|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The differentially expressed genes (DEGs) in HCC samples were screened using the ΔΔCt method with the homogenized internal GAPDH.
|
26045814 |
2015 |
|
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we show that transcriptional activity is reduced by deletion of the nucleotides from -181 to -144 (relative to the transcriptional start site) in the promoter of human GAPDH gene, both in CHO (derived from Chinese hamster ovary) and HepG2 (derived from human hepatoma) cells.
|
9378702 |
1997 |
|
Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis.
|
15507493 |
2004 |
|
Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Preventing the increase in GAPDH-SNO abundance in both cultured neurons and mice, either by overexpression of the nitrosylation mutant of GAPDH (GAPDH C150S) or by treatment with the GAPDH nitrosylation inhibitor CGP3466B (also known as omigapil), abrogated Aβ<sub>1-42</sub>-induced tau acetylation, memory impairment, and locomotor dysfunction in mice, suggesting that this drug might be repurposed to treat patients with AD.
|
29559585 |
2018 |
|
Alzheimer's Disease
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
When the two family datasets were examined, none of the SNPs were significant in NE families, but two SNPs were associated with AD in Caribbean Hispanics: rs740850 in NCAPD2 (p = 0.0097) and rs1060620 in GAPDH (p = 0.042).
|
18340469 |
2008 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The copy number of Ki-67 mRNA correlated with copy numbers of GAPDH mRNA in all fractions of cirRNA of healthy donors and breast cancer patients.
|
17108228 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A FAM labeled MGB probe and primers were used to amplify the mtDNA sequence of the ATP 8 gene, and a VIC labeled MGB probe and primers were employed to amplify the glyceraldehyde-3-phosphate-dehydrogenase gene. mtDNA content was correlated with tumor stage, menstruation status, and age of patients as well as lymph node status and the expression of estrogen receptor (ER), progesterone receptor (PR) and Her-2/neu protein.
|
20025731 |
2009 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The (A)10 repeat in the promoter region (position -178 to approximately -169) of the GAPDH gene was altered in 17% of the tumors.
|
11526511 |
2001 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs1136666 polymorphism of GAPDH was determined to be closely associated with PD.
|
29886133 |
2018 |
|
Parkinson Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the first study of genetic association between GAPDH locus and risk for PD in the Chinese population.
|
26258539 |
2015 |
|
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The copy number of Ki-67 mRNA correlated with copy numbers of GAPDH mRNA in all fractions of cirRNA of healthy donors and breast cancer patients.
|
17108228 |
2006 |
|
Secondary malignant neoplasm of lymph node
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In the diffuse type of gastric cancer, the High-HOTAIR group (HOTAIR/GAPDH > 1) showed significantly more venous invasion, frequent lymph node metastases and a lower overall survival rate compared to the Low-HOTAIR group (HOTAIR/GAPDH < 1).
|
24130837 |
2013 |
|
Tumor Cell Invasion
|
0.050 |
GeneticVariation
|
phenotype |
BEFREE |
In the diffuse type of gastric cancer, the High-HOTAIR group (HOTAIR/GAPDH > 1) showed significantly more venous invasion, frequent lymph node metastases and a lower overall survival rate compared to the Low-HOTAIR group (HOTAIR/GAPDH < 1).
|
24130837 |
2013 |
|
Squamous cell carcinoma of esophagus
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
After excluding genes with previous GWAS signals, candidate pathways (and genes) for ESCC risk included taste transduction (KEGG_hsa04742; TAS2R13, TAS2R42, TAS2R14, TAS2R46,TAS2R50), long-patch base excision repair (Reactome_pid; POLD2) and the metabolics pathway (KEGG_hsa01100; MTAP, GAPDH, DCTD, POLD2, AMDHD1).
|
26635288 |
2016 |
|
Alzheimer Disease, Late Onset
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.
|
15507493 |
2004 |
|
Liver neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Here we show that transcriptional activity is reduced by deletion of the nucleotides from -181 to -144 (relative to the transcriptional start site) in the promoter of human GAPDH gene, both in CHO (derived from Chinese hamster ovary) and HepG2 (derived from human hepatoma) cells.
|
9378702 |
1997 |
|
Asthenozoospermia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
For this reason, we investigated the glyceraldehyde 3-phosphate dehydrogenase gene in human sperm to evaluate whether asthenozoospermia was correlated with any changes in its expression.
|
27080476 |
2018 |
|
ACTH-Secreting Pituitary Adenoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Of the 34 pituitary adenomas studied, Ptx-1 expression was reduced by more than 50% compared to that of the housekeeping gene human glyceraldehyde-3-phosphate dehydrogenase in the 6 corticotroph adenomas, which also had significantly reduced alpha-subunit production (all 6 tumors secreting < or =0.5 ng/24 h).
|
10902805 |
2000 |
|
Hemochromatosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Duodenal biopsy samples were analyzed using real-time PCR for expression of DMT1, FPN1, DCYTB, and HEPH relative to GAPDH from 23 C282Y homozygotes, including 5 "nonexpressors" (serum ferritin < upper limit of normal and absence of phenotypic features of hemochromatosis) and 18 "expressors."
|
19892936 |
2010 |
|
Scrub Typhus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
For relative quantification of O. tsutsugamushi bacteria per volume of whole blood, we performed real-time DNA PCR analysis of the human GAPDH gene, along with the O. tsutsugamushi 47-kDa gene.
|
21068287 |
2011 |
|
Thyroid Neoplasm
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
These data indicate that nitric oxide-mediated S-nitrosylation of GAPDH and subsequent nuclear translocation of GAPDH might function as a mediator of TRAIL-induced cell death in thyroid cancer cells.
|
17540725 |
2007 |
|
HEMOCHROMATOSIS, TYPE 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Duodenal biopsy samples were analyzed using real-time PCR for expression of DMT1, FPN1, DCYTB, and HEPH relative to GAPDH from 23 C282Y homozygotes, including 5 "nonexpressors" (serum ferritin < upper limit of normal and absence of phenotypic features of hemochromatosis) and 18 "expressors."
|
19892936 |
2010 |
|
Sporadic Parkinson disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.
|
26258539 |
2015 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The involvement of GAPDH in several hepatocarcinogenic mechanisms (e.g. viral hepatitis, metabolic alterations) and its sensitivity to a new class of prospective anticancer agents prompted us to review the current understanding of the therapeutic potential of targeting GAPDH in HCC.
|
22964488 |
2012 |
|
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS.
|
21472284 |
2012 |