|
Steatohepatitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
With consumption of HFHS diet, FGF21 deficient mice (FGF21 KO) develop excess fatty liver within 16 weeks.
|
29753678 |
2018 |
|
Steatohepatitis
|
0.400 |
Therapeutic
|
disease |
CTD_human |
SIRT1-mediated activation of FGF21 prevents liver steatosis caused by fasting.
|
24184811 |
2014 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> FGF-21 levels were significantly higher in subjects with high-grade liver steatosis (<i>P</i> < 0.001).
|
31750276 |
2019 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Chronic treatment with recombinant FGF21 reduces serum and hepatic triglyceride levels and ameliorates fatty liver in obese mice, through the suppression of the lipogenic gene, Srebp-1.
|
28337713 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In human liver tissues, FGF21 mRNA expression increased with the degree of steatosis.
|
20675007 |
2010 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There was a tendency towards higher levels of hepatic FGF21 mRNA in patients with lobular inflammation and fibrosis and towards lower levels in the case of hepatocyte ballooning and steatosis.
|
28820393 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Importantly, estrogen replacement restored hepatic FGF21 levels and reduced hepatic steatosis in HFFD-fed OVX rats.
|
28559436 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Forced FGF21 expression in partial hepatectomized hPPARα(PAC) reduced hepatic steatosis, prevented focal necrosis, and restored liver mass.
|
25991671 |
2015 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
FGF21 decreases in association with reductions in liver fat, GGT, and FIB4, suggesting that FGF21 is upregulated in the context of steatosis and steatohepatitis and is reduced when these conditions improve.
|
29031905 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both hepatic PCK1 and plasma FGF21 correlated strongly and inversely with hepatic TG content, suggesting a key role for PCK1 and increased gluconeogenesis in resolving steatosis with a high-protein diet, with FGF21 expression reflecting declining cell stress.
|
28457799 |
2017 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
PsTag600-FGF21 dose-dependently reduced body weight, blood glucose, and insulin and lipid levels and reversed hepatic steatosis.
|
29859019 |
2018 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Collectively, the results of the present study revealed a new mechanism underlying the regulation of hepatic ER stress and FGF21 expression induced by EPO; thus, EPO may be considered as a potential therapeutic agent for the treatment of fatty liver and obesity.
|
31173165 |
2019 |
|
Steatohepatitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Their body weight, glucose-lipid metabolism, inflammation indices, hepatic steatosis and fibroblast growth factor 21 (FGF21) levels were measured.
|
30355361 |
2018 |