Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, levels of transcript were significantly elevated (up to 16-fold) in total RNA derived from bladder and ureteric carcinomas, with the highest levels of elevation approaching those previously found only for the GST-P gene in experimentally induced rodent hepatocellular carcinomas.
|
3359415 |
1988 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Highly metastatic hepatocellular carcinomas induced in male F344 rats treated with N-nitrosomorpholine in combination with other hepatocarcinogens show a high incidence of p53 gene mutations along with altered mRNA expression of tumor-related genes.
|
9029167 |
1997 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Using a PCR assay, somatic GSTP1 <CpG island> DNA hypermethylation was also detected in HCC DNA from 17 of 20 HCC cases.
|
10717233 |
2000 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
These data indicate that epigenetic silencing of GSTP1 gene expression by CpG island DNA hypermethylation is common in human HBV-associated HCC.
|
11948118 |
2002 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
During the pathogenesis of human hepatocellular carcinoma (HCC), the CpG island encompassing the pi-class glutathione S-transferase gene (GSTP1) becomes hypermethylated.
|
11960994 |
2002 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
We report here that inhibition of transcription from hypermethylated GSTP1 promoters in Hep3B HCC cells, which fail to express GSTP1 mRNA or GSTP1 polypeptides, appears to be mediated by MBD2.
|
11960994 |
2002 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genes frequently methylated in HCC were APC (81.7%), GSTP1 (76.7%), RASSF1A (66.7%), p16 (48.3%), COX-2 (35%), and E-cadherin (33.3%).
|
14507645 |
2003 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Immunohistochemical expression of pi class glutathione S-transferase and alpha-fetoprotein in hepatocellular carcinoma and chronic liver disease.
|
14714299 |
2003 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most frequently methylated TSGs in HCC were: SOCS-1 (65%), GSTP (54%), APC (53%), E-cadherin (49%), and p15 (49%).
|
12937151 |
2003 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
No association between GSTP1 gene aberrant promoter methylation and prognosis in surgically resected hepatocellular carcinoma patients from the Basque Country (Northern Spain).
|
12895264 |
2003 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GSTP1 expression by immunohistochemical staining of HCC tissue samples was significantly associated with methylation status.
|
15808399 |
2005 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
GSTP1 inactivation via CpG island hypermethylation in hepatocellular carcinoma (HCC) was previously reported, but the involvement of NQO1 in HCC is not well known.
|
15763338 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hypermethylated status of the promoter regions of p16INK4a, RASSF1A, E cadherin, and GSTP1 was observed in 10 (40%), 14 (56%), 6 (24%), and 12 (48%) of 25 patients with hepatocellular carcinoma, respectively.
|
16613325 |
2006 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data indicate that the epigenetic aberrance of promoter CpG island hypermethylation of the GSTP1 gene may contribute to the hepatopathogenesis of HCC and is a potential valuable biomarker for noninvasive disease monitoring and HCC early diagnosis.
|
16527261 |
2006 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
We conclude that the studied polymorphisms affecting GSTP1, GSTA1 and GSTM3 genes are probably not related to the risk of developing hepatocellular carcinoma in the studied population.
|
17716224 |
2007 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
The frequency of GSTP1 promoter hypermethylation is significantly higher in HCC than in nontumorous tissues (p = 0.022) from HBsAg-positive patients, but not the HBsAg-negative controls (p = 0.289).
|
17534893 |
2007 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A real-time PCR assay with glutathione S-transferase pi (GSTP1) gene was used to measure cell-free DNA levels in the sera of 52 patients with hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV), which included 30 HCV carriers without known HCC and 16 HCV-negative non-cancer patients (controls).
|
17214331 |
2007 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the studied polymorphisms affecting GSTP1, GSTA1 and GSTM3 genes are probably not related to the risk of developing hepatocellular carcinoma in the studied population.
|
17716224 |
2007 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
GSTP1 and/or p16(INK4a) promoter methylation was observed in 88% of the HCC samples.
|
18351580 |
2008 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, hypermethylation of some specific, but not all, tumor associated genes may be involved in hepatocarcinogenesis; examination of the methylation status of E-cadherin, GSTP1, P16, and RASSF1A in the plasma samples might have limited usage for HCC diagnosis.
|
18691570 |
2008 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The methylation frequencies of the ten genes examined in HCC were 40.0% for p14 ( ARF ), 60.9% for p15 ( INK4b ), 70.4% for p16 ( INK4a ), 34.8% for p73, 70.4% for GSTP1, 64.3% for MGMT, 13.0% for hMLH1, 59.1% for RARbeta, 82.6% for SOCS-1, and 80.9% for OPCML.
|
20112070 |
2010 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AG and GG alleles of GSTP1 gene polymorphisms may be considered as factors increasing the susceptibility to and risk of HCC in Taiwanese aged < or = 57 years.
|
20331903 |
2010 |
Liver carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Importantly, our analysis revealed an association between alcohol intake and the hypomethylation of MGMT and between hypermethylation of GSTP1 and HBV infection, indicating that hypermethylation of the genes analyzed in HCC tumors exhibits remarkably distinct patterns depending on associated risk factors.
|
21146512 |
2011 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Encouragingly, 33.8% of the AFP-negative HCC contained the methylated GSTP1 gene.
|
22536438 |
2012 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals carrying null GSTM1 and GSTP1 Val/Val who received chemotherapy had lower risk of death from HCC than those without chemotherapy.
|
22994742 |
2012 |