Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We present here a high-content screening method, based on the evaluation of fluorescent dye transfer rates between adjacent cells to monitor the function of GJs in U251 glioblastoma cells expressing high levels of Cx43.
|
31314551 |
2019 |
Childhood Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a region of CX43 (amino acids 266-283) exerts an important anti-tumor effect in patient-derived glioblastoma models that includes impairment of GSC migration and invasion.
|
28712848 |
2017 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells.
|
22294051 |
2012 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of cx43 in human glioblastoma cells significantly increased sensitivity to several common chemotherapeutic agents, including etoposide, paclitaxel (Taxol) and doxorubicin, compared with control-transfected cells.
|
11279616 |
2001 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Curcumin Promotes Connexin 43 Degradation and Temozolomide-Induced Apoptosis in Glioblastoma Cells.
|
30974966 |
2019 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we demonstrated that expression of Cx43 in human glioblastoma cells potentiated an apoptotic program under low-serum conditions.
|
11746825 |
2001 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, our data demonstrate that Cx43 controls the tumor phenotype of glioblastoma U251 cells and in particular, invasion capacity, through its localization in lipid rafts containing Cav-1.
|
21882259 |
2012 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicate that the "bystander" effects of functional gap junctions composed of connexin 43 enhance the antitumor effect of miR-124-3p in glioblastoma cells by transferring miR-124-3p to adjacent cells, thereby enhancing G0 /G1 cell cycle arrest.
|
25753094 |
2015 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By manipulation of Cx43 expression or gap junction function, we found that there were gap junction-dependent and independent effect of Cx43 on temozolomide (TMZ) sensitivity in U87 glioblastoma cells.
|
29115581 |
2018 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report here that glioblastoma is a heterogenous disease as regards Cx43 expression with presentations, in which Cx43 expression is unaltered, reduced or totally lost.
|
21779029 |
2011 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology.
|
12019157 |
2002 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To improve the effectiveness of this therapy, we compared an HSV vector (TOCX) expressing Cx43 in addition to TK with an isogenic tk vector (TOZ.1) for their abilities to induce bystander killing of Cx-positive U-87 MG human glioblastoma cells and Cx-negative L929 fibrosarcoma cells in vitro and in vivo.
|
10933914 |
2000 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that the loss of cx43 expression may play a role in the development of human gliomas and that cx43 acts as a tumor suppressor gene to human glioblastoma.
|
9823317 |
1998 |