|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that increase in PSMA in prostate tumors contributes to progression by altering normal signal transduction pathways to drive PCa progression and that enhanced signaling through the IGF-1R/β<sub>1</sub> integrin axis may occur in other tumors.
|
28292957 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
<sup>177</sup>Lu-DOTA-PSMA-617 (<sup>177</sup>Lu-PSMA-617) is a PSMA-targeted small molecule with favorable properties and is the most extensively investigated PSMA radioligand for radionuclide therapy (RNT) in PC.
|
31595044 |
2020 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PCR assay using PSM primers-1 showed DNA bands for 4 of 7 cases of metastatic prostate cancer and amplified the untreated genomic DNA, while that using PSM primers-2 showed 6 bands without the amplification of the genomic DNA.
|
10189895 |
1999 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
The distribution of 68Ga-PSMA avid metastatic lesions is similar to data previously reported mainly from autopsy with comparable detection rates, indicating 68Ga-PSMA PET/CT is an accurate detection tool in patients with metastatic prostate cancer.
|
30382889 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We prospectively evaluated the diagnostic performance of prostate specific membrane antigen targeted <sup>18</sup>F-DCFPyL positron emission tomography/computerized tomography in the preoperative staging of men at high risk for harboring metastatic prostate cancer despite a negative conventional staging evaluation.
|
28736318 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) PET has been recently introduced for the diagnosis of patients with metastatic prostate cancer (PCa).
|
29107272 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Utility of 68Ga-PSMA PET/CT in Poorly Differentiated Metastatic Prostate Cancer.
|
28319496 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
<sup>18</sup>F-DCFPyL is a small-molecule inhibitor of the prostate-specific membrane antigen that has shown promise for evaluation of primary and metastatic prostate cancer using PET.
|
27932557 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prospective Comparison of PET Imaging with PSMA-targeted <sup>18</sup>F-DCFPyL versus Na<sup>18</sup>F for Bone Lesion Detection in Patients with Metastatic Prostate Cancer.
|
31451492 |
2020 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), is highly overexpressed in primary and metastatic prostate cancer (PCa).
|
30656716 |
2019 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) is a receptor highly expressed on the membranes of prostate cancer (PCa) cells and provides a new opportunity for imaging and targeted therapy in metastatic prostate cancer.
|
30037209 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
The histopathology indicated metastatic prostate cancer with a Gleason score of 5 + 5 but negative for prostate-specific membrane antigen following nephroureterectomy.
|
31733274 |
2020 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the case of a 65-year-old man with castration-resistant metastatic prostate cancer who underwent Ga-PSMA ligand PET/CT for restaging of disease.
|
27997422 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination of 177Lu-PSMA-617 and External Radiotherapy for the Treatment of Cerebral Metastases in Patients With Castration-Resistant Metastatic Prostate Cancer.
|
28719450 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A biopsy was performed, and histological examination revealed multiple myeloma with PSMA expression in the neovessels but no metastatic prostate cancer cells.
|
28737577 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b><sup>68</sup>Ga-PSMA-11 performed well for the localization of metastatic prostate cancer at initial staging and at the time of biochemical recurrence.
|
30530831 |
2019 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) theranostics offers a new approach for a personalized and targeted treatment for metastatic prostate cancer.
|
29278583 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Novel imaging techniques, as multiparametric magnetic resonance imaging (MRI), whole-body MRI and Choline and prostate-specific membrane antigen (PSMA) PET imaging techniques are currently revolutioning the treatment planning in patients with advanced and metastatic PCa, allowing a better characterization of the disease.
|
29388415 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
The interference of the proinflammatory cytokine, IL-6, with bFGF signaling and PSMA, should be of high clinical relevance in the treatment of metastatic prostate cancer.
|
23250823 |
2013 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fifty-two patients with metastatic PCa who underwent [<sup>68</sup>Ga]Ga-PSMA-11 PET/CT imaging and serum prostate-specific antigen (PSA) level measurements before and during treatment were investigated.
|
31468235 |
2019 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prostate-specific membrane antigen (PSMA) PET/CT has a high diagnostic accuracy for lesion detection in metastatic prostate cancer, including bone metastases.
|
29242401 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that <sup>68</sup>Ga-PSMA-11 PET should be combined with <sup>18</sup>F-NaF PET in PC patients with skeletal metastases for restaging prior to initiation or modification of therapy.
|
29766246 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the role of Tc-MIP-1404 (Progenics Pharmaceuticals, Inc, New York, NY) SPECT/CT of PSMA expression in the assessment of treatment response in patients with metastatic prostate cancer.
|
29916921 |
2018 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tc-labeled PSMA inhibitor MIP-1404 is a promising SPECT tracer for detection of locally recurrent or metastatic prostate cancer.
|
27775936 |
2017 |
|
Metastasis from malignant tumor of prostate
|
0.100 |
Biomarker
|
disease |
BEFREE |
A total of 121 consecutive patients with recurrent PC as defined by PSMA-ligand PET (median PSA: 1.13ng/ml) underwent PSMA-targeted RGS.
|
30987843 |
2019 |