) in FN and ED-B FN expression in diabetes.
|
16741042 |
2006 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Hence, we examined the role of p300 in fibronectin expression in diabetes.
|
17065349 |
2006 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These data indicate that in diabetes increased FN production and cardiomyocyte hypertrophy may be mediated through leptin with its interaction with ET-1.
|
19391127 |
2009 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
PAI-1 deficiency did not affect plasma glucose significantly but reduced the fractional mesangial area, fibronectin and collagen I expression in the renal cortex after 20 weeks of diabetes as well as in HG-stimulated mesangial cells along with suppression of TGF-beta1 mRNA expression.
|
19786738 |
2009 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
CTD_human |
Diabetes was associated with increasing renal fibronectin and type IV collagen protein expression, with the combination regimen resulting in the highest decrease in extracellular matrix accumulation.
|
20551625 |
2010 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we investigated the role of miR-146a, an FN-targeting miRNA, on FN production in diabetes and its relationship with p300.
|
21885871 |
2011 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These findings showed that high levels of glucose in diabetes increased VEGF expression in ECs through ED-B FN and β1 integrin interaction.
|
23150625 |
2012 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
ERK5 Regulates glucose-induced increased fibronectin production in the endothelial cells and in the retina in diabetes.
|
23188731 |
2012 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Diabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin α5β1.
|
26093969 |
2015 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
These include intracellular molecules released by necrotic cells (heat shock proteins, high mobility group box 1 protein, S100 proteins), proinflammatory cytokines (interleukin-1α), specific ECM molecules up-regulated in response to tissue injury (fibronectin-EDA, tenascin-C) or molecules modified by a pathological environment (advanced glycation end product-modified proteins observed with diabetes).
|
26542796 |
2016 |
Diabetes Mellitus
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In contrast, transgenic CCR2 overexpression in the podocytes of Ccr2<sup>-/-</sup> mice resulted in significantly increased albuminuria, blood urea nitrogen, histopathologic changes, kidney fibronectin and type 1 collagen expression, podocyte loss, and glomerular apoptosis after nine weeks of streptozotocin-induced diabetes.
|
27914709 |
2017 |
Diabetes Mellitus
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Fibronectin splicing variant containing extra domain A (Fn-EDA), which is an endogenous ligand for Toll-like receptor 4 (TLR4), is present in negligible amounts in the plasma of healthy humans, but markedly elevated in patients with co-morbid conditions including diabetes and hyperlipidaemia, which are risk factors for myocardial infarction (MI).
|
29960272 |
2018 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
We investigated whether clopidogrel can reduce diabetes-induced renal fibrosis in a streptozotocin-induced type 1 diabetes murine model and fibronectin involvement in this protective response.
|
30662363 |
2019 |
Diabetes Mellitus
|
0.400 |
Biomarker
|
group |
BEFREE |
Expression of HRMs, miR-199a, miR-21, and HRMs and miR-424 and miR-210 correlated positively with HPX, fibronectin, NO, better scar formation, and tensile strength and negatively with diabetes.
|
30713578 |
2019 |