|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
G Protein-coupled Receptor 17 (GPR17) is phylogenetically related to the purinergic receptors emerged as a potential drug target for multiple sclerosis, Parkinson disease, Alzheimer disease and cancer.
|
28827203 |
2018 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
This ability of R12 highlights its therapeutic potential for treating AD pathology.
|
30916478 |
2019 |
|
Anterior Cerebral Circulation Infarction
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.
|
18974869 |
2008 |
|
Anterior Circulation Brain Infarction
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.
|
18974869 |
2008 |
|
Bloom Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that BLM significantly increased GPR17 expression, the mRNA synthesis and release of inflammatory cytokines including TNF-α, IL-6 and TGF-β1 in murine RAW 264.7 macrophage cells.
|
30036769 |
2018 |
|
Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression.
|
30640576 |
2019 |
|
Brain Infarction
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Magnetic Resonance Imaging in living mice showed that the in vivo pharmacological or biotechnological knock down of GPR17 markedly prevents brain infarct evolution, suggesting GPR17 as a mediator of neuronal death at this early ischemic stage.
|
18974869 |
2008 |
|
Brain Infarction, Posterior Circulation
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.
|
18974869 |
2008 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
There was a significant genetic correlation between ovarian and breast cancer (R12 = .484).
|
2491011 |
1989 |
|
Cerebral Infarction
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, being GPR17 completely downregulated in myelin-producing oligodendrocytes, its actual role in determining the final fate of OPCs after cerebral ischemia is still uncertain.
|
28594400 |
2017 |
|
Cerebral Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
GPR17 mediates microglial inflammation in the chronic phase of cerebral ischemia and regulates allergic pulmonary inflammation.
|
30036769 |
2018 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
GPR17 is believed to be a novel target for the development of new therapeutic approaches to human stroke and multiple sclerosis.
|
28223679 |
2017 |
|
Cerebrovascular accident
|
0.040 |
AlteredExpression
|
group |
BEFREE |
GPR17, a receptor transiently expressed on early OPCs, has emerged as a target to implement stroke repair through stimulation of OPC maturation.
|
28594400 |
2017 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression.
|
30640576 |
2019 |
|
Cerebrovascular accident
|
0.040 |
Biomarker
|
group |
BEFREE |
Against this background, we have examined the neuroprotective efficacy of arginine-rich protamine peptides, a cyclic (R12-c) poly-arginine peptide and a R22 poly-arginine peptide, as well as arginine peptides containing tryptophan or other amino acids (phenylalanine, tyrosine, glycine or leucine) in in vitro glutamic acid excitotoxicity and in vivo rat permanent middle cerebral artery occlusion models of stroke.
|
28523591 |
2017 |
|
Chronic heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus further research into the therapeutic potential of BB-R12 for patients with chronic heart failure appears warranted.
|
25876005 |
2015 |
|
Chronic rhinosinusitis with nasal polyps
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the expression of GPR17 and its correlation with CysLT1R in the 2 CRSwNP subsets.
|
29161055 |
2018 |
|
CNS disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
The absence of Gpr17 enhances remyelination is correlate with the activated Erk1/2 (phospho-Erk1/2).Being a membrane receptor, Gpr17 represents an ideal druggable target to be exploited for innovative regenerative approaches to acute and chronic CNS diseases.
|
29540737 |
2018 |
|
Congenital chromosomal disease
|
0.010 |
Biomarker
|
group |
BEFREE |
There were only single published cases of most small rings but there were three r(8) cases, two r(1) cases, two r(12) cases, and two r(20) cases, uncomplicated by the presence of other chromosome abnormalities.
|
7802042 |
1994 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
These pilot results suggest cardiac-specific gene therapy using BB-R12 may reverse cardiac dysfunction by myosin activation in a large-animal heart failure model with no observed safety concerns.
|
25876005 |
2015 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The methylation of genes ADCY4, ADCY6 and GPR17, as well as the gonadotropin-releasing hormone signaling pathway, was newly found to be potentially associated with OA.They may be novel OA markers.
|
27810435 |
2016 |
|
Demyelinating Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression.
|
30640576 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression.
|
30640576 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The GPR17 receptor is an enigmatic receptor and an interesting therapeutic target in a variety of brain disorders and demyelinating diseases such as multiple sclerosis, stroke, schizophrenia, and depression.
|
30640576 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on previously reported GPR17 activation by emergency signals (e.g., Stromal Derived Factor-1), we propose that a marked inflammatory milieu, such as that reproduced in EAE, induces GPR17 overactivation resulting in impaired downregulation, untimely and prolonged permanence in OPCs, leading, in turn, to differentiation blockade.
|
29424466 |
2018 |