Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
|
18985386 |
2009 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
This gene is closely related to GAK, identified as a possible PD susceptibility gene in the GWAS of the familial PD cases.
|
19772629 |
2009 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
|
20711177 |
2010 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
While MAPT has been considered a PD candidate gene and has been observed in association with PD in other GWAS, GAK is a new candidate for investigation in future studies.
|
21058943 |
2011 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Besides, post-hoc analysis confirmed GAK/DGKQ, HLA and MAPT as PD risk loci among the Dutch (GAK/DGKQ, rs2242235: P = 1.22 × 10(-4), OR = 1.51; HLA, rs4248166: P = 4.39 × 10(-5), OR = 1.36; and MAPT, rs3785880: P = 1.9 × 10(-3), OR = 1.19).
|
21248740 |
2011 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study.
|
21258085 |
2011 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These observations provide evidence that GAK is associated with PD risk and suggest that GAK and α-synuclein interact in a pathway involved in PD pathogenesis.
|
21258085 |
2011 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional studies of GAK to unravel its role in the pathophysiologic pathway of PD will be useful.
|
22198721 |
2012 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GAK rs1564282 and DGKQ rs11248060 increase the risk for PD in Chinese patients.
|
23618683 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The single-nucleotide polymorphism (SNP) rs1564282 of GAK gene has a significant association to the risk of PD among Caucasian populations.
|
23826309 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results supported the association between the rs11248051 variant in GAK and PD risk in a Taiwanese population.
|
24039160 |
2013 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies identified PARK16 variants rs823128 and rs947211, PARK17/GAK rs11248051 and PARK18/HLA-DRA rs3129882 as risk factors for Parkinson's disease (PD).
|
24373818 |
2014 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We used 2 PD case-control data sets (Washington University and the Parkinson's Progression Markers Initiative) to determine whether polymorphisms located at the GWAS top hits (GBA, ACMSD/TMEM163, STK39, MCCC1/LAMP3, GAK/TMEM175, SNCA, and MAPT) show association with AAO or motor progression.
|
26601739 |
2016 |
Parkinson Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Detection and interpretation of shared genetic influences on 42 human traits.
|
27182965 |
2016 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Together, these findings provide strong evidence for GAK clathrin-binding- and J-domain transcripts' influence on PD pathogenicity, and for a role for GAK in regulating synaptic function in PD.
|
27508417 |
2016 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cyclin-G-associated kinase (GAK), a PD susceptibility gene identified through genome-wide association studies (GWAS), is a ubiquitous serine/threonine kinase involved in clathrin uncoating, though its PD-related function remains elusive.
|
28147270 |
2017 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We describe recent advances on roles of kinases TAOK2, TNIK and CDKL5 in neuronal development and the converging pathways of LRRK2, PINK1 and GAK in Parkinson's Disease.
|
29241837 |
2018 |
Parkinson Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Full sequencing of TMEM175/GAK/DGKQ followed by genotyping of specific associated variants was performed in PD (n = 1,575) and rapid eye movement sleep behavior disorder (RBD) patients (n = 533) and in controls (n = 1,583).
|
31658403 |
2020 |