Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 allelic variant.
|
22105996 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This significant haplotype distribution difference suggests that polymorphisms in the PTPN22 gene other than R620W are involved in either predisposition to or protection from T1D in the Japanese population.
|
20510318 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A functional single nucleotide polymorphism, 1858C>T, in the PTPN22 gene, encoding a tyrosine phosphatase, has been reported to be associated with type I diabetes and some other autoimmune diseases.
|
15759012 |
2005 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A recent study of T1D cases and controls provided evidence for association between an allele of a functional single-nucleotide polymorphism (SNP) in the PTPN22 gene and T1D.
|
15526003 |
2004 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Pancreatic autoantibodies, HLA DR and PTPN22 polymorphisms in first degree relatives of patients with type 1 diabetes and multiethnic background.
|
22068554 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis of TDT confirms that the PTPN22 C1858T polymorphism is associated with T1D susceptibility in Europeans.
|
23054006 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The protein tyrosine phosphatase LYP, a key regulator of TCR signaling, presents a single nucleotide polymorphism, C1858T, associated with several autoimmune diseases such as type I diabetes, rheumatoid arthritis, and lupus.
|
23359562 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we show that T1D risk alleles residing at the PTPN22, IL27, IL18RAP and IL10 loci protect against CD.
|
20176734 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A single-nucleotide polymorphism in the PTPN22 gene encoding the lymphoid protein tyrosine phosphatase (Lyp) has recently been identified as a functional variant associated with susceptibility to rheumatoid arthritis (RA), type 1 diabetes, and systemic lupus erythematosus.
|
15986374 |
2005 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The PTPN22 1858T allele but not variants in the proximal promoter region of IL-21 gene is associated with the susceptibility to type 1 diabetes and the presence of autoantibodies in a Brazilian cohort.
|
23480181 |
2013 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A variant (R620W) of PTPN22 was associated with type 1 diabetes and other autoimmune diseases in Caucasians, but the variant was absent in Asians.
|
17452059 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This is the first report demonstrating enhanced T1D in a mouse modeling human PTPN22(R620W) and the utility of CRISPR-Cas9 for direct genetic alternation of NOD mice.
|
27207523 |
2016 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Type 1 diabetes mellitus. Comparison between the association with PTPN22 genotype and the association with ACP1-ADA1 joint genotype.
|
25125338 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism, rs1217419, located in the second intron of the PTPN22 gene was associated with Type 1 diabetes (odds ratio 1.5, 95% CI 1.14-1.97, P = 0.003).
|
24117662 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Children of parents with type 1 diabetes and prospectively followed from birth for the development of islet autoantibodies and diabetes were genotyped for single-nucleotide polymorphisms at 12 type 1 diabetes susceptibility genes (ERBB3, PTPN2, IFIH1, PTPN22, KIAA0350, CD25, CTLA4, SH2B3, IL2, IL18RAP, IL10 and COBL).
|
22932816 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
A significant association was detected between the variant genotype of the PTPN22 gene (C1858T, rs2476601) and T1DM in Kuwaiti Arabs.
|
29924845 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Given the modest odds ratios of known risk alleles for inflammatory diseases, these analyses do not exclude a role for the PTPN22 allele in susceptibility to CD or MS, but they do suggest that such a putative role would probably be more modest than that reported so far in T1D, RA, SLE, and AIT.
|
16391555 |
2006 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis.
|
20445565 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The PTPN22 T1858 allele appeared significantly increased in T1DM compared to the control group (P=0.004), yielding an OR of 1.73 (95% CI 1.19-2.51).
|
20518841 |
2010 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
|
17632545 |
2007 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The PTPN22 1858T allele was strongly associated with progression to T1D after the appearance of the first biochemically defined β-cell autoantibody (hazard ratio 1.68 [95% CI 1.09-2.60], P = 0.02 Cox regression analysis, multivariate test), and the effect remained similar when analyzed after the appearance of the second autoantibody (P = 0.013), whereas INS-23 HphI AA genotype was not associated with progression to clinical diabetes after the appearance of the first or second autoantibody (P = 0.38 and P = 0.88, respectively).
|
22357962 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The objective was to assess whether the relative risk for type 1 diabetes conferred by established susceptibility loci human leukocyte antigen (HLA)-DQ, INS, and PTPN22 differed depending on these perinatal factors.
|
21352425 |
2011 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that genetic polymorphisms in the PTPN22 gene may increase the risk of T1DM in Chinese children and adolescents.
|
25729936 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The PTPN22 1858T gene variant in type 1 diabetes is associated with reduced residual beta-cell function and worse metabolic control.
|
18252906 |
2008 |
Diabetes Mellitus, Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We conclude that PTPN22 1858T allele is an independent risk factor for type 1 diabetes and associated with younger age at the onset of the disease.
|
20438787 |
2010 |