|
Abnormal behavior
|
0.110 |
Biomarker
|
phenotype |
BEFREE |
A variable (GT)(n) repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders.
|
21507155 |
2012 |
|
Abnormal behavior
|
0.110 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal involuntary eye movements
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormal myelination
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal speech prosody
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormally low-pitched voice
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Addictive Behavior
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Data obtained using Western blotting technique showed a significant increase in the level of GluN1 and GluN2B, but not in GluN2A subunits in all the three regions (mPFC, lPFC, and OFC) of men whom suffered from addiction as compared to the appropriate controls.
|
29766293 |
2019 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we propose that KIF3B transports NR2A/APC complex and that its dysfunction is responsible for SCZ pathogenesis.
|
31746486 |
2020 |
|
Agnosia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
alcohol effect
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Genetic variations in NR2A have the greatest relevance for human alcohol dependence among the glutamatergic genes selected for their known alteration of alcohol effects in animal models.
|
18606955 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
Biomarker
|
disease |
PSYGENET |
These data suggest a role for GluN2A in tolerance, extending evidence that human GluN2A gene variation is involved in alcohol dependence.
|
24397780 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
Biomarker
|
disease |
PSYGENET |
In the present study we report reduced amygdala activity during the acquisition of conditioned fear in healthy carriers of a risk variant for alcoholism (rs2072450) in the NR2A subunit-containing N-methyl-d-aspartate (NMDA)-receptor.
|
23693003 |
2013 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Genotype profiles for GLAST; N-methyl-d-aspartate-receptor subunits NR1, NR2A, and NR2B; MGLUR5; NNOS; PRKG2; CAMK4; the regulatory subunit of PI3K; and CREB were analyzed for association with alcohol dependence using multivariate statistical analysis.
|
18606955 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
Biomarker
|
disease |
BEFREE |
The aim of the current study was to determine genotype effects of four single nucleotide polymorphisms (SNPs) in the genes of the N-Methyl-d-aspartate receptor (GRIN1, GRIN2A, GRIN2C) and kainate receptor (GRIK1), which have been previously associated with alcoholism, on behavior, neural cue-reactivity and drinking outcome.
|
26289945 |
2015 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in NR2A have the greatest relevance for human alcohol dependence among the glutamatergic genes selected for their known alteration of alcohol effects in animal models.
|
18606955 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism.
|
21507155 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
Biomarker
|
disease |
PSYGENET |
Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism.
|
21507155 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
In the present study we report reduced amygdala activity during the acquisition of conditioned fear in healthy carriers of a risk variant for alcoholism (rs2072450) in the NR2A subunit-containing N-methyl-d-aspartate (NMDA)-receptor.
|
23693003 |
2013 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Significantly lower expression of NR2A and NR2B transcripts was found in susceptible regions of AD brain, whereas expression of NR2C and NR2D transcripts did not differ from that in controls.
|
15287897 |
2004 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, internalisation of synaptic NR2A-NMDAR shows greater damage to the postsynaptic Ca2+ response in comparison with the internalisation of NR2B-NMDARs; thus, the suggested neuroprotective role of the latter is very limited during synaptic transmission in AD.
|
28837653 |
2017 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
Finally, in the 5XFAD transgenic model of Alzheimer's disease (AD), RNS60 treatment upregulated expression of plasticity-related proteins PSD95 and NR2A and increased AMPA- and NMDA-dependent hippocampal calcium influx.
|
25007337 |
2014 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
CONCLUSIONS The findings of this study showed a neuroprotective effect of curcumin treatment in an in vitro model of Alzheimer's disease that was associated with the increased expression of the NMDAR subunit, NR2A.
|
29714206 |
2018 |
|
Alzheimer's Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
These results indicate that enhancing synaptic NMDARs and inhibiting extrasynaptic NMDARs concurrently showed protective effects against Aβ-induced neurotoxicity, suggesting that modulation of the balance between GluN2A and GluN2B could be a potential strategy for AD drug development and therapy.
|
28269783 |
2017 |
|
Alzheimer's Disease
|
0.060 |
AlteredExpression
|
disease |
LHGDN |
Quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) was used to determine the messenger RNA (mRNA) levels of the NMDA receptor subunits NR1, NR2A, and NR2B in the hippocampus and entorhinal cortex of postmortem brain samples from nine clinically well-characterized AD patients and nine aged controls.
|
12127670 |
2002 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Postsynaptic alteration of NR2A subunit and defective autophosphorylation of alphaCaMKII at threonine-286 contribute to abnormal plasticity and morphology of upper motor neurons in presymptomatic SOD1G93A mice, a murine model for amyotrophic lateral sclerosis.
|
20732897 |
2011 |