|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, we conclude that FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.
|
15902306 |
2005 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes.
|
22442730 |
2012 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate the association of 3' untranslated region (UTR) single-nucleotide polymorphisms (SNPs) in the FGF-21 gene with MetS, obesity, and diabetes in the Han Chinese population.
|
21988350 |
2012 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The unexpected finding of an antibody that can activate FGF21-like signaling through cell surface receptors provided preclinical validation for an innovative therapeutic approach to diabetes and obesity.
|
23197570 |
2012 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recent results suggest that FGF21 is highly expressed in hepatocytes under metabolic stress caused by starvation, hepatosteatosis, obesity and diabetes.
|
23590285 |
2013 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that systemic administration of liraglutide induces hepatic Fgf21 production and suppresses the social isolation-induced obesity and diabetes independently of insulin, glucagon, and active GLP-1 in KKA(y) mice.
|
24804243 |
2014 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Fibroblast growth factors 19 and 21 (FGF19 and FGF21) have been implicated, independently, in type 2 diabetes (T2D) but it is not known if their circulating levels correlate with each other or whether the associated hepatic signaling mechanisms that play a role in glucose metabolism are dysregulated in diabetes.
|
25664662 |
2015 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor 21 (FGF21), liver-derived hormone, exerts diverse metabolic effects, being considered for clinical application to treat obesity and diabetes.
|
28374855 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association of serum FGF21 with subclinical stages of diabetic nephropathy may unearth perspectives on early detection and prevention of the advanced stages of chronic diabetes microvascular complications through effective FGF21-targeted therapy.
|
28181108 |
2017 |
|
Diabetes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is in contrast to the anti-diabetic medication metformin and suggests that the treatment of obesity and diabetes with the combination of FGF21 and AMPK activators merits consideration.
|
28580278 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have reported that FGF21 is expected to become a new drug for treatment of diabetes.
|
28143735 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we prospectively evaluated the sex-specific association between FGF-21 and diabetes in a Chinese population.
|
29021814 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
FGF21 had the best change in log likelihood when added to a diabetes prediction model (DP) based on age, family history, smoking, hypertension, BMI, dyslipidaemia and FG.
|
27611701 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
FGF21 prevents the onset of diet-induced diabetes, without changing body fat mass.
|
28770320 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Associations of fibroblast growth factor 21 with cardiovascular risk and β-cell function in patients who had no history of diabetes.
|
28735064 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Brown adipose tissue (BAT)-dependent thermogenesis and its suggested augmenting hormone, FGF21, are potential therapeutic targets in current obesity and diabetes research.
|
28768181 |
2017 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Muscle transcriptome analysis revealed the induction of mitochondrial biogenesis, down-regulation of diabetes-related genes, and increased expression of the genes encoding the myokines FGF21 and GDF15.
|
28223503 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibroblast growth factor 21 (FGF21) is a major metabolic regulator that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome, but few studies about the relationship between serum FGF21 and the complications of diabetes have been done.
|
29285020 |
2017 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes.
|
29603632 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Circulating FGF21 level was independently associated with CIN (aOR: 4.66, 95% CI: 1.29-16.86, p = 0.019) and renal function decline (aHR: 7.98, 95% CI: 4.07-15.66, p < 0.001) whether diabetes was present or not.
|
30127382 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
During the past decade, there has been an enormous effort made to understand the physiological roles of FGF21 in regulating metabolism and to identify the mechanism for its potent pharmacological effects to reverse diabetes and obesity.
|
29727594 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection.
|
29634312 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Numerous studies have been conducted to establish and confirm whether FGF21 exerts beneficial effects on obesity and diabetes along with its complications.
|
29989062 |
2018 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed whether plasma concentrations of three known myokines [myonectin, myostatin, and fibroblast-derived growth factor 21 (FGF-21)] would be associated with direct and indirect indicators of insulin resistance (IR) in individuals who did not have a diagnosis of diabetes.
|
29445355 |
2018 |
|
Diabetes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, in contrast to what is observed in obesity and diabetes, high levels of FGF21 in healthy aging are not associated with repressed FGF21-responsiveness machinery in adipose tissue.
|
30043445 |
2018 |