|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
|
24076602 |
2013 |
|
Narcolepsy
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association database developed in the Japanese Integrated Database Project.
|
19629137 |
2009 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Streptozotocin (STZ) was used to induce diabetes in adult DDAH1 knock-out and wild type mice.Healthy mice served as controls.
|
31818438 |
2019 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our data demonstrated that inducible nitric oxide synthase/gamma-Glutamyl-cysteine ligase (iNOS/GGCL) and DDAH dysregulation may play a key role in high glucose mediated oxidative stress, whereas HO-1 inducers such as CAPE or its more potent derivatives may be useful in diabetes and other stress-induced pathological conditions.
|
31108850 |
2019 |
|
Diabetes
|
0.030 |
Biomarker
|
disease |
BEFREE |
Innovation and Conclusion: Our results provide the first direct evidence that the DDAH1 has a marked effect on kidney fibrosis and oxidative stress induced by aging or diabetes.
|
28594240 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
From July 2006 to June 2009, we assessed the association between polymorphisms in DDAH1 and type 2 diabetes in 814 consecutive unrelated subjects, including 309 type 2 diabetic patients and 505 non-diabetic individuals.
|
21303562 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether serum ADMA levels in type 2 diabetes are influenced by common polymorphisms in the DDAH1 and DDAH2 genes.
|
20209122 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We identified that DDAH1: -396_-395insGCGT insertion allele was significantly associated with increased risk of T2DM (discovery: adjusted odds ratio [OR] = 1.380, 95% CI = 1.128-1.687, p = .002; replication: OR = 1.231, 95% CI = 1.007-1.504, p = .043).
|
31733101 |
2020 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we identified over-expression of DDAH1 in aggressive MDA-MB-231, MDA-MB-453 and BT549 breast cancer cell lines when compared to normal mammary epithelial cells.
|
29070803 |
2017 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study represents the first evidence for therapeutic inhibition of DDAH1 by small molecules in breast cancer.
|
30611984 |
2019 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
A novel loss-of-function DDAH1 promoter polymorphism is associated with increased susceptibility to thrombosis stroke and coronary heart disease.
|
20167924 |
2010 |
|
Coronary Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
|
30284143 |
2018 |
|
Coronary heart disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians.
|
30284143 |
2018 |
|
Coronary heart disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the DDAH1 loss-of-function polymorphism is associated with both increased risk of thrombosis stroke and CHD.
|
20167924 |
2010 |
|
Diabetic Nephropathy
|
0.020 |
Biomarker
|
disease |
BEFREE |
The goal of this study was to test the hypothesis that elevation of systemic ADMA levels by knocking out DDAH1 would exacerbate functional and structural glomerular abnormalities in a murine model of diabetic nephropathy.
|
31818438 |
2019 |
|
Diabetic Nephropathy
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
ADMA, SDMA and L-arginine/ADMA ratio but not DDAH genetic polymorphisms are reliable predictors of diabetic nephropathy progression as identified by competing risk analysis.
|
23147199 |
2012 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Low-dose rosuvastatin exerted cardioprotective effects on isoproterenol-induced heart failure in rats by modulating DDAH-ADMA-NO pathway, and it may present the new therapeutic value in ameliorating chronic heart failure.
|
27957828 |
2017 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we examine mechanisms of abnormal NO production in heart failure, with particular focus on the role of ADMA and DDAH1.
|
26923818 |
2016 |
|
Portal Hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our data support translational studies, targeting DDAH-1 in cirrhosis and portal hypertension.
|
25152204 |
2015 |
|
Portal Hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
This study supports a role for the DDAH1/ADMA axis on the effect of inflammation and oxidative stress in PH and provides insight for new therapies.
|
29263339 |
2017 |
|
Liver Cirrhosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
DDAH-1 immunohistochemistry was conducted on human cirrhosis and healthy liver tissue.
|
25152204 |
2015 |
|
Liver Cirrhosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
TAA-inducted liver cirrhosis was associated with significant deterioration of liver and renal functions together with increasing expression of hepatic and renal TGFβ1 and decreasing expression of hepatic and renal FXR, DDAH-1 and eNOS.
|
30308196 |
2018 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
One polymorphism (rs1498373) in the DDAH1 and three in the DDAH2 (rs805304, rs3131383, and rs805305) genes were performed by TaqMan genotyping assays in 473 patients with MI and 447 healthy unrelated controls.
|
25236572 |
2014 |
|
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In order to find new informative predictors of myocardial infarction, we performed an analysis of genotype frequencies of polymorphic markers of SELE (rs2076059, 3832T > C), SELP (rs6131, S290 N), SELL (rs1131498, rs1131498" genes_norm="6402">F206L), ICAM1 (rs5498, K469E), VCAM1 (rs3917010, c.928 + 420A > C), PECAM1 (rs668, V125L), VEGFA (rs35569394, -2549(18)I/D), CCL2 (rs1024611, -2518A > G), NOS3 (rs1799983, E298D), and DDAH1 (rs669173, c.303 + 30998A > G) genes in the group of Russian men with myocardial infarction (N = 315) and the control group of corresponding ethnicity, gender, and age (N = 286).
|
26662939 |
2016 |