Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 Biomarker disease BEFREE The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6. 31064870 2019
CUI: C0036220
Disease: Kaposi Sarcoma
Kaposi Sarcoma 		0.010 Biomarker disease BEFREE Here, we report the important roles of GW182 and DDX6, but not Dicer, Ago2 and DCP1A, in PB formation, and that Kaposi's sarcoma-associated herpesvirus (KSHV) lytic infection reduces PB formation through several specific interactions with viral RNA-binding protein ORF57. 31400113 2019
CUI: C0085786
Disease: Hamman-Rich syndrome
Hamman-Rich syndrome 		0.010 Biomarker disease BEFREE Anti-RNA binding protein positivity in idiopathic interstitial pneumonia. 30665514 2019
CUI: C0153676
Disease: Secondary malignant neoplasm of lung
Secondary malignant neoplasm of lung 		0.010 AlteredExpression disease BEFREE RBMS3 was downregulated in breast cancer and ectopic expression of RBMS3 contributed to inhibition of cell migration, invasion in vitro and lung metastasis in vivo. 30819235 2019
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.010 Biomarker disease BEFREE Taken together, the results of the present study demonstrated that SIRT1 deacetylated QKI 5, an RNA‑binding protein significantly affecting the synthesis of TG in the liver of the NAFLD mouse model. 30664220 2019
CUI: C2350236
Disease: Idiopathic Interstitial Pneumonias
Idiopathic Interstitial Pneumonias 		0.010 Biomarker disease BEFREE Anti-RNA binding protein positivity in idiopathic interstitial pneumonia. 30665514 2019
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 Biomarker disease BEFREE The RNA-Binding Protein HuR Confers Oxaliplatin Resistance of Colorectal Cancer By Upregulating CDC6. 31064870 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 Biomarker disease BEFREE The RNA-binding protein HuR plays several physiological roles in endothelial cells, but its relevance to atherosclerosis is not yet determined. 30340104 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 Biomarker disease BEFREE The RNA-binding protein HuR plays several physiological roles in endothelial cells, but its relevance to atherosclerosis is not yet determined. 30340104 2018
CUI: C0024198
Disease: Lyme Disease
Lyme Disease 		0.010 Biomarker disease BEFREE Borrelia burgdorferi SpoVG DNA- and RNA-Binding Protein Modulates the Physiology of the Lyme Disease Spirochete. 29632088 2018
CUI: C0085281
Disease: Addictive Behavior
Addictive Behavior 		0.010 AlteredExpression phenotype BEFREE Neuronal RNA-binding protein HuD regulates addiction-related gene expression and behavior. 29283498 2018
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors 		0.010 AlteredExpression group BEFREE Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27<sup>Kip1</sup> levels and poor prognosis. 30014466 2018
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.010 Biomarker phenotype BEFREE Recently, several reports have provided evidence that RBMS3 was deregulated in a diverse range of solid tumors and played a critical role in tumor progression. 28409548 2018
CUI: C0424295
Disease: Hyperactive behavior
Hyperactive behavior 		0.010 AlteredExpression phenotype BEFREE Here we report that HRPU-2, an RNA-binding protein homologous to mammalian heterogeneous nuclear ribonucleoprotein U (hnRNP U), plays an important role in regulating the expression of SLO-2 (a homolog of mammalian Slo2) in <i>Caenorhabditis elegans</i> Loss-of-function (<i>lf</i>) mutants of <i>hrpu-2</i> were isolated in a genetic screen for suppressors of a sluggish phenotype caused by a hyperactive SLO-2. 29217678 2018
CUI: C1337011
Disease: Well Differentiated Pancreatic Endocrine Tumor
Well Differentiated Pancreatic Endocrine Tumor 		0.010 AlteredExpression disease BEFREE Here, we report that loss of expression of the RNA-binding protein HuD correlates with low p27<sup>Kip1</sup> (p27) levels and poor prognosis in pancreatic NETs. 30014466 2018
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.010 Biomarker group BEFREE The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. 28504646 2017
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.010 Biomarker disease BEFREE The aim of this study was to examine RNA binding protein (RNABP) HuR/TTP axis in endometriosis patients compared to menstrual stage matched healthy fertile controls in hopes of better understanding their contribution to the pathogenesis of endometriosis. 28724967 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.010 GeneticVariation phenotype BEFREE Silencing of the RNA-binding protein HuR attenuates hyperalgesia and motor disability in experimental autoimmune encephalomyelitis. 28599923 2017
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE These findings implicated that RBMS3 and nuclear HIF1A could act as prognostic biomarkers and therapeutic targets for GC. 27902480 2017
CUI: C0025286
Disease: Meningioma
Meningioma 		0.010 AlteredExpression disease BEFREE Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia. 28493484 2017
CUI: C0236642
Disease: Pick Disease of the Brain
Pick Disease of the Brain 		0.010 Biomarker disease BEFREE TDP-43 is a primarily nuclear RNA-binding protein, whose abnormal phosphorylation and cytoplasmic aggregation characterizes affected neurons in patients with amyotrophic lateral sclerosis and frontotemporal dementia. 28663553 2017
CUI: C0278877
Disease: Adult Meningioma
Adult Meningioma 		0.010 AlteredExpression disease BEFREE Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia. 28493484 2017
CUI: C1536999
Disease: cancer angiogenesis
cancer angiogenesis 		0.010 Biomarker phenotype BEFREE RNA binding motif, single-stranded interacting protein 3 (RBMS3) is a tumor suppressor gene located in this region and mediates cancer angiogenesis. 27902480 2017
CUI: C1762616
Disease: Meningioma, benign, no ICD-O subtype
Meningioma, benign, no ICD-O subtype 		0.010 AlteredExpression disease BEFREE Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia. 28493484 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.010 GeneticVariation disease BEFREE The association of RBMS3 was further evidenced by imputation in which rs13072846 (P = 4.89 × 10<sup>-5</sup>) was identified and confirmed as female PSS associating SNP within the same LD with rs13079920. 27503288 2016