|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
High GROβ cytoplasm staining was significantly associated with patients' age (P = 0.043) and tumor location (P = 0.014), while high GROβ nucleus staining was significantly associated with mitotic index (P = 0.034), tumor location (P = 0.049), and AFIP-Miettinen risk classification (P = 0.048).
|
25944970 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The underlying mechanism for this transformation by ttIL-12 treatment was induction of expression of CXCL9 and reduction of expression of CXCL2 and CCL22 in tumors.
|
31208461 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we showed that MDSC recruitment to the primary tumor and metastatic sites occurs via direct ΔNp63-dependent activation of the chemokines CXCL2 and CCL22.
|
30295647 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, tumors with higher CXCL2 expression included significantly more numbers of multiple tumors than the lower expression group.
|
30564899 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Snail knockdown reduces the expression of CXCR2 ligands (CXCL1 and CXCL2), chemokines that attract MDSCs to the tumor via CXCR2.
|
29703902 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the validation cohort, however, only the changes in the plasma levels of CXCL2 and MMP2 after treatment were associated with PFS (p = 0.003 and p = 0.006, respectively), and these changes were maintained during the course of anti-PD-1 therapy in patients who showed better clinical outcomes, even in those with tumor pseudoprogression.
|
30307035 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MTX stimulated the production of CXCL8 by human cancer cells in vitro and that of Cxcl2 by murine tumors in vivo.
|
23787997 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using a genetically engineered mouse model of PDA, we found that tumor and stromal cells differentially expressed CXCR2 ligands, with Cxcl5 high in tumor and Cxcl2 high in stroma.
|
27737879 |
2016 |
|
Pneumonitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
TNF-α, MIP-2α, and injury score at 6 h IRB returned to control. p38 activation contributes to IRB-induced pulmonary inflammation.
|
29974374 |
2018 |
|
Pneumonitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
We then treated mice with PvdQ during lethal <i>P. aeruginosa</i> pulmonary infection and that resulted in a 5-fold reduction of lung bacterial load and a prolonged survival of the infected animals with the median survival time of 57 hin comparison to 42 h for the PBS-treated group.In a sublethal <i>P. aeruginosa</i> pulmonary infection, PvdQ treatment resulted in less lung inflammation as well as decrease of CXCL2 and TNF-α levels at 24 h post-bacterial-infection by 15 and 20%, respectively.
|
29755959 |
2018 |
|
Pneumonitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
Thus, our data indicate that PLAG may represent a potential therapeutic agent for resolution of LPS-induced lung inflammation through effective MIP-2 modulation.
|
31620122 |
2019 |
|
Pneumonitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury.
|
28935640 |
2018 |
|
Pneumonitis
|
0.070 |
Biomarker
|
disease |
BEFREE |
Given the bioactivities of MIP-1 alpha and beta and MIP-2 and the recent studies demonstrating their association with lung inflammation, it is likely these chemokines play a significant role in respiratory tract defenses and may contribute to the pathogenesis of inflammatory lung disease.
|
7882902 |
1995 |
|
Pneumonitis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
We additionally show that chronic CS exposure in mice promoted AMPK phosphorylation and expression of MIP-2α (an IL-8 homolog) in LECs and lungs, as well as lung inflammation, all of which were reduced by Compound C treatment.
|
21376115 |
2011 |
|
Pneumonitis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
The liver and lung inflammations in mice with ClC-3 deletion were significantly less than those in wild-type mice, and the levels of TNF-α and MIP-2 in serum were lower than those of wild-type mice.
|
29972266 |
2018 |
|
Hepatitis
|
0.040 |
Biomarker
|
group |
BEFREE |
Further understanding of the regulatory mechanisms of MIP-2 secretion and activation may be helpful to develop MIP-2-targeted therapeutic strategies to prevent liver inflammation.
|
28533661 |
2017 |
|
Hepatitis
|
0.040 |
Biomarker
|
group |
BEFREE |
In the present study, we examined the mechanisms underlying CXCL2 regulation by SHP and the cell types involved in liver inflammation.
|
30323351 |
2018 |
|
Hepatitis
|
0.040 |
AlteredExpression
|
group |
BEFREE |
We found that also in the WT situation, Shp expression gradually decreased, while Cxcl2 expression increased until 6 h, and vice versa at 24 h upon ConA-treatment, indicating an inverse correlation between Shp and Cxcl2 expression during ConA-induced hepatitis.
|
29409050 |
2018 |
|
Hepatitis
|
0.040 |
Biomarker
|
group |
BEFREE |
The E. chaffeensis strain Wakulla induces diffuse hepatitis with neutrophil infiltration in mice with severe combined immunodeficiency, which is accompanied by strong CXCL2 (mouse functional homolog of interleukin-8 [IL-8]) and tumor necrosis factor alpha (TNF-α) expression in the liver.
|
21930764 |
2011 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Overall, high GRO-β expression correlates with poor prognosis and contributes to ovarian cancer tumorigenesis and metastasis.
|
26063953 |
2015 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Here, we give a brief introduction to the basic molecular and cellular sources of MIP-2, and focus on its physiological and pathological functions in acute liver injury induced by concanavalin A, lipopolysaccharides, irradiation, ischemia/reperfusion, alcohol, and hypoxia, and hepatectomy-induced liver regeneration and tumor colorectal metastasis.
|
28533661 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Triptonide potently suppresses pancreatic cancer cell-mediated VM by reducing tumor cell migration and invasion and inhibiting expression of VE-cadherin and CXCL2 genes.
|
29162433 |
2018 |
|
Obesity
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We found that early arthritis triggered by obesity is due to elevated joint MIP2/interleukin-8 levels detected in CIA as well as in the RA and mouse adipose tissues and the effect of this chemokine on neutrophil recruitment.
|
27797749 |
2017 |
|
Obesity
|
0.040 |
Biomarker
|
disease |
BEFREE |
B cells from obese/insulin-resistant hosts also support oral osteoclastogenesis and both oral and systemic production of inflammatory cytokines, including pro-osteoclastogenic TNF-α and MIP-2, an ortholog of human IL-8.
|
24782490 |
2014 |
|
Obesity
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |