GPR161, G protein-coupled receptor 161, 23432

N. diseases: 40; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019196
Disease: Hepatitis C
Hepatitis C 		0.010 Biomarker disease BEFREE The optimal weight to weight (w/w) ratio of streptavidin-phycoerythrin (PE) and rE2 proteins were determined for sensitive detection using HCV E2-specific hybridoma cell lines and peripheral blood mononuclear cells (PBMC) from HCV-infected individuals. 31226262 2019
CUI: C0027794
Disease: Neural Tube Defects
Neural Tube Defects 		0.010 GeneticVariation group BEFREE Our results demonstrate that GPR161 mutations cause NTDs via dysregulation of Shh and Wnt signaling in mice, and novel rare variants of GPR161 can be risk factors for SB in humans. 30256984 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 Biomarker group BEFREE In conclusion, we established rE2-ELISA that could detect horse antibodies against Getah virus after experimental and natural infections; this should be useful in the diagnosis and surveillance of Getah virus infection. 31207276 2019
CUI: C0080178
Disease: Spina Bifida
Spina Bifida 		0.010 GeneticVariation disease BEFREE Our results demonstrate that GPR161 mutations cause NTDs via dysregulation of Shh and Wnt signaling in mice, and novel rare variants of GPR161 can be risk factors for SB in humans. 30256984 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 GeneticVariation group BEFREE Moreover, earlier deletion of Gpr161 during embryogenesis increased tumor incidence and severity. 29386106 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 AlteredExpression phenotype BEFREE Gpr161 restricts GC progenitor production by preventing premature and Shh-dependent pathway activity, highlighting the importance of basal pathway suppression in tumorigenesis. 29386106 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 Biomarker disease BEFREE Knockdown of GPR161 impairs proliferation of human basal breast cancer cell lines. 24599592 2014
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 AlteredExpression phenotype BEFREE G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. 24599592 2014
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.010 Biomarker group BEFREE Consistently, GPR161 amplified breast tumors and cells overexpressing GPR161 activate mammalian target of rapamycin signaling and decrease Ile Gln motif containing GTPase Activating Protein 1 phosphorylation. 24599592 2014
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.010 Biomarker disease BEFREE Thus, we identify the orphan GPCR, GPR161, as an important regulator and a potential drug target for TNBC. 24599592 2014
CUI: C4722518
Disease: Triple-Negative Breast Carcinoma
Triple-Negative Breast Carcinoma 		0.010 Biomarker disease BEFREE Thus, we identify the orphan GPCR, GPR161, as an important regulator and a potential drug target for TNBC. 24599592 2014
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 AlteredExpression disease BEFREE The G-protein coupled receptor RE2 and phenylethanolamine N-methyltransferase had negligible expression levels in all pancreatic cancers, whereas the syntaxin 1A and p120 catenin isoform were significantly up-regulated in pancreatic cancers containing K-ras mutations compared with a pancreatic cancer with wild type K-ras gene. 13679043 2003
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 GeneticVariation disease BEFREE We identified heterozygous germline mutations in the G protein-coupled receptor 161 (<i>GPR161</i>) gene in six patients with infant-onset medulloblastoma (median age, 1.5 years). 31609649 2020
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma 		0.020 GeneticVariation disease BEFREE We identified heterozygous germline mutations in the G protein-coupled receptor 161 (<i>GPR161</i>) gene in six patients with infant-onset medulloblastoma (median age, 1.5 years). 31609649 2020
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.020 GeneticVariation disease BEFREE We identified heterozygous germline mutations in the G protein-coupled receptor 161 (<i>GPR161</i>) gene in six patients with infant-onset medulloblastoma (median age, 1.5 years). 31609649 2020
CUI: C0025149
Disease: Medulloblastoma
Medulloblastoma 		0.020 AlteredExpression disease BEFREE Low GPR161 expression correlated with poor survival of SHH subtype medulloblastoma patients. 29386106 2018
CUI: C0278510
Disease: Childhood Medulloblastoma
Childhood Medulloblastoma 		0.020 AlteredExpression disease BEFREE Low GPR161 expression correlated with poor survival of SHH subtype medulloblastoma patients. 29386106 2018
CUI: C0278876
Disease: Adult Medulloblastoma
Adult Medulloblastoma 		0.020 AlteredExpression disease BEFREE Low GPR161 expression correlated with poor survival of SHH subtype medulloblastoma patients. 29386106 2018
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0427460
Disease: Red cell distribution width determination
Red cell distribution width determination 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C1304746
Disease: RDW - Red blood cell distribution width result
RDW - Red blood cell distribution width result 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200635
Disease: Lymphocyte Count measurement
Lymphocyte Count measurement 		0.100 GeneticVariation phenotype GWASDB The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes. 22286170 2012
CUI: C0010417
Disease: Cryptorchidism
Cryptorchidism 		0.100 Biomarker disease HPO
CUI: C0011848
Disease: Diabetes Insipidus
Diabetes Insipidus 		0.100 Biomarker disease HPO
CUI: C0013336
Disease: Dwarfism
Dwarfism 		0.100 Biomarker disease HPO