GAD1, glutamate decarboxylase 1, 2571

N. diseases: 245; N. variants: 14
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Two scoring methods were used to convert the scores on the PHQ-9, GAD-7 and K6 to the PROMIS depression and anxiety metrics. 29872956 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Of the 336 usable responses, 16.1% scored 10 or greater on the PHQ-8 consistent with current depression while 17.3% scored 10 or greater on the GAD-7 consistent with current anxiety. 30637564 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE FMR1 gene polymorphisms, dopaminergic (DAT, DRD, COMT), serotonin (5-HTTLPR, HTR1A, HTR2A), interleukins, MCR1, HCN (potassium channel), neurorregulinas, GABAergic (GABA, GAD, DBI) DBI, GABA (Gabra) receptors and GAD genes (GAD1, GAD2) appear to contribute to generate condition of depression or anxiety like. 25106036 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE Patients with PNES had higher self-reported anxiety and depression levels (GAD-7: p = 0.04, PHQ-9: p < 0.01; BDI-II: p < 0.01) but similar QOL to PWE (p = 0.78). 31759316 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Meditation was associated with subjective benefits but no statistically significant effect on depression scores (change in PHQ-9, -3.0±3.9 in the intervention group versus -2.0±4.7 in controls; <i>P</i>=0.45) or anxiety scores (change in GAD-7, -0.9±4.6 versus -0.8±4.8; <i>P</i>=0.91). 29025788 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Primary outcome measures were assessed with the Generalized Anxiety Disorder Scale (GAD-7), Personal Health Questionnaire Depression Scale (PHQ-8), Perceived Stress Scale (PSS-14), and Pittsburgh Sleep Symptom Questionnaire-Insomnia (PSSQ-1). 29351138 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Prevalence estimates for depressive disorder (CIDI), depressive symptoms (BDI ≥ 16), anxiety symptoms (GAD-7 ≥ 10) and PTSD (PCL-C DSM criteria) were 3.8, 5.9, 3.6, and 4.5% respectively for twins and 3.9, 9.8, 5.1 and 5.4% for singletons. 29343229 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Associations between non-disclosure and the following factors were established using modified Poisson regression with adjustment for socio-demographic factors (gender, age group, ethnicity), HIV-related factors (time since HIV diagnosis, ART status), and clinic: low social support (score ≤ 12 on modified Duke-UNC FSSQ); depression and anxiety symptoms (≥10 on PHQ-9 and GAD-7 respectively); self-reported ART non-adherence in past 2 weeks/3 months; VL non-suppression (clinic-recorded VL > 50 copies/mL among those who started ART ≥ 6 months ago). 27586375 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE The response rate, as measured by a 50% decrease in scores, for those with initial scores ≥10 was 58.6% for depression (PHQ-9) and 50% for anxiety (GAD-7). 28165775 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE A binary logistic regression analyses were conducted to test the association between all four ratings in GAD-7 (anxiety) and PHQ-9 (depression) scales subitems as covariates, and migraine vs no headache as the outcome. 28324317 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females. 22662185 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE They completed the Centre for Epidemiologic Studies Depression Scale (CES-D) and the General Anxiety Disorder Scale (GAD-7) to measure whether they experience depression and/or anxiety symptoms. 29543833 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE <b>Results:</b> The study indicated that past-year Wave II financial mistreatment was associated with significantly increased likelihood of depression, PTSD, GAD, and poor self-rated health; and financial mistreatment perpetrated by family members was associated with particularly increased risk of depression. 29665715 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE The overall findings suggest that the workbook format was no less effective or acceptable than the validated online format.Significant improvements (avg. improvement; Internet Group vs Workbook Group) in levels of disability (PDI: 16% vs 24%; RMDQ: 12% vs 15%), anxiety (GAD-7: 36% vs 26%), and depression (PHQ-9: 36% vs 36%) were observed in both groups immediately posttreatment. 28394850 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE Whereas cortical GAD67 reduction and subsequent GABA level decrease are consistently observed in schizophrenia and depression, it remains unclear how these GABAergic abnormalities contribute to specific symptoms. 29362511 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Mean post treatment PHQ-9 and GAD-7 scores remained above threshold for those receiving CBT_DA but not those receiving CBT-D. 30048513 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE For GAD age at onset, family history, biology and symptomatology are close to those of depression. 18344044 2008
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Furthermore, self-rating questionnaires were used to assess somatic symptom severity (PHQ-15), depression severity (PHQ-9) and anxiety severity (GAD-7). 28554368 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 AlteredExpression disease BEFREE Self-report questionnaires were administered to assess quality of life (12-item Kansas City Cardiomyopathy Questionnaire quality of life subscale), level of anxiety (7-item Generalized Anxiety Disorder; GAD-7), level of depression (9-item Patient Health Questionnaire; PHQ-9) and device acceptance (Florida Patient Acceptance Survey; FPAS) to 101 consecutive patients presenting to LVAD clinic. 31346241 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 Biomarker disease BEFREE Item response theory-based linking methods were used to create crosswalk tables that convert scores on the GAD-7 to the TBI-QOL Anxiety metric and scores on the PHQ-9 to the TBI-QOL Depression metric. 31498233 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Primary outcomes included the Patient Health Questionnaire-9 (PHQ-9) for depression and the Generalized Anxiety Disorder-7 (GAD-7) for anxiety. 28057609 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Participants were 307 psychiatry outpatients with depression; assessed at baseline, 3-, and 6-months on symptom (PHQ-9 and GAD-7), functioning (SF-12) and past-month marijuana use for a substance use intervention trial. 28242498 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE Participants were also screened for depression using the Neurological Disorder Depression Inventory for Epilepsy (NDDI-E) and the Center for Epidemiologic Studies Depression Scale (CES-D) and for anxiety using the Generalized Anxiety Disorder-7 (GAD-7) scale. 31181426 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE PWE from rural West China were evaluated for depression and anxiety with the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E; Chinese version) and the Generalized Anxiety Disorder-7 (GAD-7; Chinese version). 30125939 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.400 GeneticVariation disease BEFREE The resulting groups were characterized with regard to Quality of Life (MacNew), anxiety and depression (GAD-7 and PHQ-9) and resilience (RS-13). 28006984 2017