Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In support of our experimental data, we observed a significant correlation between high SERP1 levels and poor patient outcome in glioblastoma patients.
|
24954504 |
2015 |
Angina, Unstable
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serp-1 has also been tested successfully in a Phase IIa clinical trial in unstable angina, representing a "first-in-class" therapeutic.
|
29227673 |
2018 |
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Univariate and multivariate Cox regression analysis further revealed SERP1 high expression was an independent factor for the prognosis of PDAC.
|
28902358 |
2017 |
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Serp-1) are being developed to treat systemic inflammatory syndromes such as cardiovascular disease in humans.
|
21658227 |
2011 |
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
Nontoxic, yet powerful neuroprotective, anti-inflammatory effects of Serp-1 may indicate this serpin protein as a potential attractive compound to treat SCI and similar syndromes involving massive injury to the white matter such as brain trauma and stroke.
|
30194604 |
2018 |
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In support of our experimental data, we observed a significant correlation between high SERP1 levels and poor patient outcome in glioblastoma patients.
|
24954504 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
The treatment of SERP1 to type 2 diabetes mellitus mice alleviated the hyperglycemia, increased glucose utilization of peripheral tissues of the liver and inhibited the liver injury.
|
28927592 |
2017 |
Diabetic Angiopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, the remarkable effects of SERP1 on reducing restenosis following vascular injury may contribute to future advancements in the treatment of diabetic vascular complications.
|
29656185 |
2018 |
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In support of our experimental data, we observed a significant correlation between high SERP1 levels and poor patient outcome in glioblastoma patients.
|
24954504 |
2015 |
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In support of our experimental data, we observed a significant correlation between high SERP1 levels and poor patient outcome in glioblastoma patients.
|
24954504 |
2015 |
High density lipoprotein measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Hyperglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The treatment of SERP1 to type 2 diabetes mellitus mice alleviated the hyperglycemia, increased glucose utilization of peripheral tissues of the liver and inhibited the liver injury.
|
28927592 |
2017 |
Impaired glucose tolerance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
SERP1-/- mice, made by targeted gene disruption, demonstrated growth retardation, increased mortality, and impaired glucose tolerance.
|
16705175 |
2006 |
Lupus vasculitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The Myxomavirus-derived protein Serp-1 has potent anti-inflammatory activity in models of vasculitis, lupus, viral sepsis, and transplant.
|
29227673 |
2018 |
Myxoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using myxoma virus and recombinant vaccinia virus constructs for experiments with tunicamycin and peptide N-glycosidase F, it is shown that the secreted SERP1 protein is modified by N-linked glycosylation.
|
8337817 |
1993 |
Neointimal hyperplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Importantly, intima media thickness (IMT) and neointimal hyperplasia were alleviated in the carotid artery of diabetic rats injected with SERP1 following balloon injury.
|
29656185 |
2018 |
Pancreatic Ductal Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, studies on the role of SERP1 in pancreatic ductal adenocarcinoma (PDAC) are still incomplete.
|
28902358 |
2017 |
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SERP1, RNASE 2 and STATA5 were suppressed in papillary thyroid cancer.
|
16171553 |
2005 |
Serum HDL cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |
Stomatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to report the first draft genome sequence of an Enterobacter cloacae isolate (SERP1) recovered from a snake with infectious stomatitis.
|
30448520 |
2018 |