|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, UBE2S could be a potential target for lung adenocarcinoma.[BMB Reports 2018; 51(12): 642-647].
|
30545437 |
2018 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, knockdown of UBE2S expression inhibited NHEJ-mediated DSB repair and rendered glioblastoma cells more sensitive to chemotherapy.
|
27593939 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The UBE2S expression in PDAC was measured by immunohistochemistry and qRT-PCR.
|
31814735 |
2019 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that overexpression of E2-EPF protein correlated with estrogen receptor (ER) negativity in breast cancer specimens and that its expression is cell cycle-regulated, suggesting a potential function for E2-EPF in cell cycle progression.
|
17710163 |
2007 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Since UBE2S is an ubiquitin-conjugating enzyme and this enzyme activity is involved in DNA damage repair, HCV-infected cells are more sensitive to DNA damage, and thus UBE2S may contribute to viral oncogenesis.
|
30381483 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
UBE2S might contribute to Hif-1α signaling in cervical cancer.
|
28277581 |
2017 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
UBE2S might contribute to Hif-1α signaling in cervical cancer.
|
28277581 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, knockdown of UBE2S expression inhibited NHEJ-mediated DSB repair and rendered glioblastoma cells more sensitive to chemotherapy.
|
27593939 |
2017 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The findings in this study extend our mechanistic understanding of the mesoendodermal cell fate commitment, and provide UBE2S as a putative target for human CRC therapy.
|
29674637 |
2018 |
|
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
UBE2S mediates tumor progression via SOX6/β-Catenin signaling in endometrial cancer.
|
30690078 |
2019 |
|
Esophageal carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Activation of NF-kappa B, increase of E2-EPF ubiquitin carrier protein and subsequent epithelial-mesenchymal transition might be the underlying mechanisms of the more aggressive tumor growth in IL-1 beta-positive esophageal cancer.
|
21912958 |
2012 |
|
Esophageal carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of E2-EPF ubiquitin carrier protein (UCP) in esophageal cancer remains relatively unstudied.
|
19083192 |
2009 |
|
Esophageal Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
However, the role of E2-EPF ubiquitin carrier protein (UCP) in esophageal cancer remains relatively unstudied.
|
19083192 |
2009 |
|
Esophageal Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Activation of NF-kappa B, increase of E2-EPF ubiquitin carrier protein and subsequent epithelial-mesenchymal transition might be the underlying mechanisms of the more aggressive tumor growth in IL-1 beta-positive esophageal cancer.
|
21912958 |
2012 |
|
Extraskeletal Myxoid Chondrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these data suggest UBE2S may serve as a promising prognostic factor and function as an oncogene in EMC.
|
30690078 |
2019 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, knockdown of UBE2S expression inhibited NHEJ-mediated DSB repair and rendered glioblastoma cells more sensitive to chemotherapy.
|
27593939 |
2017 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, knockdown of UBE2S expression inhibited NHEJ-mediated DSB repair and rendered glioblastoma cells more sensitive to chemotherapy.
|
27593939 |
2017 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
E2-EPF levels were low in normal brain tissue samples but high in glioma nuclei.
|
28384045 |
2017 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.
|
30903204 |
2019 |
|
Hepatitis C
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that HCV counteracts antiviral activity of UBE2S to optimize viral propagation and may contribute to HCV-induced liver pathogenesis.<b>IMPORTANCE</b> Protein homeostasis is essential to normal cell function.
|
30381483 |
2019 |
|
High grade glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ectopic E2-EPF levels in high-grade glioma were significantly higher than in low-grade glioma (p < 0.01).
|
28384045 |
2017 |
|
Intellectual Disability
|
0.010 |
Biomarker
|
group |
BEFREE |
Other dementia-related proteins, namely Tau and apoE, interact with and are ubiquitinated via the ACR in vitro This, and the evidence that CRBN and CUL4B are linked to intellectual disability, prompts us to hypothesize a pathogenic mechanism, in which APP acts as a modulator of E3 ubiquitin-protein ligase(s), shared by distinct neuronal disorders.
|
27325702 |
2016 |
|
intracranial glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to reveal how the level of E2-EPF relates to prognosis in brain glioma.
|
28384045 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings might promote the understanding of the relationship between UBE2S overexpression and oral cancer proliferation, indicating that UBE2S would be a potential biomarker of and therapeutic target in OSCCs.
|
28257844 |
2017 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression.
|
30903204 |
2019 |