|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results provide further insight into the role of Wnt5a and Fzd2 in the pathogenesis of ALS transgenic mice, which provides evidence that should help in the search for treatments of ALS.
|
23826406 |
2013 |
|
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overall, our results indicate that altered expression of FZD2 might be associated with a proliferative status, thus playing a role in the biology of human MBs, and possibly of cerebellar progenitors from which these malignancies arise.
|
21850537 |
2012 |
|
Congenital diaphragmatic hernia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Duplications of distal 11q and proximal 13q were found in a patient with non-isolated CDH and a de novo single gene deletion of FZD2 was identified in a patient with a partial pentalogy of Cantrell phenotype.
|
21525063 |
2011 |
|
Pentalogy of Cantrell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Duplications of distal 11q and proximal 13q were found in a patient with non-isolated CDH and a de novo single gene deletion of FZD2 was identified in a patient with a partial pentalogy of Cantrell phenotype.
|
21525063 |
2011 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Wnt1, 7b and 10b, Fzd2 and 3, beta-catenin, and Lef1 expression was significantly increased in IPF.
|
18478089 |
2008 |
|
Fibroid Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR and real-time PCR demonstrated equivalent Dlk mRNA expression between fibroid and myometrium (ratio, 1.02), a slight Frizzled-2 overexpression (ratio, 2.09), and robust CD-24 overexpression in fibroids (ratio, 12.35).
|
12909487 |
2003 |
|
Uterine Fibroids
|
0.010 |
AlteredExpression
|
group |
BEFREE |
RT-PCR and real-time PCR demonstrated equivalent Dlk mRNA expression between fibroid and myometrium (ratio, 1.02), a slight Frizzled-2 overexpression (ratio, 2.09), and robust CD-24 overexpression in fibroids (ratio, 12.35).
|
12909487 |
2003 |
|
Cortical Dysplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three genes (recombination activating gene 1 (RAG1), heat shock 60 kDa protein 1 (HSP-60), and transforming growth factor beta1 (TGF beta1)) were found to be up-regulated more than two-fold in CD, whereas four genes (phosphoinositide-3-kinase regulatory subunit polypeptide 1 [p85 alpha] (PI3K), frizzled homolog 2 [Drosophila], Bcl-2/adenovirus E1B 19 kDa interacting protein (NIP3), and glia maturation factor beta (GMF beta)) were down-regulated to less than 50% of their normal levels.
|
14643002 |
2003 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Whereas ET lines demonstrated increased expression of microtubule-associated protein tau (MAPT), protein phosphatase 1 regulatory subunit 1A (PPP1R1A), NIMA (never in mitosis gene a)-related kinase 2 (NEK2), and cyclin D1 (CCND1), neuroblastoma samples exhibited high expression of wingless-type mouse mammary tumor virus integration site family member 11 (WNT11), Drosophila frizzled homolog 2 (FZD2), and adenomatous polyposis coli (APC) which are involved in regulating free beta-catenin levels.
|
11836553 |
2002 |
|
Squamous cell carcinoma of tongue
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results indicated that FZD2 may act as an oncogene in tongue squamous cell carcinoma.
|
31595151 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Here, we provide evidence that FZD2 is a driver for EMT, cancer stem cell properties, and vasculogenic mimicry (VM) in HCC.
|
30677195 |
2019 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our data suggest for the first time that FZD2 could promote clinically relevant EMT, CD44<sup>+</sup> stem-like properties, and the VM phenotype in HCC involving a potential Hippo signaling pathway-dependent mechanism, and should be considered as a promising therapeutic target for the treatment of HCC.
|
30677195 |
2019 |
|
Secondary Neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Many studies have shown that FZD2 is significantly associated with tumor development and tumor metastasis.
|
31595151 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A significant correlation was detected between the EMT status and Fzd2 expression in the HCC patients.
|
28350091 |
2017 |
|
Secondary Neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Previous research has shown that Wnt receptor Frizzled2 (Fzd2) is elevated in many metastatic cancer cell lines and high grade tumors.
|
27373314 |
2016 |
|
Squamous cell carcinoma of tongue
|
0.020 |
Biomarker
|
disease |
BEFREE |
Using TSCCa cells (a tongue SCC cell line) for loss- or gain-of-function of Fzd2, we found that a forced overexpression of Fzd2 promoted TSCCa cell migration and invasion, decreased the expression of epithelial‑cadherin (E-cadherin, an epithelial marker) and increased that of vimentin, Snail Slug, matrix metalloproteinases (MMPs)-2/-9/-13 and a-disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS5).
|
26398330 |
2015 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis.
|
26398330 |
2015 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Here, we provide evidence that FZD2 is a driver for EMT, cancer stem cell properties, and vasculogenic mimicry (VM) in HCC.
|
30677195 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis.
|
26398330 |
2015 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Overall, our results indicate that altered expression of FZD2 might be associated with a proliferative status, thus playing a role in the biology of human MBs, and possibly of cerebellar progenitors from which these malignancies arise.
|
21850537 |
2012 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Many studies have shown that FZD2 is significantly associated with tumor development and tumor metastasis.
|
31595151 |
2019 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
However, the mechanism underlying tumor development and progression due to aberrant FZD2 expression is poorly defined.
|
30677195 |
2019 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Previous research has shown that Wnt receptor Frizzled2 (Fzd2) is elevated in many metastatic cancer cell lines and high grade tumors.
|
27373314 |
2016 |
|
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Our results suggest that FZD2 may be a tumor suppressor gene in SACCs that inhibits cell growth and migration.
|
25695658 |
2016 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
The purpose of the present study was to gain insight into the role of FZD2 in the cell proliferation and invasion of tongue squamous cell carcinoma.
|
31595151 |
2019 |