Post-Traumatic Stress Disorder
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Several GR pathway components predicted subsequent development of a high level of PTSD symptoms: predeployment high GR number, low FKBP5 mRNA expression, and high GILZ mRNA expression were independently associated with increased risk for a high level of PTSD symptoms.
|
22137507 |
2012 |
Post-Traumatic Stress Disorder
|
0.300 |
Biomarker
|
disease |
BEFREE |
Characterizing changes in glucocorticoid receptor internalization in the fear circuit in an animal model of post traumatic stress disorder.
|
30532228 |
2018 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Relationship of a common polymorphism of the glucocorticoid receptor gene to traumatic memories and posttraumatic stress disorder in patients after intensive care therapy.
|
21169818 |
2011 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, single nucleotide polymorphisms in the GR and FKBP5 genes have been found to be associated with increased risk for PTSD.
|
22981834 |
2013 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether childhood maltreatment and its severity were associated with increased methylation of the exon 1(F) NR3C1 promoter, in 101 borderline personality disorder (BPD) and 99 major depressive disorder (MDD) subjects with, respectively, a high and low rate of childhood maltreatment, and 15 MDD subjects with comorbid post-traumatic stress disorder (PTSD).
|
22832351 |
2011 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The DST and GR polymorphisms were also performed in 42 combat exposed Vietnam war veterans without PTSD.
|
15511603 |
2005 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Specific patterns of a dysregulation of the HPA axis and GR function are found in different stress-related psychiatric entities e.g. major depression, job-related exhaustion or posttraumatic stress disorder.
|
29449045 |
2018 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
PTSD was associated with NR3C1 epigenetic modifications that were similarly found in the mothers and their offspring, modifications that may underlie the possible transmission of biological alterations of the HPA axis.
|
24690014 |
2014 |
Post-Traumatic Stress Disorder
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Reduced peripheral expression of the glucocorticoid receptor α isoform in individuals with posttraumatic stress disorder: a cumulative effect of trauma burden.
|
24466032 |
2014 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The protective effects of dexamethasone on postoperative PTSD symptoms were dependent on the GR polymorphisms rs41423247 (p = .009), rs10052957 (p = .003), and rs6189 (p = .002), but not on rs6195 (p = .025) or rs6198, (p = .026) after Bonferroni correction.
|
29879676 |
2018 |
Post-Traumatic Stress Disorder
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Results show that genes related to the physiological stress response (e.g., glucocorticoid receptor and activity, neuroendocrine release), learning and memory (e.g., plasticity), mood, and pain perception are tied to neural intermediate phenotypes associated with PTSD.
|
27109180 |
2016 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Nonetheless, aberrant hypothalamus-pituitary-adrenal (HPA) axis activity, especially in terms of cortisol and glucocorticoid receptor (GR) alterations, has been postulated as a tenable factor in the etiology and pathophysiology of PTSD.
|
31191267 |
2019 |
Post-Traumatic Stress Disorder
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity.
|
31322414 |
2019 |
Post-Traumatic Stress Disorder
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
STAT5B, a direct inhibitor of GR, and nuclear factor I/A, both showed reduced expression in PTSD.
|
21508514 |
2011 |
Post-Traumatic Stress Disorder
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
FKBP5, a modulator of glucocorticoid receptor (GR) sensitivity, showed reduced expression in PTSD, consistent with enhanced GR responsiveness.
|
19393990 |
2009 |
Post-Traumatic Stress Disorder
|
0.300 |
Biomarker
|
disease |
BEFREE |
Finally, NR3C1-1F promoter methylation was inversely correlated with clinical markers and symptoms associated with PTSD.
|
24661442 |
2015 |
Post-Traumatic Stress Disorder
|
0.300 |
Biomarker
|
disease |
BEFREE |
This genetic interaction was also paralleled by FKBP5 genotype-dependent and PTSD-dependent effects on glucocorticoid receptor sensitivity, measured by the dexamethasone suppression test.
|
18349090 |
2008 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The FKBP5 polymorphism modulates glucocorticoid receptor sensitivity, and has been shown to increase risk for PTSD.
|
26456144 |
2015 |
Post-Traumatic Stress Disorder
|
0.300 |
Biomarker
|
disease |
BEFREE |
Evidence that the GR may be an important therapeutic target for the treatment of PTSD, especially for functions subserved by the hippocampus, is discussed.
|
29734228 |
2019 |
Post-Traumatic Stress Disorder
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, NR3C1 baseline methylation significantly interacted with child abuse to predict PTSD symptom change following GSK561679 treatment.
|
30390684 |
2018 |
Post-Traumatic Stress Disorder
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Posttraumatic stress disorder (PTSD) is characterized by a reduced expression of FKBP5, a key modulator of the glucocorticoid receptor.
|
23856297 |
2013 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The GR gene SNP BclI has been associated with hypersensitivity to glucocorticoids and PTSD symptoms.
|
26872620 |
2016 |
Post-Traumatic Stress Disorder
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
In light of its role in glucocorticoid receptor transactivation, we investigated whether SKA2 DNA methylation influences cortisol stress reactivity and is involved in the development of post-traumatic stress disorder (PTSD).
|
26361058 |
2016 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In our endocrine study, we found that only risk allele A carriers of rs9296158 showed GR supersensitivity with PTSD; in contrast, baseline cortisol levels were decreased in PTSD only in patients with the GG genotype.
|
21536970 |
2011 |
Post-Traumatic Stress Disorder
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In a recent study in patients who underwent cardiac surgery, the BclI polymorphism of the glucocorticoid receptor gene (NR3C1) was associated with traumatic memories and posttraumatic stress disorder symptoms after intensive care therapy.
|
23148886 |
2013 |