|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
β III-Tubulin showed the highest expression (P = 0.002), and its expression was more frequent in the AC than in the SCC component (P = 0.013).
|
25257380 |
2015 |
|
Adenocarcinoma
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
Prevalence for methylation of TNFRSF10C, BHLHB5 and BOLL was significantly higher in adenocarcinomas from never smokers than smokers.
|
19435948 |
2009 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Special focus is placed on (1) the aberrant overexpression of βIII-tubulin, a survival factor associated with hypoxic tumor microenvironment and dynamic instability of microtubules; (2) the ectopic overexpression of γ-tubulin, which in addition to its conventional role as a microtubule-nucleating protein has recently emerged as a transcription factor interacting with oncogenes and kinases; (3) the microtubule-severing ATPase spastin and its emerging role in cell motility of glioblastoma cells; and (4) the modulating role of posttranslational modifications of tubulin in the context of interaction of microtubules with motor proteins.
|
25976261 |
2015 |
|
Age related macular degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, we noticed significant intracellular overexpression of β-III-tubulin in the cells derived from AMD patients.
|
21847578 |
2011 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with Glanzmann thrombasthenia lacking platelet glycoprotein alpha(IIb)beta(3) (GPIIb/IIIa) and alpha(v)beta(3) receptors are not protected from atherosclerosis.
|
11877352 |
2002 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with Glanzmann thrombasthenia lacking platelet glycoprotein alpha(IIb)beta(3) (GPIIb/IIIa) and alpha(v)beta(3) receptors are not protected from atherosclerosis.
|
11877352 |
2002 |
|
Auditory neuropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that SGN damage following the injection of DT in mice with Bhlhb5-Cre <sup>+/-</sup> and iDTR <sup>+/-</sup> is likely to be a good AN model of demyelination.
|
28743950 |
2017 |
|
Auditory neuropathy spectrum disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that SGN damage following the injection of DT in mice with Bhlhb5-Cre <sup>+/-</sup> and iDTR <sup>+/-</sup> is likely to be a good AN model of demyelination.
|
28743950 |
2017 |
|
Breast Carcinoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Integrin alpha-2 and beta-3 gene polymorphisms and breast cancer risk.
|
16317580 |
2006 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Our results suggest that downregulation of tumor βIII- and βV-tubulins is correlated with taxane resistance in BC.
|
30126203 |
2018 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
ABCB1, βI, and βIII tubulin might contribute to the MDR of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer.
|
24894670 |
2014 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Among these neuronal predominant markers, in silico analysis revealed overexpression of βIII-tubulin (TUBB3) in breast cancer brain metastases (BCBM) and its expression was significantly associated with distant metastases.
|
25724666 |
2015 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
βIII-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer.
|
28025079 |
2017 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, the CA-4 resistant human lung carcinoma shows alteration of βI and βIII isotype levels, a higher expression of βI tubulin isotype and a decreased expression of βIII tubulin isotypes has been reported in drug resistant cell lines.
|
30831055 |
2020 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Sox9 allows the survival of OC cells upon hypoxic condition, through the activation of βIII-tubulin expression and its aberrant activation in OC is prominent in patients with aggressive OC.
|
24661907 |
2014 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Special focus is placed on (1) the aberrant overexpression of βIII-tubulin, a survival factor associated with hypoxic tumor microenvironment and dynamic instability of microtubules; (2) the ectopic overexpression of γ-tubulin, which in addition to its conventional role as a microtubule-nucleating protein has recently emerged as a transcription factor interacting with oncogenes and kinases; (3) the microtubule-severing ATPase spastin and its emerging role in cell motility of glioblastoma cells; and (4) the modulating role of posttranslational modifications of tubulin in the context of interaction of microtubules with motor proteins.
|
25976261 |
2015 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Knockdown of the Sp1 transcription factor, by siRNA silencing, also upregulated βIII-tubulin expression in osteosarcoma cells, suggesting that miR-34a indirectly affects Sp1.
|
28275089 |
2017 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that spectrins βI and βIII may be used to differentiate well differentiated HCC from FNH or HA, and poorly differentiated HCC from CC, respectively.
|
30798076 |
2019 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The methylation of the genes Ade-nomatous polyposis coli (APC), glycogen synthase kinase-beta-3 (GSK3beta) and eyes absent 4 (EYA4) was analyzed in 12 colon cancer and 12 normal tissues.
|
16670426 |
2006 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Integrin alpha-2 and beta-3 gene polymorphisms and colorectal cancer risk.
|
18836731 |
2009 |
|
Colorectal Carcinoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms of integrin alpha-2 and beta-3 genes are not associated with relapse-free and overall survival in colorectal cancer patients.
|
21508388 |
2011 |
|
Colorectal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
This study aimed at examining whether βIII-tubulin (TUBB3), present in various types of normal tissues and cancer, is a biomarker for the response of colorectal neoplasms to paclitaxel.
|
30711942 |
2019 |
|
Depressed mood
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The association between GNβ3 C825T and depression risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study.
|
26147511 |
2015 |
|
Depressive disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The association between GNβ3 C825T and depression risk were assessed by odd ratios (ORs) and their 95% confidence intervals (CIs) for each study.
|
26147511 |
2015 |
|
Diphtheria
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, Cre-inducible diphtheria toxin receptor (iDTR <sup>+/+</sup> ) mice were cross-mated with mice containing Cre (Bhlhb5-Cre <sup>+/-</sup> ) specific to spiral ganglion neurons (SGNs).
|
28743950 |
2017 |