|
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These data suggest the oncogenic abilities of TRIM59 in osteosarcoma, which promote osteosarcoma cell proliferation, migration and invasion.
|
27121462 |
2016 |
|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.
|
26634245 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TRIM59 was knocked down and overexpressed in gastric cancer cell lines, and the effects on proliferation, clone formation, migration, and growth of xenograft tumors in nude mice were assessed.
|
25046164 |
2014 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Mechanistically, TRIM59 play a key role in promoting LC growth and metastasis through regulation of extracellular-signal regulated protein kinase (ERK) signalling pathway and epithelial-to-mesenchymal transition (EMT)-markers, as validated by loss-of-function studies.
|
30515965 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Our recent study has demonstrated that TRIM59, an E3 ligase upregulated in metastatic breast cancer, is required for cancer cell survival and metastasis.
|
30653426 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Moreover, they highlight the relevance of TRIM59 in macrophages as a potential regulator of tumor metastasis and suggest TRIM59 could serve as a novel target for cancer immunotherapy.
|
31600735 |
2019 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The aim of the present study was to examine the role of tripartite motif containing 59 (TRIM59) in cell metastasis in medulloblastoma.
|
29805559 |
2018 |
|
Neoplasm Metastasis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we found that TRIM59 expression was increased and positively associated with histological grades (<i>P</i> = 0.000), FIGO stages (<i>P</i> = 0.016), and metastasis (<i>P</i> = 0.027) in ovarian cancer.
|
30585270 |
2018 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Finally, we found that p53 protein expression level was regulated by TRIM59, so we proposed that TRIM59 may enhance HCC cell proliferation and metastasis through p53 signaling pathway.
|
29442042 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, we investigated the role of TRIM59 in CRC growth and metastasis.
|
28534983 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, univariate and multivariate Cox's regression analyses indicated that TRIM59 was an independent prognostic factor in tumor tissue as compared with age, gender, tumor stage, node stage, and metastasis.
|
28789440 |
2017 |
|
Neoplasm Metastasis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
The current study investigated the role of the tripartite motif (TRIM) family protein TRIM59 in osteosarcoma growth and metastasis.
|
27121462 |
2016 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
TRIM59, a member of the TRIM family of proteins, has been reported to be involved in the carcinogenesis of multiple types of tumors.
|
31770215 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
TRIM59 has been recently implicated in the carcinogenesis of several cancers such as lung cancer, gastric cancer, and bladder cancer.
|
30175868 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Our study identifies TRIM59 as a new regulator of oncogenic EGFR/STAT3 signaling and as a potential therapeutic target for GBM patients with EGFR activation.<b>Significance:</b> These findings identify a novel component of the EGFR/STAT3 signaling axis in the regulation of glioma tumorigenesis.<i></i>.
|
29386185 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
However, little is known about the relationship between Trim59 and bladder carcinogenesis.
|
28331343 |
2017 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
TRIM59 knockdown was shown to inhibit tumorigenesis in mice.
|
27981550 |
2016 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
TRIM59 interacts with P53, promoting its ubiquitination and degradation, and TRIM59 might promote gastric carcinogenesis via this mechanism.
|
25046164 |
2014 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Restricted TRIM59 gene upregulation in the prostate revealed the full potential for inducing tumorigenesis, similar to the expression of SV40 Tag, and coincided with the upregulation of genes specific to the Ras signaling pathway and bridging genes for SV40 Tag-mediated oncogenesis.
|
21593385 |
2011 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10.
|
30653426 |
2019 |
|
Malignant neoplasm of breast
|
0.040 |
Biomarker
|
disease |
BEFREE |
Next, miR-148b-3p mimic or inhibitor and siRNA against TRIM59 were delivered into the breast cancer cells (MDA-MB-231) to alter the expression of miR-148b-3p and TRIM59 so as to evaluate their respective effects on breast cancer cellular processes.
|
31696054 |
2019 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Our meta-analysis suggests that higher TRIM59 expression predicts poor prognosis in cancer patients, and it may therefore serve as a promising prognostic factor.
|
31770215 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Genetic depletion of TRIM59 suppresses cancer metastasis by promoting RNFT1-induced K63 polyubiquitination and SQSTM1-directed autophagic degradation of PDCD10, thereby boosting ROCK (Rho associated coiled-coil containing protein kinase)-induced actomyosin contractility and enhancing CDH1-mediated adhesion formation.
|
30653426 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Both TRIM59 and p65 were up-regulated in NSCLC.
|
30932261 |
2019 |
|
Breast Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
TRIM59 deficiency curtails breast cancer metastasis through SQSTM1-selective autophagic degradation of PDCD10.
|
30653426 |
2019 |