|
Acromegaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we assessed the contribution of GSTP1 gene promoter methylation status, per se or in combination with the occurrence of the AHR gene rs2066853 variant, on clinical features and response to somatostatin analogs (SSA) treatment in acromegaly patients.
|
30488289 |
2019 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported.
|
31357662 |
2019 |
|
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We investigated the immunohistochemical staining characteristics of cytochrome P450 1A1 (CYP1A1), CYPB1, CYP2E1, and glutathione S-transferase P1 (GSTP1), GSTT1, GSTO1, GSTK1 in colon tumor and surrounding normal colon tissues.
|
30092668 |
2019 |
|
Colonic Polyps
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GSTP1-methyl patients showed a higher prevalence of diabetes mellitus (p = 0.01), colonic polyps (p = 0.05), and were more resistant to SSA (p = 0.02) as compared to GSTP1 unmethylated patients (GSTP1-unmethyl).
|
30488289 |
2019 |
|
Deglutition Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In addition, the presence of G allele of GSTP1 was associated with a significantly lower risk of severe dysphagia (P = .0004).
|
30973677 |
2019 |
|
Nausea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
GSTP1 c.313A>G genotyping may reduce the use of preventive support for chemotherapy induced nausea and lower the overall cost of treatment.
|
30870506 |
2019 |
|
Malignant neoplasm of testis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CYP1A1*2C, GSTM1null, GSTT1null, and GSTP1 (rs1695) are statistically related to the risk of appearance of TCa, alone or associated with nongenetic factors.
|
31107374 |
2019 |
|
Asymmetric Septal Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).
|
30951700 |
2019 |
|
Abnormal behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported.
|
31357662 |
2019 |
|
Neurodegenerative Disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
The involvement of GSTP in the oxidative stress and in other human pathologies like cancer, liver and neurodegenerative diseases, and psychiatric disorders is also reported.
|
31357662 |
2019 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Methods</b>: A meta-analysis about <i>GSTP1</i>, <i>GSTM1</i> and <i>GSTT1</i> variants and the GSTP1 expression level on chemotherapy efficacy of GIC patients was performed using data from PubMed, PMC, EMBASE, Web of Science, and Wanfang database.
|
31281468 |
2019 |
|
Malignant Testicular Germ Cell Tumor
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
CYP1A1*2C, GSTM1null, GSTT1null, and GSTP1 (rs1695) are statistically related to the risk of appearance of TCa, alone or associated with nongenetic factors.
|
31107374 |
2019 |
|
Venoocclusive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
GSTA1, GSTM1 and GSTP1 were not significantly associated with VOD occurrence.
|
30511436 |
2019 |
|
Drug Dependence
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Relationship between glutathione S-transferase P1 (GSTP1, OMIM: 134660) variants and the risk of drug dependency is unknown.
|
30121884 |
2019 |
|
Neoplasms, Intracranial
|
0.010 |
AlteredExpression
|
group |
BEFREE |
GSTP1 and CYP expression is increased in intracranial tumors.
|
30321868 |
2019 |
|
Malignant transformation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results revealed a novel potential mechanism of HDV-induced liver injury and hepatocarcinogenesis: s-HDAg can inhibit GSTP1 expression by directly binding to GSTP1 mRNA, which leads to accumulation of cellular ROS, resulting in high cellular apoptotic ratios and increased selective pressure for malignant transformation.
|
30153423 |
2019 |
|
Alcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).
|
30951700 |
2019 |
|
Sessile Serrated Adenoma/Polyp
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we assessed the contribution of GSTP1 gene promoter methylation status, per se or in combination with the occurrence of the AHR gene rs2066853 variant, on clinical features and response to somatostatin analogs (SSA) treatment in acromegaly patients.
|
30488289 |
2019 |
|
Advanced Head and Neck Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of GSTP1 and ERCC1 polymorphisms with toxicity in locally advanced head and neck cancer platinum-based chemoradiotherapy treatment.
|
30973677 |
2019 |
|
Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
The different expression of tumor suppressors, RASSF1A, RUNX3, and GSTP1, in patients with alcoholic steatohepatitis (ASH) vs non-alcoholic steatohepatitis (NASH).
|
30951700 |
2019 |
|
Agranulocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
GSTP1 rs1695 gene polymorphism showed a significant correlation with granulocytopenia induced by platinum-based drugs (dominant genetic model: OR=1.60, 95% CI=1.19.
|
30238837 |
2018 |
|
Dry Eye Syndromes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of differential protein expression between study groups: We observed increased expression of proteins S100A4, S100A8, retinal dehydrogenase-1, peroxiredoxin-1, annexin-A1, annexin-A2, α-enolase, and glutathione S-transferase-P in DE, whereas the highest expression of peroxiredoxin-6, actin cytoplasmic-1, peroxiredoxin-2, and heat shock protein HSP-90-α was observed in MGD; ii).
|
28336260 |
2018 |
|
Gastritis, Atrophic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two pairwise combinations (<i>ERCC5</i> rs2094258 and rs873601 with <i>GSTP1</i> rs1695) influenced AG risk (<i>P</i><sub>interaction</sub> = 0.008 and 0.043, respectively), and the ERCC5 rs2094258-GSTP1 rs1695 SNP pair demonstrated an antagonistic effect, while <i>ERCC5</i> rs873601-<i>GSTP1</i> rs1695 showed a synergistic effect on AG risk OR = 0.51 and 1.79, respectively).
|
29434449 |
2018 |
|
Neurofibromatosis 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
On the other hand, SWCNT exposure showed hypermethylation on functionally important genes, such as SKI proto-oncogene (SKI), glutathione S-transferase pi 1 (GTSP1) and shroom family member 2 (SHROOM2) and neurofibromatosis type I (NF1), which the latter is both hypermethylated and downregulated.
|
29426343 |
2018 |
|
Rhinitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associated with rhinitis and/or asthma in adults of Portuguese ancestry.
|
27561723 |
2018 |