|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Chromosome 21 BACE2 haplotype associates with Alzheimer's disease: a two-stage study.
|
16023140 |
2005 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Common BACE2 Polymorphisms are Associated with Altered Risk for Alzheimer's Disease and CSF Amyloid Biomarkers in APOE ε4 Non-Carriers.
|
31270419 |
2019 |
|
Down Syndrome
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
|
16816112 |
2006 |
|
Complete Trisomy 21 Syndrome
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
|
16816112 |
2006 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Effects of Zn2+ binding on the structural and dynamic properties of amyloid β peptide associated with Alzheimer's disease: Asp1 or Glu11?
|
23947440 |
2013 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elucidation of the mechanism underlying BACE2 degradation is important for defining its biological features and its potential role in Alzheimer's disease drug development.
|
23773066 |
2013 |
|
Reflex Epilepsy, Audiogenic
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we detect hCoch-5B2 on three overlapping YACs, two of which also contain one of the markers linked to DFNA9. mCoch-5B2 was genetically mapped in the mouse to chromosome 12, in a region of homologous synteny with human 14q11.2-q13, which contains the asp1 (audiogenic seizure prone) locus in the mouse.
|
9441737 |
1997 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Identification of BACE2 as an avid ß-amyloid-degrading protease.
|
22986058 |
2012 |
|
Insulin C-peptide measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.
|
23903356 |
2013 |
|
Mild cognitive disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, in ε4 non-carriers diagnosed with AD or mild cognitive impairment (MCI), SNPs within the BACE2 locus are associated with cerebrospinal fluid (CSF) levels of Aβ1-42.
|
31270419 |
2019 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In particular, our system links the expression of the Alzheimer's disease hallmark gene APP (amyloid-beta precursor protein) to the beta-site-cleaving enzymes BACE and BACE2, the gamma-site-cleaving enzymes presenilin 1 and 2, apolipoprotein E, and other Alzheimer's disease-related genes.
|
15492223 |
2004 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization of biopsies from breast cancer and colon cancer patients indicated that ALP56 is upregulated in human primary tumors and liver metastasis.
|
10838186 |
2000 |
|
Malignant neoplasm of breast
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization of biopsies from breast cancer and colon cancer patients indicated that ALP56 is upregulated in human primary tumors and liver metastasis.
|
10838186 |
2000 |
|
Malignant tumor of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization of biopsies from breast cancer and colon cancer patients indicated that ALP56 is upregulated in human primary tumors and liver metastasis.
|
10838186 |
2000 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization of biopsies from breast cancer and colon cancer patients indicated that ALP56 is upregulated in human primary tumors and liver metastasis.
|
10838186 |
2000 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In situ hybridization of biopsies from breast cancer and colon cancer patients indicated that ALP56 is upregulated in human primary tumors and liver metastasis.
|
10838186 |
2000 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In situ hybridization of biopsies from breast cancer and colon cancer patients indicated that ALP56 is upregulated in human primary tumors and liver metastasis.
|
10838186 |
2000 |
|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of BACE2 or ING2 and linifanib treatment may improve the prognosis of patients with osteosarcoma.
|
30604867 |
2019 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of BACE2 or ING2 and linifanib treatment may improve the prognosis of patients with osteosarcoma.
|
30604867 |
2019 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of BACE2 or ING2 and linifanib treatment may improve the prognosis of patients with osteosarcoma.
|
30604867 |
2019 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between the polymorphisms of beta-site APP-cleaving enzyme 2 (BACE2) 5'-flanking region and sporadic Alzheimer's disease.
|
19124009 |
2009 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
DOWN SYNDROME CRITICAL REGION
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mapping to the Down syndrome critical region (chromosome 21) and identified as a homologue of BACE1, BACE2 also cleaves amyloid precursor protein at the beta-site.
|
15473697 |
2005 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistic investigations identified several interstitial genes, including Ets2 and Bace2, whose reduced expression correlated in the gene homologs in human prostate cancer with biochemical relapse and lethal disease.
|
26880803 |
2016 |