Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
p53 gene mutations, and CYP1A1 and GSTM1 genotypes in pulmonary squamous cell carcinomas.
|
9231161 |
1997 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
p53, but not p16 mutations in oral squamous cell carcinomas are associated with specific CYP1A1 and GSTM1 polymorphic genotypes and patient tobacco use.
|
9525287 |
1998 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of CYP1A1 and GSTM1 genes and susceptibility to oral cancer.
|
17461521 |
2007 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the CYP1A1 and GSTM1 gene involved in oral squamous cell carcinoma in association with a cigarette dose.
|
10435155 |
1999 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis showed a significant relationship between squamous carcinoma (SC), adenocarcinoma (AC) or small cell lung carcinoma (SCLC) and GSTM1 null genotype, as well as SC or AC and GSTT1 null genotype.
|
25036724 |
2014 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 null genotype was associated with a decreased risk of squamous cell carcinoma: the OR, adjusted for age, sex and pack years was 0.32 (95% CI 0.12-0.82).
|
12175548 |
2002 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combined 'at risk' genotypes of GSTM1 null and GSTT1 null in comparison with 'wild-type' genotypes seems to be associated with a greater risk of lung cancer, but the results are not significant (odds ratio (OR) 2.0, 95% confidence interval (CI) 0.68-5.96) and for squamous cell carcinoma (SqCC) it was 1.6-fold (OR 1.6, 95% CI 0.49-5.68).
|
18415801 |
2008 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of one null genotype of the GSTM1 or GSTT1 gene was higher in patients with pharyngeal SCC and heavy smoking status than in controls (76.3% versus 57.7%, P = 0.04).
|
21870186 |
2011 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the null GSTM1 gene was 42.3% among the lung cancer patients with no preferential tendency towards developing squamous cell carcinoma versus adenocarcinoma (OR = 1.10, 95% CL = 0.3-4.14, P = 0.5).
|
9029171 |
1997 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genotype for GSTM1 (mutation vs. wild type) was determined by polymerase chain reaction (PCR) using genomic DNA extracted from peripheral blood from 28 OSCC patients.
|
20060357 |
2010 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The presence of at least one copy of the CYP1A1 MspI variant allele was found to be associated with a 2.4-fold (95% CI, 1.2-4.7) increase in the risk of SCC when this gene was considered singly and a 3.1-fold (95% CI, 1.2-7.9) increase in the risk of SCC when combined with a GSTM1 deletion.
|
9809991 |
1998 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC).
|
15668931 |
2005 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The role of CYP1A1 inducibility was found to be more important than that of GSTM1 polymorphism, because the non-inducible CYP1A1 was associated solely with bronchial tumours (P = 0.001), mainly squamous cell carcinomas.
|
8020145 |
1994 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results are supported by logistic regressions of patients allowing interactions between tumour type (or treatment) and PY (or age), and indicate that the GSTM1-null genotype could be an important susceptibility factor for SQ while the NAT2-slow genotype may have an impact on other types of lung cancer.
|
10607733 |
2000 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have studied genetic variation at the glutathione S-transferase GSTM1 locus to see whether phenotypes confer altered susceptibility to basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), or multiple skin tumours of different histological types.
|
7905099 |
1994 |
Squamous cell carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We identified individuals at high risk genetically for oral SCC in terms of polymorphisms of the CYP1A1 and GSTM1 genes.
|
10506106 |
1999 |
Squamous cell carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms.
|
9139841 |
1997 |
Squamous cell carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While adjusted odds ratios (ORs) indicated no significantly increased risk for lung cancer overall due to any single GST genotype, the risk alleles for GSTM1, GSTM3 and GSTP1 conferring reduced enzyme activity were present at higher frequency in SCC than in AC patients.
|
11740339 |
2001 |