GIP, gastric inhibitory polypeptide, 2695

N. diseases: 110; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038187
Disease: Starvation
Starvation 		0.200 Biomarker phenotype RGD Starvation in the rat: effect on peptides of the gut and brain. 6140913 1983
CUI: C0029771
Disease: Other specified diseases of pancreas
Other specified diseases of pancreas 		0.200 Biomarker group RGD Adaptation of the small intestine to induced maldigestion in rats. Experimental pancreatic atrophy and acarbose feeding. 3892654 1985
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 Biomarker disease BEFREE The literature with respect to GIP is flooded with conflicting data especially with respect to its role in type 2 diabetes mellitus, obesity, type 1 diabetes mellitus and chronic pancreatitis. 8472632 1993
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.010 Biomarker disease BEFREE The literature with respect to GIP is flooded with conflicting data especially with respect to its role in type 2 diabetes mellitus, obesity, type 1 diabetes mellitus and chronic pancreatitis. 8472632 1993
CUI: C4525496
Disease: Hamster Insulinoma
Hamster Insulinoma 		0.010 GeneticVariation disease BEFREE Transfection of chimeric chloramphenicol acetyltransferase plasmids containing various deletions of the human gastric inhibitory polypeptide (GIP) promoter into hamster insulinoma (HIT T15) cells indicated that the region between -180 and +14 is sufficient for basal promoter activity. 8428636 1993
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.260 Biomarker disease RGD Feedback regulation of glucose-dependent insulinotropic polypeptide (GIP) secretion by insulin in conscious rats. 8059006 1994
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 Biomarker disease BEFREE The pathogenesis of AIMBAD appears to be heterogeneous, as recent reports have demonstrated GIP-mediated hypercortisolism and familial AIMBAD. 8038906 1994
CUI: C0001622
Disease: Adrenal Gland Hyperfunction
Adrenal Gland Hyperfunction 		0.010 Biomarker phenotype BEFREE The pathogenesis of AIMBAD appears to be heterogeneous, as recent reports have demonstrated GIP-mediated hypercortisolism and familial AIMBAD. 8038906 1994
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 GeneticVariation disease BEFREE To assess the possible role of the GIP receptor gene in genetic susceptibility to NIDDM, we have examined the allelic frequencies of Gly198Cys and Glu354Gln in NIDDM and control subjects. 8922354 1996
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 AlteredExpression disease BEFREE We conclude that food-dependent Cushing's syndrome results from the expression of GIP receptors on adrenocortical adenoma cells. 8784063 1996
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 AlteredExpression disease BEFREE We conclude that food-dependent Cushing's syndrome results from the expression of GIP receptors on adrenocortical adenoma cells. 8784063 1996
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma 		0.060 AlteredExpression disease BEFREE We conclude that food-dependent Cushing's syndrome results from the expression of GIP receptors on adrenocortical adenoma cells. 8784063 1996
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.010 Biomarker disease BEFREE Because the insulinotropic effect of GIP is reduced in NIDDM, it should be clarified whether defects in the GIP receptor gene contribute to the impaired insulin secretion in NIDDM. 8922354 1996
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.200 Biomarker disease RGD Conversely, GIP levels at 60 and 90 minutes following glucose ingestion in PTU-induced hypothyroid rats were higher than those in euthyroid rats. 9030821 1997
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.300 GeneticVariation disease BEFREE In conclusion, amino acid variants in the GIP receptor are not associated with random Type II diabetes in patients of Danish Caucasian origin or with altered GIP binding and GIP-induced cAMP production when stably transfected in Chinese hamster fibroblasts. 9794107 1998
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 AlteredExpression disease BEFREE In conclusion, the present data demonstrate that ectopic expression of functional GIP receptors is the main cause of food-dependent Cushing's syndrome. 9851802 1998
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 Biomarker disease BEFREE Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. 9745416 1998
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 Biomarker disease BEFREE We conclude that the GIPR overexpression and its coupling to steroidogenesis underlie GIP-dependent Cushing's syndrome. 9709947 1998
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 AlteredExpression disease BEFREE In conclusion, the present data demonstrate that ectopic expression of functional GIP receptors is the main cause of food-dependent Cushing's syndrome. 9851802 1998
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 Biomarker disease BEFREE Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. 9745416 1998
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 Biomarker disease BEFREE We conclude that the GIPR overexpression and its coupling to steroidogenesis underlie GIP-dependent Cushing's syndrome. 9709947 1998
CUI: C0206667
Disease: Adrenal Cortical Adenoma
Adrenal Cortical Adenoma 		0.060 Biomarker disease BEFREE Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis. 9745416 1998
CUI: C0001618
Disease: Tumors of Adrenal Cortex
Tumors of Adrenal Cortex 		0.010 AlteredExpression group BEFREE In situ hybridization demonstrated that expression of GIP receptor RNA was confined to the adrenocortical tumor cells. 9745416 1998
CUI: C0158850
Disease: Fetal Malnutrition
Fetal Malnutrition 		0.010 Biomarker disease BEFREE Incidentally, any defect in insulin secretion, whether in normoglycemic or hyperglycemic persons, could be due to other factors than primary beta-cell dysfunction: amyloid deposits in the pancreas (126), changes in insulin secretagogues (amylin, GLP-1, GIP, galanin) (127-130), early intrauterine malnutrition (131). 9715376 1998
CUI: C1510504
Disease: Fetal malnutrition without mention of light-for-dates
Fetal malnutrition without mention of light-for-dates 		0.010 Biomarker disease BEFREE Incidentally, any defect in insulin secretion, whether in normoglycemic or hyperglycemic persons, could be due to other factors than primary beta-cell dysfunction: amyloid deposits in the pancreas (126), changes in insulin secretagogues (amylin, GLP-1, GIP, galanin) (127-130), early intrauterine malnutrition (131). 9715376 1998