|
Leukemia, Myelocytic, Acute
|
0.110 |
Biomarker
|
disease |
BEFREE |
Gene set enrichment analysis on microarray data of AML patient cells and Western blot analysis for the isoprenylated proteins DnaJ and Rap1 on murine and AML patient MNCs demonstrated that in vivo simvastatin treatment resulted in inhibition of geranylgeranylation in murine MNCs and in a subset of patient AML MNCs.
|
22120639 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
RABEX-5 expression was examined in breast cancer, benign tumor and normal breast tissues by immunohistochemistry and western blot.
|
23941575 |
2013 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide compelling evidence of a novel role for JAM-A in driving breast cancer cell migration via activation of Rap1 GTPase and β1-integrin.
|
21429211 |
2011 |
|
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
While recent research has shown that expression of RABEX-5 in breast cancer and colorectal cancer has a crucial impact on tumor development, there is little information regarding RABEX-5 expression in prostate cancer.
|
24716822 |
2014 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
We will next discuss the role of the FAK/ERK axis, and possibly Rap1, in mediating CAP1 signals to control breast cancer cell adhesion, invasiveness, and proliferation, largely based on our latest findings.
|
31151140 |
2019 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Taken together, these results show that Rap1 is involved in the activation of MAPK pathway and integrin activation in human melanoma and suggest a potential role for Rap1 in melanoma tumorigenesis and metastasis.
|
16912161 |
2006 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our broad-in-depth work suggests that SHARPIN promotes melanoma development via p38 and JNK/c-Jun pathways through upregulation of Rap1 expression.
|
31401046 |
2020 |
|
melanoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The Mig-10/RIAM/lamellipodin (MRL) family member Rap1-GTP-interacting adaptor molecule (RIAM) interacts with active Rap1, a small GTPase that is frequently activated in tumors such as melanoma and prostate cancer.
|
21454517 |
2011 |
|
melanoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Overexpression of Rap1GAP in melanoma cells blocks Rap1 activation and extracellular signal-regulated kinase (ERK) phosphorylation and inhibits melanoma cell proliferation and survival.
|
19147557 |
2009 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Gene expression analyses of liver and visceral white fat from Rap1-deficient mice before the onset of obesity show deregulation of metabolic programs, including fatty acid, glucose metabolism, and PPARα signaling.
|
23791526 |
2013 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
Nontelomeric role for Rap1 in regulating metabolism and protecting against obesity.
|
23791522 |
2013 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
(2013) now extend this link, demonstrating that deletion of the telomere binding protein RAP1 leads to obesity and insulin resistance.
|
23809762 |
2013 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
As hepatic steatosis and obesity have been related to increased liver cancer in mice and humans, we set out to address whether RAP1 deficiency resulted in increased liver cancer upon chemical liver carcinogenesis.
|
30307978 |
2018 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We will next discuss the role of the FAK/ERK axis, and possibly Rap1, in mediating CAP1 signals to control breast cancer cell adhesion, invasiveness, and proliferation, largely based on our latest findings.
|
31151140 |
2019 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Our findings provide compelling evidence of a novel role for JAM-A in driving breast cancer cell migration via activation of Rap1 GTPase and β1-integrin.
|
21429211 |
2011 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
While recent research has shown that expression of RABEX-5 in breast cancer and colorectal cancer has a crucial impact on tumor development, there is little information regarding RABEX-5 expression in prostate cancer.
|
24716822 |
2014 |
|
Breast Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
RABEX-5 expression was examined in breast cancer, benign tumor and normal breast tissues by immunohistochemistry and western blot.
|
23941575 |
2013 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Bioinformatic analysis demonstrated that Proteoglycans, Fatty acid biosynthesis, ErbB, Hippo, TGF-beta, Wnt, Rap1, AMPK and Ras pathways were the most prominent pathways enriched in NSCLC EV miRNA signatures.
|
31293647 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Hence, our results demonstrate that the cytoplasmic RAP1-NF-κB-BCL2 axis represents a key pathway to cisplatin resistance in NSCLC cells, identifying RAP1 as a marker and a potential therapeutic target for cisplatin resistance of NSCLC.
|
28518145 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings revealed that inhibition of Rap1/cdc42 signaling by active compounds 5-methylcoumarin-4-cellobioside and mangiferin from BL02 might be potentially effective therapy for NSCLC.
|
31465829 |
2019 |
|
Squamous cell carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Because both rap1A and rap1B isoforms of rap1 are expressed in SCC, the rap1GAP inactivation of both rap1 isoforms was verified using cells transfected with EGFP-rap1A or EGFP-rap1B or co-transfected with FLAG-tagged rap1GAP.
|
16436672 |
2006 |
|
Squamous cell carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
RAP1 (RAS proximate 1), a small GTP-binding protein of the RAS superfamily, is a putative oncogene that is highly expressed in several malignant cell lines and types of cancers, including some types of squamous cell carcinoma.
|
25856570 |
2015 |
|
Squamous cell carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Rap1 is variably expressed in whole cell lysates of squamous cell carcinoma (SCC) cell lines.
|
13679863 |
2003 |
|
Papillary thyroid carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In addition, upon analysis of all samples for shelterin proteins, we observed a significant decrease in POT1 and RAP1 protein expression in the blood of FPTC patients compared with SPTC subjects.
|
22304389 |
2012 |