Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Two NMDA receptor subunit genes, GRIN1 and GRIN2A, are both good candidate genes for schizophrenia.
|
16476413 |
2006 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These observations suggest that, in schizophrenia, a number of CB-containing cells that normally do not express NR2A might become NR2A-expressing or, perhaps not mutually exclusively, the number of CB-expressing cells might be increased and these cells express NR2A.
|
18585682 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we used in situ hybridization to measure the expression of NMDA subunits (NR1, NR2A-D), and associated intracellular proteins (NF-L, PSD95, and SAP102) in a second, younger cohort from the Stanley Foundation Neuropathology Consortium, which included patients with both schizophrenia and affective disorders.
|
15054476 |
2004 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the role of the N-methyl-D-aspartate receptor 2A subunit (GRIN2A) gene on 16p13.3, a region thought to be linked to bipolar disorder, (1) because in a prior study we identified a functional and polymorphic (GT)n repeat in the 5' regulatory region of the gene, with longer alleles showing lower transcriptional activity and an over representation in schizophrenia, and (2) because of the suggestion of a genetic overlap between affective disorder and schizophrenia.
|
12809987 |
2003 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The aim of this study was to determine (1) whether SNP variation in the genes (GRIN1, GRIN2A, GRIN2B, GRIN2C, and GRIN2D) encoding the NMDA receptor were associated with schizophrenia; (2) whether GRIN gene variation in the offspring interacted with maternal herpes simplex virus-2 (HSV-2) seropositivity during pregnancy influencing the risk of schizophrenia later in life.
|
21919190 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that glutamatergic neurotransmission via NR2A-containing NMDA receptors on PV neurons in the PFC may be deficient in schizophrenia.
|
19917116 |
2009 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The glutamatergic hypothesis of schizophrenia lead recently to a first successful mGlu2/3 receptor agonistic drug and is underpinned by significant findings in genes regulating the glutamatergic system (SLC1A6, SLC1A2 GRIN1, GRIN2A, GRIA1, NRG1, ErbB4, DTNBP1, DAAO, G72/30, GRM3).
|
17982252 |
2007 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
These results suggest a probable genetic effect for the GRIN2A promoter (GT)n variation on the predisposition to schizophrenia in Japanese cohorts.
|
15774266 |
2005 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
GluN2A subunit containing N-methyl-d-aspartate receptors (NMDARs) are highly involved in various physiological processes in the central nervous system, but also in some diseases, such as anxiety, depression and schizophrenia.
|
28222314 |
2017 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we propose that KIF3B transports NR2A/APC complex and that its dysfunction is responsible for SCZ pathogenesis.
|
31746486 |
2020 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, the density of the GAD67+/NR2A+ neurons was decreased by 57% and 49% in layers 3 and 4, respectively, in schizophrenia, but it was unchanged in bipolar disorder.
|
18534564 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we performed western blot analysis to determine whether protein levels of NMDA receptor subunits (NR1, NR2A, NR2B) and associated PSD proteins (NF-L, PSD95, SAP102) are altered in schizophrenia.
|
16762023 |
2006 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
A significant correlation between serum d-Ser levels and GRIN2A (GT)21 in schizophrenia was detected.
|
25958346 |
2015 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we identified two de novo mutations in patients with sporadic SCZ in GRIN2A and one de novo mutation in GRIN2B in a patient with ASD.
|
22833210 |
2011 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, we found that upon crack inhalation mice have shown decreased social interaction and working memory deficits analogous to schizophrenia's symptoms, along with increased D2S/D2L expression ratio and decreased expression of NR1, NR2A and NR2B NMDA receptor subunits in the PFC.
|
28314129 |
2017 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
This evidence suggests that the NR2A (GRIN2A) gene may play a role in the development of schizophrenia and disease phenotypes.
|
12724619 |
2003 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The schizophrenia-associated gene GRIN2A (glutamate ionotropic receptor NMDA type subunit 2a) codes for a protein subunit of the NMDA (N-methyl-D-aspartate) receptor that underlies central aspects of human cognition.
|
29958946 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, compared with the normal control subjects and subjects with bipolar disorder, the density of CB+/NR2A+ neurons in layer 2 was increased by 41% to 44 % in subjects with schizophrenia, whereas the amount of NR2A mRNA/CB+ neurons was unchanged.
|
18585682 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We found decreased NR1 expression in all three illnesses, decreased NR2A in schizophrenia and major depression, and decreased NR2C in schizophrenia.We found no changes of NR2B or NR2D.
|
18033238 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In order to investigate whether early VH lesion in rats alters the expression of genes implicated in schizophrenia pre- and post-puberty, we studied the mRNA expression of neuropeptides (substance P, dynorphin and enkephalin), dopamine D1, dopamine D2, and NMDA (subunits NR1 and NR2A) receptors in this animal model.
|
19500946 |
2009 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the (GT)n polymorphism in the promoter of GRIN2A gene may play a significant role in the etiology of schizophrenia among our samples.
|
17011703 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest a probable genetic effect for the GRIN2A promoter (GT)n variation on the predisposition to schizophrenia in Japanese cohorts.
|
15774266 |
2005 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Published data suggest that GluN2A is involved in maturation and phenotypic maintenance of parvalbumin interneurons (PVIs), and these interneurons suffer from a deficient glutamatergic neurotransmission via GluN2A-containing NMDARs in schizophrenia.
|
29024713 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The present results support the hypothesis that rare de novo mutations in GRIN2A or GRIN2B can be associated with cases of sporadic SCZ or ASD, just as it has recently been described for the related neurodevelopmental disease intellectual disability.
|
22833210 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This evidence suggests that the NR2A (GRIN2A) gene may play a role in the development of schizophrenia and disease phenotypes.
|
12724619 |
2003 |