|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The proteins BAFF, ST6GALNAC2, C1GALT1, and COSMC in peripheral blood mononuclear cells (PBMCs) and plasma levels of IgA1 and galactose-deficient IgA1 (Gd-IgA1) are potential biomarkers for IgAN nephropathy.
|
27465795 |
2016 |
|
Endometrial Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The biosynthesis of the sTn antigen has been linked to the expression of the sialytransferase ST6GalNAc1, and also to mutations in and loss of heterozygosity of the COSMC gene. sTn neo- or over-expression occurs in many types of epithelial cancer including gastric, colon, breast, lung, oesophageal, prostate and endometrial cancer. sTn is believed to be carried by a variety of glycoproteins and may influence protein function and be involved in tumour development.
|
26927062 |
2016 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Aberrant Cosmc genes result in Tn antigen expression in human colorectal carcinoma cell line HT-29.
|
26045765 |
2015 |
|
Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The Tn antigen, which arises from mutation in the Cosmc gene is one of the most common tumor associated carbohydrate antigens.
|
26045765 |
2015 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.
|
26021314 |
2015 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer.
|
26021314 |
2015 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Since the role of Tn antigen expression in PDAC is insufficiently understood we analyzed the impact of COSMC mediated Tn antigen expression in two human PDAC cell lines on cellular oncogenic properties.
|
26021314 |
2015 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
(3) We replicated a previous association of FOXP3, a transcription factor that regulates T-cell development and function, with vitiligo; and (4) we discovered that C1GALT1C1 exhibits sex-specific effect on disease risk in both IBDs.
|
25479423 |
2014 |
|
Vitiligo
|
0.010 |
Biomarker
|
disease |
BEFREE |
(3) We replicated a previous association of FOXP3, a transcription factor that regulates T-cell development and function, with vitiligo; and (4) we discovered that C1GALT1C1 exhibits sex-specific effect on disease risk in both IBDs.
|
25479423 |
2014 |
|
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding)
|
0.010 |
Biomarker
|
disease |
BEFREE |
(3) We replicated a previous association of FOXP3, a transcription factor that regulates T-cell development and function, with vitiligo; and (4) we discovered that C1GALT1C1 exhibits sex-specific effect on disease risk in both IBDs.
|
25479423 |
2014 |
|
Hemangioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, immunohistochemistry showed that COSMC was upregulated in proliferating hemangiomas compared with involuted hemangiomas.
|
23424651 |
2013 |
|
Strawberry nevus of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, roles of COSMC in infantile hemangioma are still unclear.
|
23424651 |
2013 |
|
Infantile hemangioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, roles of COSMC in infantile hemangioma are still unclear.
|
23424651 |
2013 |
|
Autoimmune Diseases
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Although decreased C1GALT1 activity has been implicated in the IgAN pathogenesis and cosmc chaperone mutations can cause autoimmune disease, our data provide no evidence for a relevant role of cosmc gene mutations in European patients with sporadic or familial IgAN.
|
18840896 |
2009 |