|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Progranulin as a therapeutic target for dementia.
|
29889573 |
2018 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
LHGDN |
Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21.
|
16862115 |
2006 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
It also demonstrates that half of the patients with a PGRN mutation in our series had no apparent family history of dementia.
|
17436289 |
2007 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We studied the clinical and pathologic features of HpScl in 205 consecutive patients with dementia who came to autopsy from 1997 to 2008, focusing on associations with TAR DNA-binding protein 43 (TDP-43) pathology and allelic variants in the progranulin (GRN) and apolipoprotein E (APOE).
|
21346515 |
2012 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Mutations in progranulin (GRN) cause heterogeneous clinical syndromes, including behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), corticobasal syndrome (CBS) and Alzheimer-type dementia (AD-type dementia).
|
30921613 |
2019 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
An autosomal dominant mutation in GRN, the gene for PGRN, leads to neuronal atrophy in the frontal and temporal lobes, resulting in the disease frontotemporal lobar dementia.
|
19795409 |
2009 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
LHGDN |
We were able to demonstrate progranulin immunoreactivity throughout the medial temporal lobe in all dementia with Lewy body cases.
|
18955727 |
2009 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
This case confirms progranulin plasma levels as a reliable biomarker to identify GRN deletion carriers and discriminate between FTLD and other dementias which may mimic it.
|
19683260 |
2009 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Due to the functions of PGRN in neuronal survival and the clinicopathological overlaps between FTD and other dementias it is likely that reduced PGRN expression is associated with the progression of other neurodegenerative brain diseases including Alzheimer's disease.
|
17168647 |
2006 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Once a cure for GRN-related neurodegeneration becomes available, this biomarker will be an important tool in the effort to personalize treatment of dementia.
|
20387302 |
2010 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17.
|
18322394 |
2008 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia.
|
18183624 |
2008 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The GRN gene should be analyzed in patients with PCA, particularly when the damage progresses to anterior cerebral regions and a family history of dementia is present.
|
25546130 |
2015 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
|
17439980 |
2007 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration.
|
16950801 |
2006 |
|
Dementia
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Being predictive for GRN null mutations, plasma progranulin dosage should be included in diagnostic work-up of dementia.
|
20930271 |
2011 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation.
|
17620546 |
2007 |
|
Dementia
|
0.500 |
Biomarker
|
disease |
BEFREE |
The discovery that mutations in the gene encoding for progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases leading to dementia has brought renewed interest in progranulin and its functions in the central nervous system.
|
24018267 |
2014 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.
|
17345602 |
2007 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe a case of late onset frontotemporal dementia carrying the g.1977_1980 delCACT (Thr272fs) mutation in progranulin (GRN) gene, characterized by a positive family history for dementia and a clinical phenotype resembling dementia with Lewy bodies.
|
23478307 |
2013 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia.
|
22312439 |
2012 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers.
|
24005336 |
2013 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Progranulin mutations were identified as a major cause of FTLD and a potential susceptibility factor for other forms of dementia.
|
19640594 |
2009 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This is consistent with the finding that miR-659 binding to the high risk T allele of rs5848 may augment translational inhibition of GRN and alter risk of FTD and possibly other dementias.
|
21047645 |
2011 |
|
Dementia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
It also demonstrates that half of the patients with a PGRN mutation in our series had no apparent family history of dementia.
|
17436289 |
2007 |