Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The family members of the patients affected with GCK mutation were also examined.Two of the 58 PTDM patients (3.4%) were found to have GCK mutations.
|
11106831 |
2000 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Unusual causes of diabetes have been identified, including autosomal dominant, single gene forms due to mutations of glucokinase, the hepatocyte nuclear factors, and insulin promoter factor 1.
|
11467342 |
2000 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Unlike in MODY2, which is a nonprogressive form of diabetes, mitochondrial diabetes does show a pronounced age-dependent deterioration of pancreatic function indicating involvement of additional processes.
|
14749274 |
2004 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our cohort included 46 diabetic HNF1A gene mutation carriers, 55 type 2 diabetes (T2DM) subjects, 42 type 1 diabetes (T1DM) patients, and 31 glucokinase (GCK) gene mutation carriers with diabetes as well as 51 healthy controls.
|
25987348 |
2015 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
DNA was isolated from lymphocytes, and DNA polymorphisms in the glucokinase gene were tested for linkage with diabetes.
|
8433729 |
1993 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The glucokinase and mitochondrial tRNA(Leu(UUR)) genes were screened for mutations in at least one affected subject from each family in order to assess the contribution of mutations in these genes to the development of the diabetes.
|
7542040 |
1995 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Molecular analysis by PCR sequencing of the promoter, the 5' untranslated region (UTR) and exons of both GCK and HNF1A genes was carried out in two families with clinically diagnosed dominant diabetes mellitus.
|
23009393 |
2013 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Biochemical genetic studies have characterized many activating and inactivating GK mutants that have been discovered in patients with hyperinsulinemic hypoglycemia or diabetes, all inherited as autosomal dominant traits.
|
12475782 |
2002 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Variation at the rs560887 locus of G6PC2 is associated with worse glycated haemoglobin levels in individuals with GCK mutations; GG homozygotes are more likely to meet diagnostic criteria for diabetes based on HbA(1c) level.
|
22486180 |
2012 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
|
8325892 |
1993 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In the absence of a crystal structure for glucokinase, our models help rationalize the potential effects of mutations in diabetes and hypoglycemia, and the models may also facilitate the discovery of pharmacological glucokinase activators and inhibitors.
|
10480597 |
1999 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We aimed to derive age-related HbA1c reference ranges for these patients to determine how well HbA1c can discriminate patients with a GCK mutation from unaffected family members and young-onset type 1 (T1D) and type 2 diabetes (T2D) and to investigate the proportion of GCK mutation carriers diagnosed with diabetes using HbA1c and/or FPG diagnostic criteria.
|
23799006 |
2013 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
LHGDN |
Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy.
|
18571549 |
2008 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
GCK-MODY carriers were found in a frequency of 3% among 1043 diabetes mellitus (DM) patients and constituted the second most numerous group of DM patients, following type 1 DM, in our centre.
|
28663157 |
2017 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Over a three-year period, 72 pregnant women with recently diagnosed diabetes mellitus were prospectively assessed for presence of the most common pathogenic GCK mutations.
|
25012807 |
2015 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Clinical characteristics of mutation carriers in a large family with glucokinase diabetes (MODY2).
|
16026363 |
2005 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
MODY due to mutations in the glucokinase gene is a relatively mild form of diabetes with mild fasting hyperglycemia and IGT in the majority.
|
8035658 |
1994 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Cases of diabetes that are caused by GCK mutations may not be as rare in Japanese subjects as previously described and could be found in patients tentatively diagnosed as type 2 diabetes.
|
21720051 |
2011 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Clinical characteristics in the subjects with glucokinase gene mutations are similar to those in Caucasian subjects; diabetes mellitus is generally mild and some patients actually remain as having impaired glucose tolerance.
|
7859592 |
1994 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Genetic factors such as mutations in the HNF-1alpha and glucokinase genes may be important in the development of diabetes in Chinese people, especially when the disease is of early onset.
|
10588527 |
1999 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Mutations in the transcription factors HNF1A and HNF4A and in the β-cell potassium ATP channel components cause diabetes which responds to low dose and high dose sulfonylurea agents, respectively, while glucokinase mutations require no treatment.
|
27432078 |
2016 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In contrast, inactivating mutations of GCK result in diabetes, including a mild form (MODY2) and a severe form (permanent neonatal diabetes mellitus (PNDM)).
|
29044608 |
2018 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
|
11916951 |
2002 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This study was undertaken to test the hypothesis that the diabetes susceptibility gene on chromosome 20q12 responsible for maturity-onset diabetes of the young (MODY) in a large kindred, the RW family, results in characteristic alterations in the dose-response relationships between plasma glucose concentration and insulin secretion rate (ISR) that differentiate this form of MODY from MODY in subjects with glucokinase mutations.
|
7789636 |
1995 |
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This case raises the question as to whether hyperglycaemia in GCK-MODY may increase the risk of fetal caudal regression syndrome as reported in women with pre-existing diabetes mellitus.
|
30362177 |
2019 |