Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021400
Disease: Influenza
Influenza
0.020 Biomarker disease BEFREE Previous studies indicated that Actinobacillus pleuropneumoniae PalA is homologous to a Haemophilus influenzae protective antigen Hi-PAL (P6) protein. 28828973 2017
CUI: C0021400
Disease: Influenza
Influenza
0.020 Biomarker disease BEFREE Moreover, the sequence had a high degree of similarity to the peptidoglycan-associated outer membrane lipoprotein P6 of Haemophilus influenzae and the peptidoglycan-associated lipoprotein PAL of E. coli. 8576327 1995
CUI: C0002170
Disease: Alopecia
Alopecia
0.010 Biomarker disease BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
CUI: C0003123
Disease: Anorexia
Anorexia
0.010 Biomarker disease BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
CUI: C0015672
Disease: Fatigue
Fatigue
0.010 Biomarker phenotype BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
CUI: C0027497
Disease: Nausea
Nausea
0.010 Biomarker phenotype BEFREE Analysis of the QLQ-C15-PAL and BN20 scales revealed significant deterioration in patients treated with WBRT and SRT in physical function (p < 0.001 and p = 0.007), fatigue (p < 0.001 and p = 0.036), nausea (p = 0.003 and p = 0.002), appetite loss (p < 0.001 and p = 0.025), drowsiness (p < 0.001 and p = 0.011), hair loss (p = 0.019 and p = 0.023) and itchy skin (p = 0.030 and p = 0.018). 31418046 2020
CUI: C3496069
Disease: cocaine use
cocaine use
0.010 Biomarker disease BEFREE 3-Fluoroamphetamine (also called PAL-353) is a synthetic amphetamine analog that has been investigated for cocaine use disorder (CUD), yet no studies have characterized its pharmacokinetics (PK). 31642004 2020
CUI: C0017574
Disease: Gingivitis
Gingivitis
0.010 Biomarker disease BEFREE PAL-V achieved by regenerative therapy in infrabony defects is as stable over 5 years as periodontally reduced but gingivally healthy or gingivitis sites. 30972774 2019
CUI: C0040820
Disease: Trematode Infections
Trematode Infections
0.010 Biomarker group BEFREE Although sensitive to distomatosis, γGT and PAL values were inconsistent with the infection rate. 30689191 2019
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders
0.010 AlteredExpression group BEFREE The comparison of TGY vs. BS revealed eight up-regulated genes (PAL, C4H, CHS, F3'H, F3H, DFR, ANS, and ANR) and two down-regulated genes (FLS and CCR) in flavonoid metabolism, four up-regulated genes (AMPD, IMPDH, SAMS, and 5'-Nase) and one down-regulated XDH gene in caffeine metabolism; and two down-regulated genes (ALDH and HIBADH) in limonene degradation. 30943892 2019
CUI: C0376154
Disease: Skin callus
Skin callus
0.010 AlteredExpression disease BEFREE Phytochemical analysis of the callus cultures showed higher production of phenolics (TPC:3.0 mg), flavonoids (TFC:1.8 mg), phenylalanine ammonialyase activity (PAL: 5.8 U/mg) and antioxidant activity (90%), respectively, in the callus cultures established on MS media in the presence of 90 ug/l AgNPs. 30856344 2019
CUI: C0748073
Disease: psychosocial stressor
psychosocial stressor
0.010 GeneticVariation disease BEFREE PA data were collected with the accelerometer ActiGraph GT3X (Pensacola, FL, USA), SED data with the inclinometer activPAL (PAL Technologies Ltd., Glasgow, Scotland, UK), and psychosocial stressors with a web questionnaire. 31547253 2019
CUI: C1145670
Disease: Respiratory Failure
Respiratory Failure
0.010 Biomarker disease BEFREE In conclusion, the current P-PAL design met our pumping, oxygenation, and hemolysis specifications and has the potential to improve treatment for pediatric respiratory failure. 29240630 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.010 AlteredExpression disease BEFREE NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2).AMT was assessed at T0 and T1. 29763431 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.010 AlteredExpression disease BEFREE NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2).AMT was assessed at T0 and T1. 29763431 2018
CUI: C0011847
Disease: Diabetes
Diabetes
0.010 Biomarker disease BEFREE The PAL project develops a conversational agent with a physical (robot) and virtual (avatar) embodiment to support diabetes self-management of children ubiquitously. 29548599 2018
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.010 Biomarker group BEFREE The PAL project develops a conversational agent with a physical (robot) and virtual (avatar) embodiment to support diabetes self-management of children ubiquitously. 29548599 2018
CUI: C0233488
Disease: Feeling despair
Feeling despair
0.010 GeneticVariation phenotype BEFREE Outcome measures were ego-integrity and despair (NEIS), psychological distress, anxiety and depression (HADS), quality of life (EORTC QLQ-C15-PAL), and specificity of the autobiographical memory (AMT). 29763431 2018
CUI: C0344315
Disease: Depressed mood
Depressed mood
0.010 AlteredExpression phenotype BEFREE NEIS, HADS and EORTC QLQ-C15-PAL were assessed at baseline (T0), 1 month later (post-treatment; T1), and at 1 month follow-up (T2).AMT was assessed at T0 and T1. 29763431 2018
CUI: C0457949
Disease: Chronic low back pain
Chronic low back pain
0.010 Biomarker disease BEFREE The PAL-S has demonstrated content validity and is potentially useful to assess treatment benefit in cLBP clinical trials. 29432327 2018
Secondary malignant neoplasm of liver
0.010 Biomarker disease BEFREE Prospective QoL was measured using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires, Core 15 for Palliative Care (EORTC QLQ-C15-PAL) and liver metastases (LM21), at baseline, 1st week and last day of treatment, then 1, 6 and 12 weeks after SABR. 30274721 2018
CUI: C0751434
Disease: Classical phenylketonuria
Classical phenylketonuria
0.010 Biomarker disease BEFREE Long-term safety and efficacy of pegvaliase for the treatment of phenylketonuria in adults: combined phase 2 outcomes through PAL-003 extension study. 29973227 2018
CUI: C3890602
Disease: Bodily Pain
Bodily Pain
0.010 Biomarker phenotype BEFREE Convergent validity was demonstrated with PAL-I total score and Roland-Morris Disability Questionnaire (Pearson correlation 0.82), MOS-36 Physical Functioning (-0.71), and MOS-36 Bodily Pain (-0.71). 29889120 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.010 Biomarker disease BEFREE A lectin with strong cytotoxic effect on human colon cancer HT29 and monkey kidney VERO cells was recently identified from the Australian indigenous mushroom Psathyrella asperospora and named PAL. 28168856 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.010 Biomarker disease BEFREE We retrospectively compared 33 consecutive cases treated with 18-mm-diameter stents (bridge to surgery [BTS] in 25, palliative therapy [PAL] in 8) with 27 consecutive cases treated with 22-mm-diameter stents (BTS in 21, PAL in 6) for obstructive colorectal cancer between May 2013 and November 2015 in our institution. 29258112 2017