Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For further support from within the Han Chinese ethnic group, we selected two single nucleotide polymorphisms (SNP) located at the distal 5'-end (rs1633445; intron 10 of HpaII tiny fragments locus 9C, HTF9C) and the intron 4 (rs175174) of ZDHHC8 gene to test if these were associated with schizophrenia in a study sample of Taiwan.
|
18075473 |
2007 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The findings on rs175174 at ZDHHC8 are still far from being conclusive, but evidence for sexual dimorphism is moderate, and our data do not support a significant genetic contribution of rs175174 to the aetiopathogenesis of schizophrenia.
|
16225675 |
2005 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.
|
15992527 |
2005 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of the ZDHHC8 gene locus with schizophrenia using meta-analytic techniques, combining all published data up to May 2009 and focusing on 10 independent studies from six published references covering 2,894 cases, 2,932 controls and 1,225 parent-offspring trios.
|
20661937 |
2010 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We selected four putative risk variants, residing within these genes, ProDH 1945, ProDH 2026, COMT ValMet and ZDHHC8 rs175174, and studied these in a large family-based schizophrenia association sample of European origin (488 Bulgarian parent-offspring trios).
|
16860541 |
2006 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because our sample size provided quite high power, ZDHHC8 may not play a major role in Japanese schizophrenia.
|
15631889 |
2005 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Systematic examination of individual genes from the 1.5 Mb critical region has identified so far the PRODH and ZDHHC8 as strong candidate schizophrenia susceptibility genes from this locus.
|
15582150 |
2004 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia.
|
23403413 |
2013 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results provided compelling supportive evidence for association of the variants within the ZDHHC8 locus with schizophrenia but revealed different risk allele at SNP rs175174.
|
15489219 |
2004 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.
|
16150541 |
2005 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study reveals a new role of ZDHHC8-cdc42-palm molecular pathway in postsynaptic structural plasticity and provides new evidence in favor of the dysconnectivity hypothesis for schizophrenia.
|
27365300 |
2017 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia.
|
20468065 |
2010 |
Bipolar Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia.
|
16150541 |
2005 |
Borderline Personality Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.
|
16150541 |
2005 |
Bronchopulmonary Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that the ZDHHC8 gene may not be associated with susceptibility to BPD or schizophrenia, at least in a Japanese population.
|
16150541 |
2005 |
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
We first found increased ZDHHC8 expression in the brains of temporal lobe epilepsy (TLE) patients, similar to that observed in chronic epileptic mice, strongly suggesting that ZDHHC8 is correlated with human epilepsy.
|
30038264 |
2018 |
Epilepsy, Temporal Lobe
|
0.010 |
Biomarker
|
disease |
BEFREE |
We first found increased ZDHHC8 expression in the brains of temporal lobe epilepsy (TLE) patients, similar to that observed in chronic epileptic mice, strongly suggesting that ZDHHC8 is correlated with human epilepsy.
|
30038264 |
2018 |
Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
SiRNA-induced ZDHHC8 knockdown in 211H and H2052 mesothelioma cells significantly reduced cell survival after X-irradiation.
|
22017350 |
2012 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
In 211H tumor-bearing mice, ZDHHC8 siRNA and X-irradiation significantly suppressed tumor growth, whereas ZDHHC8 siRNA alone did not.
|
22017350 |
2012 |
Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
ZDHHC8 levels were consistent with seizure susceptibility in induced mice with SRSs.
|
30038264 |
2018 |
Malignant mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, the combination of ZDHHC8 siRNA and X-irradiation has the potential to improve the therapeutic efficacy of radiation therapy for malignant mesothelioma.
|
22017350 |
2012 |
22q11 Deletion Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The zinc finger DHHC domain-containing protein 8 (ZDHHC8) is located in the 22q11 microdeletion region and may contribute to the behavioral deficit associated with 22q11 deletion syndrome.
|
20468065 |
2010 |
Total anomalous pulmonary venous return
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We identified 42 rare variants of 7 genes (CLTCL1, CST3, GXYLT1, HMGA2, SNAI1, VAV2, ZDHHC8) in TAPVC cases compared with controls.
|
30448225 |
2018 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
We investigated the association of the ZDHHC8 gene locus with schizophrenia using meta-analytic techniques, combining all published data up to May 2009 and focusing on 10 independent studies from six published references covering 2,894 cases, 2,932 controls and 1,225 parent-offspring trios.
|
20661937 |
2010 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia.
|
20468065 |
2010 |