|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to examine the expression of GATA-3 mRNA and its colocalization within the airways of asthmatic and nonasthmatic individuals.
|
9949310 |
1999 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate here that peroxisome proliferator-activated receptors (PPARs), PPAR-alpha and PPAR-gamma, which have been shown recently to be involved in the regulation of various cell types within the immune system, decrease antigen-induced airway hyperresponsiveness, lung inflammation, eosinophilia, cytokine production, and GATA-3 expression as well as serum levels of antigen-specific IgE in a murine model of human asthma.
|
12900517 |
2003 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The expression level of GATA-3 may not be an essential factor to cause IL-5 hyperproduction in bronchial asthma, though GATA-3 is crucially involved in IL-5 gene transcription in human peripheral CD4+ T cells.
|
15947486 |
2005 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a haplotype analysis of GATA3 showed 3 related haplotypes that associated with different asthma and atopy related phenotypes among both the family and case-control data sets.
|
15637551 |
2005 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In bronchial biopsies, the basal expression of GATA-3 was increased in asthmatics compared to healthy controls but decreased after allergen challenge.
|
16498264 |
2006 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We report using p62-/- mice and cells that p62 acts downstream TCR activation, and is important for Th2 polarization and asthma, playing a significant role in the control of the sustained activation of NF-kappaB and late synthesis of GATA3 and IL-4 by participating in the activation of the IKK complex.
|
16874300 |
2006 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Potential anti-mRNA drugs in asthma and other allergic disorders may be targeted to cell surface receptors (adenosine A1 receptor, high-affinity receptor Fc-epsilon RI-alpha, cytokine receptors), adhesion molecules and ligands (ICAM-1, VLA-4), ion channels (calcium-dependent chloride channel-1), cytokines and related factors (IL-4, IL-5, IL-13, SCF, TNF-alpha, TGF-beta1), intracellular signal transduction molecules, such as tyrosine-protein kinases (Syk, Lyn, Btk), serine/ threonine-protein kinases (p38 alpha MAPkinase, Raf-1), non-kinase signaling proteins (RasGRP4), and transcription factors involved in Th2 differentiation and allergic inflammation (STAT-6, GATA-3, NF-kappaB).
|
16364194 |
2006 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
RGD |
Intraperitoneal ligustrazine administration could significantly lower the level of IL-4 in BALF and the expression of GATA-3 protein in lung and also increase the level of IFN-gamma and T-bet in asthmatic rats, resulting in a decreased percentage of eosinophils (EOS) in BALF and ameliorated airway inflammatory cell infiltration.
|
18186587 |
2007 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified T cell transcription factors important for asthma - such as T-bet, c-maf, GATA-3.
|
18537589 |
2008 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We studied the silencing of the GATA-3 gene expression using RNA interference (RNAi) delivered by a lentiviral vector, to evaluate the therapeutic role of GATA-3 short hairpin RNAs (shRNAs) in a murine model of asthma.
|
17878900 |
2008 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Major transcription factors controlling T(H)1 and T(H)2 development, such as T-box transcription factor and GATA3, might be centrally involved in asthma and atopic diseases.
|
19038437 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
GATA binding protein 3 (GATA3) is a key molecule regulating the balance in the ratio of type 1 helper T (Th1) cells to type 2 helper T (Th2) cells, which is thought to be indicative of the pathogenesis of allergic diseases such as asthma and atopic dermatitis.
|
21537830 |
2011 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Biopsy specimens from CRS patients without asthma were subjected to immunohistochemistry for detection of T-bet and GATA-3 expression in CD3+ T cells by double labeling.
|
24153332 |
2013 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, the percent of Th2 cells, IL-4 levels and expression of GATA-3 mRNA was markedly higher in patients with mild and moderate to severe asthma than in the control group.
|
23786933 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous studies have proved that ligustrazine can modulate the expression of transcription factors for Th1 (T-bet) and Th2 (Gata-3) in asthma.
|
24785327 |
2014 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review we will try to explore the link between IL-13 and GATA3 in the progression and regulation of asthma and its possible role as a therapeutic target.
|
24363163 |
2014 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results of the present study suggested that the therapeutic mechanism by which afzelin effectively treats asthma is based on reduction of Th2 cytokine via inhibition of GATA-binding protein 3 transcription factor, which is the master regulator of Th2 cytokine differentiation and production.
|
25738969 |
2015 |
|
Asthma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, we demonstrated that the GATA3 CpG loci associated with later risk of asthma lie within a NF-κB binding site and that methylation here blocks transcription factor binding to the GATA3 promoter in the human Jurkat T-cell line.
|
28756630 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
STAT-6 and GATA-3 are reported to be central players in PARP-1-mediated eosinophilic inflammation in asthma.
|
28974953 |
2017 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we summarize the development of a GATA-3-specific DNAzyme-a molecule class that combines the superior specificity of antisense molecules with an inherent RNA-cleaving enzymatic activity-for the treatment of type-2-driven asthma from preclinical development toward a proof-of-concept clinical study.
|
27910098 |
2017 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, IL-17A/IL-10 and RORγt/Foxp3 ratios, but not IL-4/IFN-γ or GATA-3/T-bet ratios, negatively correlated with forced expiratory volume in the first second (FEV<sub>1</sub>)/FEV<sub>1pred</sub> and Asthma Control Test Questionnaire (ACT) scores in both exacerbation group and non-exacerbation group.
|
30233198 |
2018 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Airway hyperreactivity, leukocyte infiltration, tissue remodeling, and cytokine levels as well as phosphorylated GC receptor (p-GCR), p-GATA-3, p-p38, MAPK phosphatase-1 (MKP-1), and GC-induced leucine zipper (GILZ) levels were assessed.
|
29914889 |
2018 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
With the exception of CD19+ cells and IL‑12p40, M. atichisonii affected almost all factors related to asthma induction including the T helper (Th)1/Th2 transcription factors, T‑bet and GATA‑3, Th1‑related cytokines, Th2‑related cytokines and proinflammatory cytokines.
|
29115454 |
2018 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Further, low-dose LPS (1 ug) exposure was associated with increased Th1 cytokines, T-bet, Treg cytokine (IL-10, TGF-β), and Foxp3 expression, but decreased Th2 cytokines (IL-4,5,13), GATA3, Th17, and ROR-gt expression compared with the asthma group.
|
29768397 |
2018 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
DFSCs decreased IL-4 and GATA3 expression and increased IFN-γ, T-bet and IL-10 expression in asthmatics.
|
29498435 |
2018 |