Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Insulin resistance and subclinical atherosclerosis are associated with SIRT1 downregulation in monocytes.
|
20068143 |
2010 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the effects of SIRT1 loss-of-function on the endothelium in atherosclerosis remain to be characterized.
|
20606253 |
2010 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested its association with atherosclerosis in subjects with type 2 diabetes and identified Sirtuin 1 (SirT1) as a major regulator of TIMP3 expression.
|
19581416 |
2009 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
While SIRT1 is significantly associated with atherosclerosis and diabetic complications, its relevance to coronary lesions in patients with coronary artery disease and type 2 diabetes has not been specifically investigated.
|
27123454 |
2016 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the exact mechanism by which SIRT1 prevents atherosclerosis remains largely unknown.
|
23652462 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was therefore designed to investigate the role of Sirt1 in the development of atherosclerosis.
|
23382833 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis.
|
25706717 |
2015 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on these results, SIRT1 might be a potential target for researchers aiming to develop therapeutic interventions for vascular inflammation, including atherosclerosis.
|
31023999 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, this study demonstrated that SIRT1/AMPK and Akt/eNOS signaling pathways are involved in endothelial protection of TASAES against atherosclerotic mice, suggesting that TASAES is a candidate drug for atherosclerosis treatment.
|
30637828 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sirtuin1 (Sirt1), a member of the conserved sirtuin family and a key regulator in the progression of atherosclerosis exerts protective effects by regulating autophagy, a well-known survival mechanism.
|
24378473 |
2014 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sirtuin 1 (SIRT1), a class III histone deacetylase, may protect against vascular aging and atherosclerosis; however, the effects of estrogen on SIRT1 expression and vascular smooth muscle cell (VSMC) behavior remain unknown.
|
29299128 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sirtuin 1 (Sirt1) plays an important role in vascular biology, and influences aspects of age-dependent atherosclerosis.
|
28029409 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, histone deacetylase SIRT1 has been reported to have protective effects against arterial senescence and atherosclerosis.
|
31105126 |
2020 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIRT1 is reduced in human atherosclerosis and is a critical regulator of the DNA damage response and survival in VSMCs.
|
23224247 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results had indicated that exercise training prevent the development of atherosclerosis through SIRT1 activation and oxidative stress inhibition under Hhcy situation.
|
28888894 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
BACKGROUND Sirtuin1 (SIRT1) participates in a wide variety of cellular processes, but the molecular mechanism remains largely unknown. miR-155 is an element of the inflammatory signaling pathway in atherosclerosis.
|
31752013 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
CDK5-mediated hyperphosphorylation of SIRT1 facilitates the development of endothelial senescence and atherosclerosis.
|
22753194 |
2012 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study investigated the potential association between mTOR signaling and SIRT1‑LXR‑CCR7/NF‑κB signaling (SIRT1 signaling) in AS pathogenesis.
|
28765952 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
|
29787963 |
2018 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, evolution of atherosclerosis is associated with suppression of the anti-inflammatory and anti-senescent SIRT1-HSF1-HSP molecular axis, which is refreshed by chronic heat treatment.
|
30273616 |
2019 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to investigate the potential effects of SIRT1 on AS in ApoE<sup>-/-</sup> mice and the underlying mechanisms of autophagy in an ox-LDL-stimulated human monocyte cell line, THP-1.
|
28881659 |
2017 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ablation of CaMKKβ or SIRT1 in mice with an apolipoprotein E-null background showed increased atherosclerosis both in athero-prone and in athero-protective areas.
|
23754392 |
2013 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies demonstrated further protective roles of SIRT1 in vascular biology and atherosclerosis.
|
21293192 |
2011 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resveratrol (RSV) has been regarded as potent SIRT1 activator in the treatment of atherosclerosis and cardiovascular diseases.
|
30805760 |
2019 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study indicated that miR‑92a prevented the migration of H2O2‑induced VSMCs by repressing the expression of SIRT1, and also provided a novel therapy to protect against the phenotypic change of VSMCs in atherosclerosis.
|
29115493 |
2018 |