|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Previously, we demonstrated that a 12-lipoxygenase (12-LOX) metabolite of arachidonic acid, 12(S)-hydroxyeicosatetraenoic acid, enhances the invasiveness of prostate cancer cells and that a 12-LOX-selective inhibitor [N-benzyl-N-hydroxy-5-phenylpentanamide] reduces experimental metastasis in animal model systems.
|
7624992 |
1995 |
|
Malignant neoplasm of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
12-LOX mRNA levels were elevated in cancer cells and the expression associated with poor differentiation and invasiveness of prostate cancer.
|
7624992 |
1995 |
|
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
12-LOX mRNA levels were elevated in cancer cells and the expression associated with poor differentiation and invasiveness of prostate cancer.
|
7624992 |
1995 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
BEFREE |
A statistically significantly greater number of cases were found to have an elevated level of 12-LOX among T3, high grade, and surgical margin-positive than T2, intermediate, and low grade, and surgical margin-negative prostatic adenocarcinomas.
|
7624992 |
1995 |
|
Glomerulonephritis
|
0.200 |
Biomarker
|
disease |
RGD |
Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
|
7967345 |
1994 |
|
Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Co-regulated expression of glomerular 12/15-lipoxygenase and interleukin-4 mRNAs in rat nephrotoxic nephritis.
|
7967345 |
1994 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
The estrogen-dependent, linoleic acid (LA)-unresponsive, MCF-7 breast cancer cell line was transfected with 12-lipoxygenase (12-LOX) cDNA (MCF-7/12-LOX cells).
|
9020925 |
1996 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The estrogen-dependent, linoleic acid (LA)-unresponsive, MCF-7 breast cancer cell line was transfected with 12-lipoxygenase (12-LOX) cDNA (MCF-7/12-LOX cells).
|
9020925 |
1996 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We studied the dependency of basal 12-lipoxygenase (12-LOX; arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31) expression and activity on functional protein tyrosine kinase of the epidermal growth factor receptor (EGF-R) and on 12-LOX activity in human A431 epidermoid carcinoma cells.
|
9174106 |
1997 |
|
Malignant neoplasm of prostate
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When we analyzed the relationship between DCC loss of expression and 12-LOX elevation in prostate cancer pati
|
9321930 |
1997 |
|
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
When we analyzed the relationship between DCC loss of expression and 12-LOX elevation in prostate cancer pati
|
9321930 |
1997 |
|
Colorectal Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that 15-Lox-1 is highly expressed in human colorectal cancer epithelial cells and that its expression may have a role in colorectal carcinogenesis.
|
9927047 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Eighteen of the 21 were found to have 15-Lox-1 in both tumor tissue and matched adjacent normal tissue, with the 15-Lox-1 expression being significantly higher in most of the tumor tissue.
|
9927047 |
1999 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that 15-Lox-1 is highly expressed in human colorectal cancer epithelial cells and that its expression may have a role in colorectal carcinogenesis.
|
9927047 |
1999 |
|
Malignant neoplasm of colon and/or rectum
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that 15-Lox-1 is highly expressed in human colorectal cancer epithelial cells and that its expression may have a role in colorectal carcinogenesis.
|
9927047 |
1999 |
|
Colorectal Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Immunohistochemical studies showed 15-Lox-1 localization in the glandular epithelium of human colorectal tumor tissue.
|
9927047 |
1999 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR results showed that human RA type B synoviocytes expressed a reticulocyte-type 15-LOX.
|
10332966 |
1999 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Comparison of the expression of 12-LOX in skin primary tumors and its lung metastases indicated a stable expression.
|
10667390 |
1999 |
|
melanoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
15% of the cell population), human melanoma lines (HT168, M1, HT199, HT18 and WM35) express the platelet-type isoform of 12-LOX both at mRNA and protein levels.
|
10667390 |
1999 |
|
Skin Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
12-LOX expression was demonstrated in cultured tumor cells and in skin tumor xenografts.
|
10667390 |
1999 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Comparison of the expression of 12-LOX in skin primary tumors and its lung metastases indicated a stable expression.
|
10667390 |
1999 |
|
Adenocarcinoma
|
0.030 |
AlteredExpression
|
group |
LHGDN |
Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging.
|
11023533 |
2000 |
|
Esophageal Neoplasms
|
0.310 |
AlteredExpression
|
group |
BEFREE |
These findings demonstrate that 15-LOX-1 is down-regulated in human esophageal carcinomas and that NSAIDs induce apoptosis in esophageal cancer cells via up-regulation of 15-LOX-1.
|
11406566 |
2001 |
|
Esophageal Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
These findings demonstrate that 15-LOX-1 is down-regulated in human esophageal carcinomas and that NSAIDs induce apoptosis in esophageal cancer cells via up-regulation of 15-LOX-1.
|
11406566 |
2001 |
|
Malignant neoplasm of esophagus
|
0.310 |
Biomarker
|
disease |
CTD_human |
These findings demonstrate that 15-LOX-1 is down-regulated in human esophageal carcinomas and that NSAIDs induce apoptosis in esophageal cancer cells via up-regulation of 15-LOX-1.
|
11406566 |
2001 |