Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET The localization of the alpha3 subunit GABA receptor (GABRA3) gene in Xq28, a region of interest for BPAD suggests that GABRA3 may be a relevant candidate gene. 11602034 2001
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Recently, an association between a CA-repeat in the GABRA 3 gene and bipolar disorder had been reported. 15048654 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Moreover, the localization of the alpha3 subunit GABA receptor GABRA3 gene on the Xq28, a region of interest in certain forms of bipolar illness, suggests that GABRA3 may be a candidate gene in BPAD. 11840313 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene. 8546157 1995
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders. 2574000 1989
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Recently, an association between a CA-repeat in the GABRA 3 gene and bipolar disorder had been reported. 15048654 2004
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Lack of association between manic-depressive illness and a highly polymorphic marker from GABRA3 gene. 8546157 1995
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease BEFREE The localization of the alpha3 subunit GABA receptor (GABRA3) gene in Xq28, a region of interest for BPAD suggests that GABRA3 may be a relevant candidate gene. 11602034 2001
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease CTD_human GABA(A) receptor downregulation in brains of subjects with autism. 18821008 2009
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.300 Biomarker disease PSYGENET This work suggests that GABRA3 regulates a behavioral endophenotype of depression and establishes this gene as a viable new target for the study and treatment of human depression. 20512339 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.300 Biomarker disease PSYGENET This work suggests that GABRA3 regulates a behavioral endophenotype of depression and establishes this gene as a viable new target for the study and treatment of human depression. 20512339 2010
CUI: C0268446
Disease: Thyrotoxic periodic paralysis
Thyrotoxic periodic paralysis 		0.300 SusceptibilityMutation disease ORPHANET Association of genetic variants in GABRA3 gene and thyrotoxic hypokalaemic periodic paralysis in Thai population. 17970773 2008
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.100 Biomarker disease HPO
CUI: C0028754
Disease: Obesity
Obesity 		0.100 Biomarker disease HPO
CUI: C0034372
Disease: Quadriplegia
Quadriplegia 		0.100 Biomarker disease HPO
CUI: C0042510
Disease: Ventricular Fibrillation
Ventricular Fibrillation 		0.100 Biomarker disease HPO
CUI: C0154141
Disease: Thyrotoxicosis with toxic single thyroid nodule
Thyrotoxicosis with toxic single thyroid nodule 		0.100 Biomarker disease HPO
CUI: C0154143
Disease: Toxic multinodular goiter
Toxic multinodular goiter 		0.100 Biomarker disease HPO
CUI: C0264906
Disease: Second degree atrioventricular block
Second degree atrioventricular block 		0.100 Biomarker disease HPO
CUI: C4021553
Disease: Periodic hypokalemic paresis
Periodic hypokalemic paresis 		0.100 Biomarker disease HPO
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 AlteredExpression disease BEFREE Furthermore, GABRA3 protein expression was significantly higher in the lower grade of lung cancer. 19048400 2009
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 Biomarker disease BEFREE Here, we report identification of a novel cancer-germline transcript (CT-GABRA3) displaying DNA hypomethylation-dependent activation in various tumors, including melanoma and lung carcinoma. 25089631 2014
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.030 AlteredExpression disease BEFREE The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. 27081042 2016
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 AlteredExpression disease BEFREE The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. 27081042 2016
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 AlteredExpression disease BEFREE Furthermore, GABRA3 protein expression was significantly higher in the lower grade of lung cancer. 19048400 2009