|
Abnormal behavior
|
0.180 |
Biomarker
|
phenotype |
BEFREE |
These findings highlight the importance of mental health of females before pregnancy and suggest that CUS before pregnancy reduces p-CREB and p-NR2B in the offspring hippocampus, which could be responsible for behavioral disorders in the adolescent offspring.
|
31419724 |
2019 |
|
Abnormal behavior
|
0.180 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Abnormal behavior
|
0.180 |
Biomarker
|
phenotype |
BEFREE |
GRIN2B encodes a subunit of NMDARs, and has been identified as a candidate gene for many psychiatric disorders, especially schizophrenia.
|
27453061 |
2016 |
|
Abnormal behavior
|
0.180 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormal behavior
|
0.180 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our results revealed a specific enhancement of GluN2B-containing NMDARs by 24HC, indicating a novel endogenous pathway to influence a subclass of NMDARs critically involved in cortical plasticity and in numerous neurological and psychiatric disorders.
|
30594698 |
2019 |
|
Abnormal behavior
|
0.180 |
Biomarker
|
phenotype |
BEFREE |
NR2B Y1472 is hypophosphorylated in NRG1+/- mutant mice, and this defect can be reversed by clozapine at a dose that reverses their behavioral abnormalities.
|
17460065 |
2007 |
|
Abnormal behavior
|
0.180 |
Biomarker
|
phenotype |
BEFREE |
In wild-type mice, systemic treatment with the NR2B antagonist, Ro25-6981 [R-(R,S)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propranol], and hippocampal small interfering RNA-mediated NR2B/Grin2b knockdown resulted in behavioral changes similar to those elicited by the Setdb1 transgene.
|
20505083 |
2010 |
|
Abnormal behavior
|
0.180 |
AlteredExpression
|
phenotype |
BEFREE |
The pathogenic relevance of NMDAR autoantibodies to behavioral abnormalities (blunted response to amphetamine-triggered activity and decreased locomotor activity and exploration) and reduced expression of synaptic proteins (the GLUN2B subtype of NMDAR and PSD-95) has been demonstrated in infected mice.
|
30037790 |
2018 |
|
Abnormal behavior
|
0.180 |
GeneticVariation
|
phenotype |
BEFREE |
Mutations in the GRIN2B gene (MRD6, MIM613970) have been identified as a common cause of ID (prevalence of 0.5 - 1% in individuals with ID) associated with EEG and behavioral problems.
|
23718928 |
2013 |
|
Abnormal behavior
|
0.180 |
AlteredExpression
|
phenotype |
BEFREE |
We also used gap-prepulse inhibition of the acoustic startle reflex (GPIAS) and noise burst prepulse inhibition of acoustic startle, and the auditory brainstem level (electrophysiological recordings of auditory brainstem responses, ABR) and NR2B expression level in the auditory cortex to evaluate whether memantine could reduce salicylate-mediated behavioral disturbances.
|
31495078 |
2019 |
|
Abnormality of skin morphology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absent speech
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Absent speech
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Acid reflux
|
0.100 |
GeneticVariation
|
phenotype |
CLINVAR |
|
|
|
|
Acute Cerebrovascular Accidents
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke.
|
29565039 |
2018 |
|
Addictive Behavior
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Data obtained using Western blotting technique showed a significant increase in the level of GluN1 and GluN2B, but not in GluN2A subunits in all the three regions (mPFC, lPFC, and OFC) of men whom suffered from addiction as compared to the appropriate controls.
|
29766293 |
2019 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Therefore, our results reveal that enhanced pSer187-SNAP25 by PKC recruits GluN2B-NMDAR to the membrane surface in the hippocampal CA1 and mediates context-induced addiction memory retrieval.
|
28884870 |
2018 |
|
Agenesis of corpus callosum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Administration of NMDA receptor subunit NR2B antagonist Ro 25-6981 into the ACC significantly alleviated the potentiation of MT stimulation-evoked LFP in the ACC of EOI rats without affecting that in control rats.
|
30786804 |
2019 |
|
Alcohol Use Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
The GRIN2B gene is involved in glutamatergic signalling and may be associated with developmental differences in AUD in brain regions such as the posterior cingulate cortex.
|
27498914 |
2017 |
|
Alcohol Use Disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
The pathway analysis provided overall negative findings, although several genes including GRIN2B showed high percentage of associated SNPs for BD-AUD.
|
26563126 |
2016 |
|
Alcohol withdrawal syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The associations of GRIN2B polymorphism (rs1806201) with alcohol withdrawal and related clinical parameters in alcohol dependent subjects were investigated.
|
26771436 |
2017 |
|
Alcohol withdrawal syndrome
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal.
|
19350219 |
2009 |
|
Alcoholic Intoxication, Chronic
|
0.380 |
Biomarker
|
disease |
PSYGENET |
These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism.
|
16911840 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
GABRB2 and GRIN2B genotypes were associated with significant regional differences in the pattern of beta subunit expression, but this was not influenced by alcoholism status.
|
16766085 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.380 |
Biomarker
|
disease |
LHGDN |
These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism.
|
16911840 |
2006 |