|
Congenital contractural arachnodactyly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of CD147 and MCT-1/4 in human CCA tissues were determined by immunohistochemistry.
|
31729681 |
2020 |
|
Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
MCT1 is an attractive transporter in brain diseases and cancers.
|
31631816 |
2019 |
|
Lymphoma, Large-Cell, Follicular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that expression of MCT1 in the NHL tumour compartment was significantly associated with a poor clinicopathological profile.
|
30790227 |
2019 |
|
Adult Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma.
|
30790227 |
2019 |
|
Childhood Non-Hodgkin Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma.
|
30790227 |
2019 |
|
Inflammatory pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In our study, we hypothesized that MCT 1 in the spinal dorsal horn plays an important part in chronic inflammatory pain.
|
31807055 |
2019 |
|
Generalized seizures
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found that among all the patients, MCT1 rs60844753 CC carriers have higher incidence of VPA-resistance than CG carriers (P = 0.05), and in subgroup of generalized seizure, ABCC2 rs3740066 CC carriers had higher frequency of VPA resistance than TC + TT carriers (P = 0.03).
|
30952578 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
MCT1 may act as a biomarker for ESCC to identify patients with poor outcomes.
|
30720131 |
2019 |
|
Muscle damage
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Israeli runners of Ethiopian origin had a greater frequency of the PPARD CC + PARGC1A Gly/Gly polymorphism, associated with improved endurance performance, compared with Israeli runners of non-Ethiopian origins (24 vs. 3%, respectively, p < 0.01); a lower frequency of the ACSL AA polymorphism, favoring endurance trainability (8 vs. 20%, respectively, p < 0.05); a greater frequency of the ACTN3 RR polymorphism, associated with sprint performance (35 vs. 20%, respectively, p < 0.05); a greater frequency of the MCT1 AA genotype, associated with improved lactate transport (65 vs. 45%, respectively, p < 0.05); and a lower frequency of IL-6 174C carriers, associated with reduced postexercise muscle damage (27 vs. 40%, respectively, p < 0.01).
|
30741858 |
2019 |
|
Adenocarcinoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vitro</i> effects on extracellular flux via glycolysis and mitochondrial stress tests suggest that candidate compounds 3 and 9 disrupt glycolysis and OxPhos efficiently in MCT1 expressing colorectal adenocarcinoma WiDr and MCT4 expressing triple negative breast cancer MDA-MB-231 cells.
|
31040927 |
2019 |
|
Channelopathies
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pancreatic K<sub>ATP</sub>, Non-K<sub>ATP</sub>, and some calcium channelopathies and MCT1 transporter defects can lead to various forms of hyperinsulinaemic hypoglycaemia (HH).
|
31137773 |
2019 |
|
Hyperinsulinemic hypoglycemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pancreatic K<sub>ATP</sub>, Non-K<sub>ATP</sub>, and some calcium channelopathies and MCT1 transporter defects can lead to various forms of hyperinsulinaemic hypoglycaemia (HH).
|
31137773 |
2019 |
|
Lymphoma, Non-Hodgkin, Familial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that expression of MCT1 in the NHL tumour compartment was significantly associated with a poor clinicopathological profile.
|
30790227 |
2019 |
|
Choriocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Valproic acid transport in the choriocarcinoma placenta cell line JEG-3 proceeds independently of the proton-dependent transporters MCT1 and MCT4.
|
30341000 |
2018 |
|
Hyperglycemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Experiment 2 showed lower Glut1, Gys1 and Mct4 expression and higher Mct1 expression in the hyperglycemia group, relative to the control group (p < 0.05).
|
29532970 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nuclear factor E2-related factor-2 has a differential impact on MCT1 and MCT4 lactate carrier expression in colonic epithelial cells: a condition favoring metabolic symbiosis between colorectal cancer and stromal cells.
|
28846107 |
2018 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The identification of DENR and MCTS1 target transcripts will serve as a basis for future studies aimed at understanding the mechanistic involvement of DENR and MCTS1 in cancer and autism.
|
28623304 |
2017 |
|
Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, AZD3965 caused lactate accumulation in the Raji Burkitt's lymphoma model and significant tumor growth inhibition.
|
29050199 |
2017 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
To understand how this resistance to steatosis develops, we used HFD fed wildtype mice with hepatic steatosis and MCT1 haploinsufficient mice to study hepatic metabolism.
|
29092796 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MCT1 expression at the time of diagnosis can assist on the identification of AML patients that will benefit from BPA therapy.
|
29137304 |
2017 |
|
Secondary malignant neoplasm of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
Together, these data demonstrate that lactate released by glycolytic breast carcinoma cells in the bone microenvironment promotes the formation of osteolytic lesions, and provide the rationale for further studies on the use of MCT1 targeting as a novel therapeutic approach in advanced cancer patients with BM.
|
28866133 |
2017 |
|
Adult Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, AZD3965 caused lactate accumulation in the Raji Burkitt's lymphoma model and significant tumor growth inhibition.
|
29050199 |
2017 |
|
Childhood Burkitt Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, AZD3965 caused lactate accumulation in the Raji Burkitt's lymphoma model and significant tumor growth inhibition.
|
29050199 |
2017 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
MCT1 and MCT4 are prognostic factors in esophageal adenocarcinoma.
|
28206968 |
2017 |
|
Recurrent tumor
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Clinical evidence further confirms that high expression of MCT-1 is associated with an increase in YY1, EGFR and MnSOD expression, accompanied by tumor recurrence, poor overall survival and EGFR mutation status in patients with lung cancers.
|
28394354 |
2017 |